Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T71081 | Target Info | |||
| Target Name | GTPase HRas (HRAS) | ||||
| Synonyms | p21ras; cHras; c-H-ras; Transforming protein p21; HaRas; Ha-Ras; H-Ras-1; GTPase HRas, Nterminally processed | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | HRAS | ||||
| Biochemical Class | Small GTPase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Phosphoaminophosphonic acid-guanylate ester | Ligand Info | |||
| Canonical SMILES | C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N | ||||
| InChI | 1S/C10H17N6O13P3/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24)/t3-,5-,6-,9-/m1/s1 | ||||
| InChIKey | UQABYHGXWYXDTK-UUOKFMHZSA-N | ||||
| PubChem Compound ID | 135403657 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5X9S Crystal structure of fully modified H-Ras-GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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|
|
GLY10
4.651
ALA11
3.911
GLY12
3.340
GLY13
3.254
VAL14
3.544
GLY15
3.220
LYS16
2.646
SER17
2.678
ALA18
2.761
LEU19
4.991
PHE28
3.136
VAL29
2.641
ASP30
2.846
GLU31
3.361
TYR32
2.580
ASP33
4.168
|
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| PDB ID: 2LCF Solution structure of GppNHp-bound H-RasT35S mutant protein | ||||||
| Method | Solution NMR | Resolution | N.A. | Mutation | Yes | [2] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPSIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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|
|
GLY12
2.394
GLY13
2.393
VAL14
4.293
GLY15
3.208
LYS16
4.504
SER17
2.947
ALA18
2.528
PHE28
2.010
VAL29
3.016
TYR32
2.392
PRO34
3.320
SER35
2.706
|
|||||
| PDB ID: 2LWI Solution structure of H-RasT35S mutant protein in complex with Kobe2601 | ||||||
| Method | Solution NMR | Resolution | N.A. | Mutation | Yes | [3] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPSIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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|
|
||||||
| PDB ID: 3KKM Crystal structure of H-Ras T35S in complex with GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [4] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPSIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM111 VLVGNKCDLA 121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR161 EIRQH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.923
ALA11
3.922
GLY12
3.502
GLY13
3.142
VAL14
3.319
GLY15
3.101
LYS16
2.738
SER17
2.942
ALA18
2.834
PHE28
3.277
VAL29
2.867
ASP30
2.751
GLU31
4.110
TYR32
3.417
|
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| PDB ID: 3KKN Crystal structure of H-Ras T35S in complex with GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 2.09 Å | Mutation | Yes | [4] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPSIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
4.041
GLY12
3.343
GLY13
3.136
VAL14
3.410
GLY15
3.131
LYS16
2.631
SER17
2.914
ALA18
2.903
ASP57
4.531
THR58
4.821
ALA59
4.844
|
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| PDB ID: 7DPH H-Ras Q61H in complex with GppNHp (state 1) after structural transition by humidity control | ||||||
| Method | X-ray diffraction | Resolution | 1.54 Å | Mutation | Yes | [5] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 HQYMRTGEGF78 LCVFAINNTK88 SFEDIHQYRE98 QIKRVKDSDD108 VPMVLVGNKC 118 DLAARTVESR128 QAQDLARSYG138 IPYIETSAKT148 RQGVEDAFYT158 LVREIRQH |
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:36 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.743
ALA11
3.939
GLY12
3.478
GLY13
2.974
VAL14
3.364
GLY15
3.032
LYS16
2.675
SER17
2.989
ALA18
2.757
PHE28
3.356
VAL29
2.725
ASP30
3.141
GLU31
3.390
TYR32
2.595
ASP33
4.551
|
|||||
| PDB ID: 5B2Z H-Ras WT in complex with GppNHp (state 2*) before structural transition by humidity control | ||||||
| Method | X-ray diffraction | Resolution | 1.56 Å | Mutation | No | [6] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.623
ALA11
3.817
GLY12
3.504
GLY13
3.064
VAL14
3.255
GLY15
2.993
LYS16
2.605
SER17
2.927
ALA18
2.754
PHE28
3.223
VAL29
2.626
ASP30
2.845
GLU31
3.423
TYR32
2.562
ASP33
4.350
PRO34
3.357
|
|||||
