Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T67710 Target Info
Target Name Parathyroid hormone 1 receptor (PTH1R)
Synonyms Parathyroid hormone-related peptide (PTHRP); PTH1R; PTH/PTHrP type I receptor; PTH/PTHr receptor
Target Type Successful Target
Gene Name PTH1R
Biochemical Class GPCR secretin
UniProt ID
PTH1R_HUMAN
Ligand General Information  Top
Ligand Name Cholesterol Ligand Info
Canonical SMILES CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
InChI 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey HVYWMOMLDIMFJA-DPAQBDIFSA-N
PubChem Compound ID 5997
Drug Binding Sites of Target  Top
PDB ID: 6NBF      Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein
Method Electron microscopy Resolution 3.00 Å Mutation Yes [1]
PDB Sequence
VMTKEEQIFL
40
LHRAQAQCEK
50
RLKEVGRPCL
109
PEWDHILCWP
119
LGAPGEVVAV
129

PCPDYIYDFN
139
HKGHAYRRCD
149
RNGSWELVPG
159
HNRTWANYSE
169
CVKFLTNETR
179

EREVFDRLAM
189
IYTVGYSVSL
199
ASLTVAVLIL
209
AYFRRLHCTR
219
NYIHMHLFLS
229

FMLRAVSIFV
239
KDAVLYSAGY
278
AGCRVAVTFF
288
LYFLATNYYW
298
ILVEGLYLHS
308

LIFMAFFSEK
318
KYLWGFTVFG
328
WGLPAVFVAV
338
WVSVRATLAN
348
TGCWDLSSGN
358

KKWIIQVPIL
368
ASIVLNFILF
378
INIVRVLATK
388
LRETNTRQQY
403
RKLLKSTLVL
413

MPLFGVHYIV
423
FMATPYTEVS
433
GTLWQVQMHY
443
EMLFNSFQGF
453
FVAIIYCFCN
463

GEVQAEIKKS
473
WSRWTLAL
Residue
Distance (Å)
HIS225
3.502
LEU232
3.927
ALA279
3.736
ARG282
3.599
VAL283
3.689
THR286
3.734
PHE287
3.665
TYR290
4.083
PHE291
3.798
TRP322
4.046
THR325
4.017
TRP329
3.562
ALA333
4.650
PHE335
4.039
VAL340
3.671
ASN348
4.805
TRP352
4.122
ASN358
3.263
LYS359
4.365
TRP361
3.609
Residue
Distance (Å)
ILE362
3.710
VAL365
4.156
PRO366
3.909
LEU368
3.657
ALA369
3.699
VAL372
4.394
PHE375
3.992
ILE422
3.498
VAL423
4.076
ALA426
3.257
THR427
3.776
PRO428
3.408
LEU436
4.053
GLN438
3.228
VAL439
3.653
HIS442
3.758
TYR443
4.083
LEU446
3.766
PHE447
3.663
PDB ID: 6NBH      Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein
Method Electron microscopy Resolution 3.50 Å Mutation Yes [1]
PDB Sequence
VMTKEEQIFL
40
LHRAQAQCEK
50
RLKEVLGRPC
108
LPEWDHILCW
118
PLGAPGEVVA
128

VPCPDYIYDF
138
NHKGHAYRRC
148
DRNGSWELVP
158
GHNRTWANYS
168
ECVKFLTNET
178

REREVFDRLA
188
MIYTVGYSVS
198
LASLTVAVLI
208
LAYFRRLHCT
218
RNYIHMHLFL
228

SFMLRAVSIF
238
VKDAVLYSGA
248
TLTAAAGYAG
280
CRVAVTFFLY
290
FLATNYYWIL
300

VEGLYLHSLI
310
FMAFFSEKKY
320
LWGFTVFGWG
330
LPAVFVAVWV
340
SVRATLANTG
350

CWDLSSGNKK
360
WIIQVPILAS
370
IVLNFILFIN
380
IVRVLATKLR
390
ETNATRQQYR
404

KLLKSTLVLM
414
PLFGVHYIVF
424
MATPYTEVSG
434
TLWQVQMHYE
444
MLFNSFQGFF
454

VAIIYCFCNG
464
EVQAEIKKSW
474
SRWTLALDF
Residue
Distance (Å)
HIS225
3.933
LEU232
4.525
ALA279
3.685
ARG282
3.739
VAL283
3.787
THR286
3.699
PHE287
3.746
TYR290
4.097
PHE291
3.654
TRP322
3.190
THR325
4.238
VAL326
3.613
TRP329
3.755
GLY330
3.881
ALA333
4.294
PHE335
3.718
VAL340
3.784
TRP352
4.188
ASN358
3.444
LYS359
3.618
TRP361
3.578
ILE362
3.761
Residue
Distance (Å)
VAL365
4.495
PRO366
3.939
LEU368
3.785
ALA369
3.814
LEU373
4.931
PHE375
3.998
PHE378
4.584
VAL382
3.343
ARG383
3.762
ALA386
3.739
ARG390
4.528
LEU406
4.951
MET414
4.049
VAL419
3.716
ILE422
3.660
VAL423
3.956
MET425
4.872
ALA426
3.438
THR427
4.431
PRO428
3.538
LEU436
4.128
PDB ID: 6NBI      Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein
Method Electron microscopy Resolution 4.00 Å Mutation Yes [1]
PDB Sequence
MTKEEQIFLL
41
HRAQAQCEKR
51
LKRPCLPEWD
113
HILCWPLGAP
123
GEVVAVPCPD
133

YIYDFNHKGH
143
AYRRCDRNGS
153
WELTWANYSE
169
CVKFLTNETR
179
EREVFDRLAM
189

IYTVGYSVSL
199
ASLTVAVLIL
209
AYFRRLHCTR
219
NYIHMHLFLS
229
FMLRAVSIFV
239

KDAVLYSGAT
249
LTAAAGYAGC
281
RVAVTFFLYF
291
LATNYYWILV
301
EGLYLHSLIF
311

MAFFSEKKYL
321
WGFTVFGWGL
331
PAVFVAVWVS
341
VRATLANTGC
351
WDLSSGNKKW
361

IIQVPILASI
371
VLNFILFINI
381
VRVLATKLRE
391
TNAGTRQQYR
404
KLLKSTLVLM
414

PLFGVHYIVF
424
MATPYTEVSG
434
TLWQVQMHYE
444
MLFNSFQGFF
454
VAIIYCFCNG
464

EVQAEIKKSW
474
SRWTLALDF
Residue
Distance (Å)
HIS225
3.747
LEU228
4.882
LEU232
3.883
THR286
3.757
PHE287
4.589
TYR290
3.378
PHE291
3.644
THR325
4.008
TRP329
3.649
GLY330
4.389
ALA333
3.404
Residue
Distance (Å)
PHE335
4.057
VAL336
3.846
ALA337
3.818
VAL340
4.784
ASN358
3.731
LYS359
4.096
TRP361
4.669
ILE362
3.757
VAL365
4.697
PRO366
3.846
ALA369
4.684
References  Top
REF 1 Structure and dynamics of the active human parathyroid hormone receptor-1. Science. 2019 Apr 12;364(6436):148-153.

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