Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T64795 | Target Info | |||
| Target Name | Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) | ||||
| Synonyms | Voltage-gated calcium channel alpha subunit Cav3.1; Voltage-dependent T-type calcium channel; NBR13; Cav3.1c; CACNA1G | ||||
| Target Type | Successful Target | ||||
| Gene Name | CACNA1G | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol hemisuccinate | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C | ||||
| InChI | 1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1 | ||||
| InChIKey | WLNARFZDISHUGS-MIXBDBMTSA-N | ||||
| PubChem Compound ID | 65082 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6KZO membrane protein | ||||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
NPWFERISML
89 VILLNCVTLG99 MFRPCEDIAC109 DSQRCRILQA119 FDDFIFAFFA129 VEMVVKMVAG 149 DTWNRLDFFI159 VIAGMLEYSS177 AVRTVRVLRP187 LRAINRVPSM197 RILVTLLLDT 207 LPMLGNVLLL217 CFFVFFIFGI227 VGVQLWAGLL237 RNRCFLPENF247 SLPLSVDLER 257 YYQTENEDES267 PFICSQPREN277 GMRSCRSVPT287 LRCVNWNQYY320 TNCSAGEHNP 330 FKGAINFDNI340 GYAWIAIFQV350 ITLEGWVDIM360 YFVMDAHSFY370 NFIYFILLII 380 VGSFFMINLC390 LVVIATQFSY744 FGRGIMIAIL754 VNTLSMGIEY764 HEQPEELTNA 774 LEISNIVFTS784 LFALEMLLKL794 LVYGPFGYIK804 NPYNIFDGVI814 VVISVWSVLR 834 TFRLMRVLKL844 VRFLPALQRQ854 LVVLMKTMDN864 VATFCMLLML874 FIFIFSILGM 884 HLFGCKFALP901 DRKNFDSLLW911 AIVTVFQILT921 QEDWNKVLYN931 GMASTSSWAA 941 LYFIALMTFG951 NYVLFNLLVA961 ILVEGFQAKM1254 FDHVVLVIIF1264 LNCITIAMER 1274 PKIDPHSAER1284 IFLTLSNYIF1294 TAVFLAEMTV1304 KVVALGSSWN1324 VLDGLLVLIS 1334 VIDILVSMVS1344 DSILGMLRVL1357 RLLRTLRPLR1367 VISRAQGLKL1377 VVETLMSSLK 1387 PIGNIVVICC1397 AFFIIFGILG1407 VQLFKGKFFV1417 CQGEDTRNIT1427 NKSDCAEASY 1437 RWVRHKYNFD1447 NLGQALMSLF1457 VLASKDGWVD1467 IMYDGLDAVG1477 VDQQPIMNHN 1487 PWMLLYFISF1497 LLIVAFFVLN1507 MFVGVVVENF1517 HDLFITGVIG1599 LNVVTMAMEH 1609 YQQPQILDEA1619 LKICNYIFTV1629 IFVLESVFKN1653 QLDLAIVLLS1663 IMGITLEEIE 1673 VNASLPINPT1683 IIRIMRVLRI1693 ARVLKLLKMA1703 VGMRALLDTV1713 MQALPQVGNL 1723 GLLFMLLFFI1733 FAALGVELFG1743 DLECDETHPC1753 EGLGRHATFR1763 NFGMAFLTLF 1773 RVSTGDNWNG1783 IMKDTLRDYN1800 TVISPIYFVS1810 FVLTAQFVLV1820 NVVIAVLMKH 1830 LEESNKE
|
|||||
|
|
||||||
| PDB ID: 6KZP calcium channel-ligand | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
NPWFERISML
89 VILLNCVTLG99 MFRPCEDIAC109 DSQRCRILQA119 FDDFIFAFFA129 VEMVVKMVAG 149 DTWNRLDFFI159 VIAGMLEYSL169 DLQNVSFSAV179 RTVRVLRPLR189 AINRVPSMRI 199 LVTLLLDTLP209 MLGNVLLLCF219 FVFFIFGIVG229 VQLWAGLLRN239 RCFLPENFSL 249 PLSVDLERYY259 QTENEDESPF269 ICSQPRENGM279 RSCRSVPTLR289 CVNWNQYYTN 322 CSAGEHNPFK332 GAINFDNIGY342 AWIAIFQVIT352 LEGWVDIMYF362 VMDAHSFYNF 372 IYFILLIIVG382 SFFMINLCLV392 VIATQFSETK402 QREIVDSKYF745 GRGIMIAILV 755 NTLSMGIEYH765 EQPEELTNAL775 EISNIVFTSL785 FALEMLLKLL795 VYGPFGYIKN 805 PYNIFDGVIV815 VISVWEIVSV832 LRTFRLMRVL842 KLVRFLPALQ852 RQLVVLMKTM 862 DNVATFCMLL872 MLFIFIFSIL882 GMHLFGCKFA892 SLPDRKNFDS908 LLWAIVTVFQ 918 ILTQEDWNKV928 LYNGMASTSS938 WAALYFIALM948 TFGNYVLFNL958 LVAILVEGFQ 968 FRLLCHRIIT1251 HKMFDHVVLV1261 IIFLNCITIA1271 MERPKIDPHS1281 AERIFLTLSN 1291 YIFTAVFLAE1301 MTVKVVALGS1321 SWNVLDGLLV1331 LISVIDILVS1341 MVSKILGMLR 1355 VLRLLRTLRP1365 LRVISRAQGL1375 KLVVETLMSS1385 LKPIGNIVVI1395 CCAFFIIFGI 1405 LGVQLFKGKF1415 FVCQGEDTRN1425 ITNKSDCAEA1435 SYRWVRHKYN1445 FDNLGQALMS 1455 LFVLASKDGW1465 VDIMYDGLDA1475 VGVDQQPIMN1485 HNPWMLLYFI1495 SFLLIVAFFV 1505 LNMFVGVVVE1515 NFHYLDLFIT1595 GVIGLNVVTM1605 AMEHYQQPQI1615 LDEALKICNY 1625 IFTVIFVLES1635 VFKLVAFGFR1645 RFFQDRWNQL1655 DLAIVLLSIM1665 GITLEEIEVN 1675 ASLPINPTII1685 RIMRVLRIAR1695 VLKLLKMAVG1705 MRALLDTVMQ1715 ALPQVGNLGL 1725 LFMLLFFIFA1735 ALGVELFGDL1745 ECDETHPCEG1755 LGRHATFRNF1765 GMAFLTLFRV 1775 STGDNWNGIM1785 KDTLRDYNTV1802 ISPIYFVSFV1812 LTAQFVLVNV1822 VIAVLMKHLE 1832 ESNK
|
|||||
|
|
ILE224
3.760
PHE225
3.739
VAL228
3.743
LEU232
3.943
ARG275
4.876
GLU276
3.404
ASN277
3.681
HIS367
3.399
SER368
3.118
TYR370
3.116
ASN371
3.049
ILE373
3.978
TYR374
3.862
LEU377
4.025
VAL381
4.439
LEU758
4.176
ILE762
3.089
TYR764
3.384
HIS765
4.430
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structures of apo and antagonist-bound human Ca(v)3.1. Nature. 2019 Dec;576(7787):492-497. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.