| PDB ID: 5B30 H-Ras WT in complex with GppNHp (state 1) after structural transition by humidity control | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [6] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.694
ALA11
3.849
GLY12
3.525
GLY13
3.063
VAL14
3.321
GLY15
3.051
LYS16
2.667
SER17
2.902
ALA18
2.799
PHE28
3.386
VAL29
2.717
ASP30
3.265
GLU31
3.877
TYR32
2.829
|
|||||
| PDB ID: 4EFL Crystal structure of H-Ras WT in complex with GppNHp (state 1) | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [7] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:57 or .A:58 or .A:59 or .A:60 or .A:63 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
3.966
GLY12
3.388
GLY13
3.068
VAL14
3.330
GLY15
3.043
LYS16
2.666
SER17
2.944
ALA18
2.875
ASP57
4.544
THR58
4.993
ALA59
4.796
|
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| PDB ID: 4EFM Crystal structure of H-Ras G12V in complex with GppNHp (state 1) | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [7] |
| PDB Sequence |
MTEYKLVVVG
10 AVGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:57 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 4L9W Crystal Structure of H-Ras G12C, GMPPNP-bound | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | Yes | [8] |
| PDB Sequence |
MTEYKLVVVG
10 ACGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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GLY10
4.795
ALA11
3.965
CYS12
3.652
GLY13
3.115
VAL14
3.291
GLY15
3.041
LYS16
2.563
SER17
2.996
ALA18
2.855
PHE28
3.231
VAL29
2.656
ASP30
2.823
GLU31
3.631
TYR32
2.546
ASP33
4.383
PRO34
3.441
|
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| PDB ID: 7DPJ H-Ras Q61L in complex with GppNHp (state 1) after structural transition by humidity control | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | Yes | [5] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 LEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:36 or .A:57 or .A:58 or .A:59 or .A:60 or .A:62 or .A:63 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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GLY10
4.908
ALA11
3.925
GLY12
3.483
GLY13
2.996
VAL14
3.333
GLY15
3.058
LYS16
2.580
SER17
3.009
ALA18
2.818
PHE28
3.345
VAL29
2.678
ASP30
3.336
GLU31
3.645
TYR32
3.847
ILE36
4.966
|
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| PDB ID: 5VBZ Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | Yes | [9] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 CRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM111 VLVGNKCDLA 121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR161 EIRQH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147 or .A:148; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ALA11
3.788
GLY12
2.666
GLY13
1.911
VAL14
2.933
GLY15
2.167
LYS16
1.909
SER17
2.121
ALA18
2.045
LEU19
4.430
PHE28
2.320
VAL29
2.818
ASP30
2.946
GLU31
2.708
TYR32
2.204
ASP33
4.237
PRO34
2.838
|
|||||
| PDB ID: 4EFN Crystal structure of H-Ras Q61L in complex with GppNHp (state 1) | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [7] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 LEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:57 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6NTC Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 1 of CRAF Kinase protein | ||||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | Yes | [10] |
| PDB Sequence |
DPMTEYKLVV
8 VGAVGVGKSA18 LTIQLIQNHF28 VDEYDPTIED38 SYRKQVVIDG48 ETCLLDILDT 58 AGQEEYSAMR68 DQYMRTGEGF78 LCVFAINNTK88 SFEDIHQYRE98 QIKRVKDSDD 108 VPMVLVGNKC118 DLAARTVESR128 QAQDLARSYG138 IPYIETSAKT148 RQGVEDAFYT 158 LVREIRQH
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
3.715
VAL12
2.437
GLY13
4.331
VAL14
3.246
GLY15
3.001
LYS16
2.498
SER17
2.660
ALA18
2.760
PHE28
3.463
VAL29
3.165
ASP30
2.830
GLU31
3.445
TYR32
3.245
ASP33
4.348
PRO34
3.233
|
|||||
| PDB ID: 6NTD Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 12 of CRAF Kinase protein | ||||||
| Method | X-ray diffraction | Resolution | 3.15 Å | Mutation | Yes | [10] |
| PDB Sequence |
PMTEYKLVVV
9 GAVGVGKSAL19 TIQLIQNHFV29 DEYDPTIEDS39 YRKQVVIDGE49 TCLLDILDTA 59 GQEEYSAMRD69 QYMRTGEGFL79 CVFAINNTKS89 FEDIHQYREQ99 IKRVKDSDDV 109 PMVLVGNKCD119 LAARTVESRQ129 AQDLARSYGI139 PYIETSAKTR149 QGVEDAFYTL 159 VREIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
3.960
VAL12
2.296
GLY13
3.937
VAL14
2.961
GLY15
2.864
LYS16
2.724
SER17
2.314
ALA18
2.776
PHE28
3.781
VAL29
3.905
ASP30
3.177
GLU31
3.430
TYR32
3.257
ASP33
3.250
|
|||||
| PDB ID: 5WDQ H-Ras mutant L120A bound to GMP-PNP at 100K | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | Yes | [11] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDA120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.738
ALA11
3.810
GLY12
2.544
GLY13
1.947
VAL14
2.852
GLY15
2.218
LYS16
1.795
SER17
2.064
ALA18
1.966
LEU19
4.458
PHE28
2.817
VAL29
1.958
ASP30
2.261
GLU31
2.586
TYR32
1.690
ASP33
3.948
|
|||||
| PDB ID: 7VV9 Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [12] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.669
ALA11
3.944
GLY12
3.389
GLY13
2.993
VAL14
3.356
GLY15
3.108
LYS16
2.653
SER17
2.892
ALA18
2.787
PHE28
3.245
VAL29
2.774
ASP30
2.877
GLU31
3.637
TYR32
3.604
ASP33
4.325
PRO34
3.295
|
|||||
| PDB ID: 5WDO H-Ras bound to GMP-PNP at 277K | ||||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | No | [11] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.804
ALA11
3.933
GLY12
2.654
GLY13
2.076
VAL14
2.859
GLY15
2.231
LYS16
1.741
SER17
2.099
ALA18
1.957
LEU19
4.472
PHE28
2.821
VAL29
1.972
ASP30
2.022
GLU31
2.787
TYR32
1.683
ASP33
4.027
|
|||||
| PDB ID: 6AMB Crystal Structure of the Afadin RA1 domain in complex with HRAS | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [13] |
| PDB Sequence |
HMMTEYKLVV
8 VGAGGVGKSA18 LTIQLIQNHF28 VDEYDPTIED38 SYRKQVVIDG48 ETCLLDILDT 58 AGQEEYSAMR68 DQYMRTGEGF78 LCVFAINNTK88 SFEDIHQYRE98 QIKRVKDSDD 108 VPMVLVGNKC118 DLAARTVESR128 QAQDLARSYG138 IPYIETSAKT148 RQGVEDAFYT 158 LVREIRQHKL168
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.679
ALA11
3.650
GLY12
3.232
GLY13
3.098
VAL14
3.354
GLY15
3.076
LYS16
2.322
SER17
2.723
ALA18
2.807
PHE28
3.354
VAL29
3.186
ASP30
3.006
GLU31
4.113
TYR32
3.391
ASP33
4.052
PRO34
3.307
|
|||||
| PDB ID: 6V9M Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods | ||||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | No | [14] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.678
ALA11
3.833
GLY12
3.410
GLY13
3.081
VAL14
3.255
GLY15
3.065
LYS16
2.583
SER17
2.881
ALA18
2.755
PHE28
3.291
VAL29
2.703
ASP30
2.888
GLU31
3.476
TYR32
3.676
ASP33
4.285
PRO34
3.335
|
|||||
| PDB ID: 6V9N Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods | ||||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | No | [14] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.688
ALA11
3.833
GLY12
3.383
GLY13
3.045
VAL14
3.236
GLY15
3.054
LYS16
2.645
SER17
2.890
ALA18
2.767
PHE28
3.313
VAL29
2.690
ASP30
2.913
GLU31
3.444
TYR32
3.643
ASP33
4.276
PRO34
3.332
|
|||||
| PDB ID: 6D55 Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.68 Å | Mutation | No | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.706
ALA11
3.845
GLY12
3.381
GLY13
3.041
VAL14
3.227
GLY15
3.026
LYS16
2.594
SER17
2.960
ALA18
2.728
PHE28
3.296
VAL29
2.682
ASP30
2.763
GLU31
3.494
TYR32
3.575
ASP33
4.283
PRO34
3.288
|
|||||
| PDB ID: 6D56 Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.68 Å | Mutation | No | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.694
ALA11
3.857
GLY12
3.433
GLY13
3.026
VAL14
3.239
GLY15
3.078
LYS16
2.640
SER17
2.942
ALA18
2.769
PHE28
3.273
VAL29
2.691
ASP30
2.842
GLU31
3.440
TYR32
3.665
ASP33
4.248
PRO34
3.285
|
|||||
| PDB ID: 6D59 Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.764
ALA11
3.878
GLY12
3.391
GLY13
3.103
VAL14
3.227
GLY15
3.065
LYS16
2.642
SER17
2.992
ALA18
2.790
PHE28
3.343
VAL29
2.701
ASP30
2.869
GLU31
3.512
TYR32
3.660
ASP33
4.273
PRO34
3.352
|
|||||
| PDB ID: 6D5L Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.757
ALA11
3.849
GLY12
3.361
GLY13
3.097
VAL14
3.204
GLY15
3.045
LYS16
2.688
SER17
2.961
ALA18
2.799
PHE28
3.310
VAL29
2.678
ASP30
2.865
GLU31
3.448
TYR32
3.629
ASP33
4.329
PRO34
3.319
|
|||||
| PDB ID: 6V9L Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [14] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.697
ALA11
3.869
GLY12
3.428
GLY13
3.020
VAL14
3.236
GLY15
3.054
LYS16
2.639
SER17
2.926
ALA18
2.729
PHE28
3.310
VAL29
2.682
ASP30
2.926
GLU31
3.455
TYR32
3.632
ASP33
4.297
PRO34
3.287
|
|||||
| PDB ID: 7VV8 Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [12] |
| PDB Sequence |
SMTEYKLVVV
9 GAGGVGKSAL19 TIQLIQNHFV29 DEYDPTIEDS39 YRKQVVIDGE49 TCLLDILDTA 59 GLEEYSAMRD69 QYMRTGEGFL79 CVFAINNTKS89 FEDIHQYREQ99 IKRVKDSDDV 109 PMVLVGNKCD119 LAARTVESRQ129 AQDLARSYGI139 PYIETSAKTR149 QGVEDAFYTL 159 VREIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.652
ALA11
3.959
GLY12
3.516
GLY13
3.035
VAL14
3.293
GLY15
2.992
LYS16
2.618
SER17
2.939
ALA18
2.795
LEU19
4.979
PHE28
3.256
VAL29
2.747
ASP30
2.830
GLU31
3.761
TYR32
2.438
ASP33
4.523
|
|||||
| PDB ID: 6CUO Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.73 Å | Mutation | Yes | [16] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.693
ALA11
3.840
GLY12
3.441
GLY13
3.049
VAL14
3.288
GLY15
3.090
LYS16
2.652
SER17
2.926
ALA18
2.777
PHE28
3.296
VAL29
2.663
ASP30
2.830
GLU31
3.432
TYR32
3.685
ASP33
4.314
PRO34
3.313
|
|||||
| PDB ID: 6CUR Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.73 Å | Mutation | Yes | [16] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.721
ALA11
3.856
GLY12
3.450
GLY13
3.019
VAL14
3.241
GLY15
3.070
LYS16
2.635
SER17
2.937
ALA18
2.768
PHE28
3.316
VAL29
2.670
ASP30
2.825
GLU31
3.475
TYR32
3.668
ASP33
4.300
PRO34
3.307
|
|||||
| PDB ID: 6BVI Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | Yes | [17] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.764
ALA11
3.877
GLY12
3.410
GLY13
3.117
VAL14
3.214
GLY15
3.065
LYS16
2.668
SER17
2.977
ALA18
2.812
PHE28
3.334
VAL29
2.679
ASP30
2.872
GLU31
3.534
TYR32
3.687
ASP33
4.352
PRO34
3.351
|
|||||
| PDB ID: 6BVJ Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [17] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEYSAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.740
ALA11
3.863
GLY12
3.376
GLY13
3.107
VAL14
3.204
GLY15
3.048
LYS16
2.660
SER17
2.953
ALA18
2.807
PHE28
3.295
VAL29
2.687
ASP30
2.820
GLU31
3.510
TYR32
3.676
ASP33
4.339
PRO34
3.351
|
|||||
| PDB ID: 6BVL Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | Yes | [17] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.756
ALA11
3.879
GLY12
3.435
GLY13
3.093
VAL14
3.219
GLY15
3.046
LYS16
2.658
SER17
2.955
ALA18
2.810
PHE28
3.313
VAL29
2.664
ASP30
2.821
GLU31
3.479
TYR32
3.646
ASP33
4.341
PRO34
3.358
|
|||||
| PDB ID: 6D5E Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.735
ALA11
3.868
GLY12
3.416
GLY13
3.111
VAL14
3.222
GLY15
3.036
LYS16
2.660
SER17
2.942
ALA18
2.774
PHE28
3.291
VAL29
2.672
ASP30
2.804
GLU31
3.512
TYR32
3.674
ASP33
4.328
PRO34
3.321
|
|||||
| PDB ID: 6D5J Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | Yes | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.686
ALA11
3.843
GLY12
3.393
GLY13
3.027
VAL14
3.223
GLY15
3.063
LYS16
2.599
SER17
2.937
ALA18
2.744
PHE28
3.280
VAL29
2.674
ASP30
2.836
GLU31
3.491
TYR32
3.647
ASP33
4.284
PRO34
3.295
|
|||||
| PDB ID: 6V9J Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods | ||||||
| Method | X-ray diffraction | Resolution | 1.76 Å | Mutation | No | [14] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.683
ALA11
3.829
GLY12
3.360
GLY13
3.016
VAL14
3.264
GLY15
3.100
LYS16
2.647
SER17
2.950
ALA18
2.740
PHE28
3.243
VAL29
2.679
ASP30
2.844
GLU31
3.456
TYR32
3.667
ASP33
4.286
PRO34
3.289
|
|||||
| PDB ID: 6BVK Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [17] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.718
ALA11
3.862
GLY12
3.403
GLY13
3.082
VAL14
3.236
GLY15
3.056
LYS16
2.673
SER17
2.955
ALA18
2.830
PHE28
3.316
VAL29
2.665
ASP30
2.817
GLU31
3.506
TYR32
3.646
ASP33
4.321
PRO34
3.375
|
|||||
| PDB ID: 6BVM Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [17] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.737
ALA11
3.900
GLY12
3.409
GLY13
3.072
VAL14
3.201
GLY15
3.059
LYS16
2.663
SER17
2.959
ALA18
2.833
PHE28
3.335
VAL29
2.672
ASP30
2.863
GLU31
3.474
TYR32
3.691
ASP33
4.332
PRO34
3.359
|
|||||
| PDB ID: 6D5H Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.780
ALA11
3.891
GLY12
3.405
GLY13
3.134
VAL14
3.233
GLY15
3.063
LYS16
2.675
SER17
3.006
ALA18
2.837
PHE28
3.293
VAL29
2.682
ASP30
2.894
GLU31
3.501
TYR32
3.741
ASP33
4.334
PRO34
3.374
|
|||||
| PDB ID: 6V94 Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [14] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.682
ALA11
3.818
GLY12
3.391
GLY13
3.044
VAL14
3.216
GLY15
3.076
LYS16
2.594
SER17
2.926
ALA18
2.771
PHE28
3.338
VAL29
2.667
ASP30
2.834
GLU31
3.447
TYR32
3.693
ASP33
4.306
PRO34
3.343
|
|||||
| PDB ID: 6V9O Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [18] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.713
ALA11
3.830
GLY12
3.409
GLY13
3.060
VAL14
3.260
GLY15
3.079
LYS16
2.615
SER17
2.930
ALA18
2.804
PHE28
3.312
VAL29
2.681
ASP30
2.878
GLU31
3.505
TYR32
3.647
ASP33
4.261
PRO34
3.319
|
|||||
| PDB ID: 6CUP Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.83 Å | Mutation | Yes | [16] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.710
ALA11
3.842
GLY12
3.486
GLY13
3.029
VAL14
3.231
GLY15
3.043
LYS16
2.604
SER17
2.999
ALA18
2.765
PHE28
3.319
VAL29
2.653
ASP30
2.821
GLU31
3.504
TYR32
3.698
ASP33
4.309
PRO34
3.312
|
|||||
| PDB ID: 1XCM Crystal structure of the GppNHp-bound H-Ras G60A mutant | ||||||
| Method | X-ray diffraction | Resolution | 1.84 Å | Mutation | Yes | [19] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAA 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQHK
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:57 or .A:58 or .A:60 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6V9F Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods | ||||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [14] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.710
ALA11
3.849
GLY12
3.403
GLY13
3.026
VAL14
3.222
GLY15
3.053
LYS16
2.664
SER17
2.918
ALA18
2.807
PHE28
3.336
VAL29
2.630
ASP30
2.903
GLU31
3.528
TYR32
3.682
ASP33
4.256
PRO34
3.331
|
|||||
| PDB ID: 6D5G Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 1.92 Å | Mutation | No | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGQ 61 EEASAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.733
ALA11
3.829
GLY12
3.385
GLY13
3.128
VAL14
3.223
GLY15
3.049
LYS16
2.700
SER17
2.954
ALA18
2.837
PHE28
3.294
VAL29
2.675
ASP30
2.804
GLU31
3.439
TYR32
3.661
ASP33
4.312
PRO34
3.369
|
|||||
| PDB ID: 5WFO Ligand-bound Ras:SOS:Ras complex | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [20] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.722
ALA11
3.886
GLY12
3.411
GLY13
3.034
VAL14
3.323
GLY15
3.093
LYS16
2.671
SER17
2.977
ALA18
2.841
PHE28
3.218
VAL29
2.640
ASP30
2.792
GLU31
3.480
TYR32
3.713
ASP33
4.257
PRO34
3.331
|
|||||
| PDB ID: 6D5V Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | No | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEASAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.735
ALA11
3.909
GLY12
3.441
GLY13
3.059
VAL14
3.296
GLY15
3.052
LYS16
2.660
SER17
2.971
ALA18
2.794
PHE28
3.312
VAL29
2.614
ASP30
2.865
GLU31
3.540
TYR32
3.733
ASP33
4.290
PRO34
3.370
|
|||||
| PDB ID: 5WFP Ligand-bound Ras:SOS:Ras complex | ||||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [20] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.724
ALA11
3.948
GLY12
3.412
GLY13
3.061
VAL14
3.360
GLY15
3.077
LYS16
2.683
SER17
3.008
ALA18
2.845
PHE28
3.385
VAL29
2.681
ASP30
2.858
GLU31
3.473
TYR32
3.657
ASP33
4.262
PRO34
3.341
|
|||||
| PDB ID: 6D5M Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [15] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEASAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.736
ALA11
3.907
GLY12
3.357
GLY13
3.040
VAL14
3.203
GLY15
3.006
LYS16
2.713
SER17
2.992
ALA18
2.858
PHE28
3.354
VAL29
2.685
ASP30
2.861
GLU31
3.494
TYR32
3.713
ASP33
4.269
PRO34
3.326
|
|||||
| PDB ID: 1LFD CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | Yes | [21] |
| PDB Sequence |
MTEYKLVVVG
210 AGGVGKSALT220 IQLIQNHFVD230 KYDPTIEDSY240 RKQVVIDGET250 CLLDILDTAG 260 QEEYSAMRDQ270 YMRTGEGFLC280 VFAINNTKSF290 EDIHQYREQI300 KRVKDSDDVP 310 MVLVGNKCDL320 AARTVESRQA330 QDLARSYGIP340 YIETSAKTRQ350 GVEDAFYTLV 360 REIRQHK
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .B:210 or .B:211 or .B:212 or .B:213 or .B:214 or .B:215 or .B:216 or .B:217 or .B:218 or .B:228 or .B:229 or .B:230 or .B:231 or .B:232 or .B:233 or .B:234 or .B:235 or .B:257 or .B:258 or .B:259 or .B:260 or .B:261 or .B:316 or .B:317 or .B:319 or .B:320 or .B:344 or .B:345 or .B:346 or .B:347; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY210
4.807
ALA211
3.896
GLY212
3.390
GLY213
3.100
VAL214
3.336
GLY215
3.137
LYS216
2.891
SER217
2.915
ALA218
2.944
PHE228
3.248
VAL229
4.116
ASP230
3.139
LYS231
3.564
TYR232
4.629
ASP233
4.431
|
|||||
| PDB ID: 5WFQ Ligand-bound Ras:SOS:Ras complex | ||||||
| Method | X-ray diffraction | Resolution | 2.26 Å | Mutation | No | [20] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.708
ALA11
3.921
GLY12
3.318
GLY13
3.100
VAL14
3.293
GLY15
3.057
LYS16
2.698
SER17
2.952
ALA18
2.823
PHE28
3.330
VAL29
2.665
ASP30
2.800
GLU31
3.458
TYR32
3.665
ASP33
4.268
PRO34
3.294
|
|||||
| PDB ID: 5WFR Ligand-bound Ras:SOS:Ras complex | ||||||
| Method | X-ray diffraction | Resolution | 2.46 Å | Mutation | No | [20] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.766
ALA11
3.985
GLY12
3.366
GLY13
3.122
VAL14
3.341
GLY15
3.058
LYS16
2.743
SER17
2.919
ALA18
2.854
PHE28
3.454
VAL29
2.759
ASP30
2.873
GLU31
3.568
TYR32
3.669
ASP33
4.344
PRO34
3.319
|
|||||
| PDB ID: 6D5W Ras:SOS:Ras in complex with a small molecule activator | ||||||
| Method | X-ray diffraction | Resolution | 2.48 Å | Mutation | Yes | [15] |
| PDB Sequence |
GMTEYKLVVV
9 GAGGVGKSAL19 TIQLIQNHFV29 DEYDPTIEDS39 YRKQVVIDGE49 TCLLDILDTA 59 GQEEASAMRD69 QYMRTGEGFL79 CVFAINNTKS89 FEDIHQYREQ99 IKRVKDSDDV 109 PMVLVGNKCD119 LAARTVESRQ129 AQDLARSYGI139 PYIETSAKTR149 QGVEDAFYTL 159 VREIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.923
ALA11
4.018
GLY12
3.398
GLY13
3.021
VAL14
3.598
GLY15
3.050
LYS16
2.727
SER17
3.283
ALA18
2.992
PHE28
3.495
VAL29
2.755
ASP30
3.101
GLU31
3.729
TYR32
3.497
ASP33
4.240
|
|||||
| PDB ID: 4NYI Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | ||||||
| Method | X-ray diffraction | Resolution | 2.96 Å | Mutation | Yes | [22] |
| PDB Sequence |
GMTEYKLVVV
9 GAGGVGKSAL19 TIQLIQNHFV29 DEYDPTIEDS39 YRKQVVIDGE49 TCLLDILDTA 59 GQEEASAMRD69 QYMRTGEGFL79 CVFAINNTKS89 FEDIHQYREQ99 IKRVKDSDDV 109 PMVLVGNKCD119 LAARTVESRQ129 AQDLARSYGI139 PYIETSAKTR149 QGVEDAFYTL 159 VREIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.762
ALA11
3.924
GLY12
3.654
GLY13
3.193
VAL14
3.331
GLY15
2.889
LYS16
2.608
SER17
3.000
ALA18
2.819
PHE28
3.403
VAL29
2.781
ASP30
3.193
GLU31
3.553
TYR32
3.660
ASP33
4.111
PRO34
3.382
|
|||||
| PDB ID: 5ZC6 Solution structure of H-RasT35S mutant protein in complex with KBFM123 | ||||||
| Method | Solution NMR | Resolution | N.A. | Mutation | Yes | [23] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPSIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:32 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:145 or .A:146 or .A:147 or .A:148; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY12
3.304
GLY13
3.707
VAL14
3.633
GLY15
2.475
LYS16
2.691
SER17
2.447
ALA18
3.252
LEU19
4.980
PHE28
1.806
VAL29
2.641
ASP30
2.730
TYR32
3.914
|
|||||
| PDB ID: 1CTQ STRUCTURE OF P21RAS IN COMPLEX WITH GPPNHP AT 100 K | ||||||
| Method | X-ray diffraction | Resolution | 1.26 Å | Mutation | No | [24] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.851
ALA11
3.853
GLY12
3.492
GLY13
3.129
VAL14
3.203
GLY15
3.061
LYS16
2.701
SER17
2.941
ALA18
2.815
PHE28
3.271
VAL29
2.765
ASP30
2.985
GLU31
3.836
TYR32
4.861
ASP33
4.402
PRO34
3.443
|
|||||
| PDB ID: 3K8Y Allosteric modulation of H-Ras GTPase | ||||||
| Method | X-ray diffraction | Resolution | 1.30 Å | Mutation | No | [25] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.785
ALA11
3.911
GLY12
3.460
GLY13
3.101
VAL14
3.227
GLY15
2.997
LYS16
2.633
SER17
2.946
ALA18
2.809
PHE28
3.225
VAL29
2.686
ASP30
2.817
GLU31
3.550
TYR32
3.773
ASP33
4.405
PRO34
3.431
|
|||||
| PDB ID: 3OIW H-RasG12V with allosteric switch in the "on" state | ||||||
| Method | X-ray diffraction | Resolution | 1.30 Å | Mutation | Yes | [26] |
| PDB Sequence |
MTEYKLVVVG
10 AVGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.770
ALA11
3.837
VAL12
3.578
GLY13
3.154
VAL14
3.189
GLY15
3.015
LYS16
2.664
SER17
2.954
ALA18
2.818
LEU19
4.993
PHE28
3.207
VAL29
2.663
ASP30
2.889
GLU31
3.583
TYR32
2.572
ASP33
4.394
|
|||||
| PDB ID: 3TGP Room temperature H-ras | ||||||
| Method | X-ray diffraction | Resolution | 1.31 Å | Mutation | No | [27] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.941
ALA11
4.065
GLY12
2.514
GLY13
2.383
VAL14
2.871
GLY15
2.347
LYS16
1.862
SER17
2.112
ALA18
2.099
LEU19
4.623
PHE28
3.121
VAL29
2.113
ASP30
2.026
GLU31
3.355
TYR32
4.493
ASP33
4.237
|
|||||
| PDB ID: 3OIU H-RasQ61L with allosteric switch in the "on" state | ||||||
| Method | X-ray diffraction | Resolution | 1.32 Å | Mutation | Yes | [26] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 LEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.760
ALA11
3.864
GLY12
3.512
GLY13
3.086
VAL14
3.246
GLY15
2.998
LYS16
2.664
SER17
2.971
ALA18
2.792
LEU19
4.987
PHE28
3.226
VAL29
2.631
ASP30
2.848
GLU31
3.553
TYR32
2.630
ASP33
4.362
|
|||||
| PDB ID: 4DLR H-Ras PEG 400/Ca(OAc)2, ordered off | ||||||
| Method | X-ray diffraction | Resolution | 1.32 Å | Mutation | No | [28] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDE70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.710
ALA11
3.828
GLY12
3.507
GLY13
3.098
VAL14
3.243
GLY15
3.019
LYS16
2.637
SER17
2.946
ALA18
2.806
PHE28
3.248
VAL29
2.646
ASP30
2.879
GLU31
3.435
TYR32
2.554
ASP33
4.356
PRO34
3.427
|
|||||
| PDB ID: 2RGB Crystal structure of H-RasQ61K-GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | Yes | [29] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 KEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.802
ALA11
3.873
GLY12
3.567
GLY13
3.030
VAL14
3.336
GLY15
3.041
LYS16
2.658
SER17
2.887
ALA18
2.796
PHE28
3.213
VAL29
2.673
ASP30
2.776
GLU31
3.494
TYR32
2.746
ASP33
4.409
PRO34
3.550
|
|||||
| PDB ID: 5P21 REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS | ||||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [30] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.930
ALA11
3.942
GLY12
3.572
GLY13
3.138
VAL14
3.325
GLY15
3.125
LYS16
2.677
SER17
2.899
ALA18
2.814
PHE28
3.275
VAL29
2.656
ASP30
3.211
GLU31
3.881
ASP33
4.465
PRO34
3.609
|
|||||
| PDB ID: 5WDP H-Ras mutant L120A bound to GMP-PNP at 277K | ||||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | Yes | [11] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDA120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.782
ALA11
3.880
GLY12
2.606
GLY13
1.972
VAL14
2.850
GLY15
2.267
LYS16
1.781
SER17
2.100
ALA18
1.987
LEU19
4.466
PHE28
2.809
VAL29
1.996
ASP30
1.990
GLU31
2.694
TYR32
1.766
ASP33
4.056
|
|||||
| PDB ID: 3I3S Crystal Structure of H-Ras with Thr50 replaced by Isoleucine | ||||||
| Method | X-ray diffraction | Resolution | 1.36 Å | Mutation | Yes | [31] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGEI50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .R:10 or .R:11 or .R:12 or .R:13 or .R:14 or .R:15 or .R:16 or .R:17 or .R:18 or .R:28 or .R:29 or .R:30 or .R:31 or .R:32 or .R:33 or .R:34 or .R:35 or .R:57 or .R:58 or .R:59 or .R:60 or .R:61 or .R:116 or .R:117 or .R:118 or .R:119 or .R:120 or .R:144 or .R:145 or .R:146 or .R:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.802
ALA11
3.894
GLY12
3.512
GLY13
3.130
VAL14
3.310
GLY15
3.057
LYS16
2.677
SER17
2.920
ALA18
2.831
PHE28
3.255
VAL29
2.660
ASP30
2.859
GLU31
3.493
TYR32
3.766
ASP33
4.376
PRO34
3.471
|
|||||
| PDB ID: 2RGE Crystal structure of H-Ras-GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [29] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 DQYMRTGEGF78 LCVFAINNTK88 SFEDIHQYRE98 QIKRVKDSDD108 VPMVLVGNKC 118 DLAARTVESR128 QAQDLARSYG138 IPYIETSAKT148 RQGVEDAFYT158 LVREIRQH |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.841
ALA11
3.918
GLY12
3.532
GLY13
3.070
VAL14
3.350
GLY15
3.067
LYS16
2.685
SER17
2.883
ALA18
2.819
PHE28
3.235
VAL29
2.697
ASP30
2.770
GLU31
3.482
TYR32
3.724
ASP33
4.426
|
|||||
| PDB ID: 3RS0 H-Ras soaked in neat cyclopentanol: one of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.752
ALA11
3.812
GLY12
3.433
GLY13
3.092
VAL14
3.251
GLY15
3.027
LYS16
2.674
SER17
2.960
ALA18
2.828
PHE28
3.215
VAL29
2.631
ASP30
2.939
GLU31
3.420
TYR32
2.541
ASP33
4.358
PRO34
3.442
|
|||||
| PDB ID: 3L8Z H-Ras wildtype new crystal form | ||||||
| Method | X-ray diffraction | Resolution | 1.44 Å | Mutation | No | [33] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.714
ALA11
3.837
GLY12
3.354
GLY13
3.058
VAL14
3.178
GLY15
2.988
LYS16
2.560
SER17
2.906
ALA18
2.752
LEU19
4.949
PHE28
3.118
VAL29
2.649
ASP30
2.785
GLU31
3.492
TYR32
3.788
ASP33
4.359
|
|||||
| PDB ID: 2RGG Crystal structure of H-RasQ61I-GppNHp, trigonal crystal form | ||||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | Yes | [29] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 RDQYMRTGEG77 FLCVFAINNT87 KSFEDIHQYR97 EQIKRVKDSD107 DVPMVLVGNK 117 CDLAARTVES127 RQAQDLARSY137 GIPYIETSAK147 TRQGVEDAFY157 TLVREIRQH |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.920
ALA11
3.925
GLY12
3.548
GLY13
3.068
VAL14
3.312
GLY15
3.095
LYS16
2.665
SER17
2.862
ALA18
2.841
PHE28
3.239
VAL29
2.914
ASP30
3.260
GLU31
3.903
TYR32
4.806
ASP33
4.378
|
|||||
| PDB ID: 1ZW6 Crystal Structure of the GTP-bound form of RasQ61G | ||||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | Yes | [34] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 LLDILDTAGG 61 EEYSAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLA121 ARTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.758
ALA11
3.837
GLY12
3.596
GLY13
2.998
VAL14
3.244
GLY15
3.032
LYS16
2.624
SER17
2.970
ALA18
2.825
LEU19
4.991
PHE28
3.217
VAL29
2.646
ASP30
2.849
GLU31
3.551
TYR32
2.571
ASP33
4.434
|
|||||
| PDB ID: 821P THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS | ||||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | Yes | [35] |
| PDB Sequence |
MTEYKLVVVG
10 APGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.990
ALA11
3.973
PRO12
3.369
GLY13
2.331
VAL14
2.812
GLY15
2.061
LYS16
1.670
SER17
1.983
ALA18
1.850
LEU19
4.498
PHE28
3.423
VAL29
2.008
ASP30
2.912
GLU31
2.501
TYR32
4.243
ASP33
3.781
|
|||||
| PDB ID: 3RS3 H-Ras soaked in neat hexane: 1 of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.52 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.730
ALA11
3.848
GLY12
3.466
GLY13
3.084
VAL14
3.274
GLY15
3.010
LYS16
2.665
SER17
2.929
ALA18
2.811
PHE28
3.182
VAL29
2.653
ASP30
2.869
GLU31
3.469
TYR32
2.613
ASP33
4.385
PRO34
3.489
|
|||||
| PDB ID: 4DLV H-Ras Set 2 CaCl2/DTT, ordered off | ||||||
| Method | X-ray diffraction | Resolution | 1.57 Å | Mutation | No | [28] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDE70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.770
ALA11
3.848
GLY12
3.434
GLY13
3.082
VAL14
3.287
GLY15
3.058
LYS16
2.631
SER17
2.913
ALA18
2.864
PHE28
3.221
VAL29
2.641
ASP30
2.789
GLU31
3.400
TYR32
2.724
ASP33
4.282
PRO34
3.391
|
|||||
| PDB ID: 4DLY Set 1 CaCl2/DTT, ordered off | ||||||
| Method | X-ray diffraction | Resolution | 1.57 Å | Mutation | No | [28] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDE70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.680
ALA11
3.870
GLY12
3.392
GLY13
3.091
VAL14
3.264
GLY15
2.995
LYS16
2.622
SER17
2.931
ALA18
2.822
PHE28
3.193
VAL29
2.629
ASP30
2.895
GLU31
3.440
TYR32
2.608
ASP33
4.388
PRO34
3.483
|
|||||
| PDB ID: 2RGC Crystal structure of H-RasQ61V-GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | Yes | [29] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 VEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.849
ALA11
3.875
GLY12
3.609
GLY13
3.010
VAL14
3.312
GLY15
3.036
LYS16
2.696
SER17
2.911
ALA18
2.790
PHE28
3.201
VAL29
2.676
ASP30
2.809
GLU31
3.522
TYR32
2.779
ASP33
4.382
PRO34
3.501
|
|||||
| PDB ID: 3RRY H-Ras crosslinked control, soaked in aqueous solution: one of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.771
ALA11
3.857
GLY12
3.428
GLY13
3.080
VAL14
3.269
GLY15
2.999
LYS16
2.685
SER17
2.913
ALA18
2.809
LEU19
4.984
PHE28
3.201
VAL29
2.634
ASP30
2.832
GLU31
3.511
TYR32
2.670
ASP33
4.365
|
|||||
| PDB ID: 3RRZ H-Ras in 70% glycerol: one of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.760
ALA11
3.894
GLY12
3.523
GLY13
3.117
VAL14
3.231
GLY15
2.987
LYS16
2.631
SER17
2.910
ALA18
2.826
PHE28
3.142
VAL29
2.681
ASP30
2.884
GLU31
3.572
TYR32
2.527
ASP33
4.436
PRO34
3.534
|
|||||
| PDB ID: 3RSO H-Ras soaked in 20% S,R,S-bisfuranol: 1 of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.779
ALA11
3.894
GLY12
3.443
GLY13
3.089
VAL14
3.275
GLY15
2.968
LYS16
2.640
SER17
2.900
ALA18
2.845
PHE28
3.225
VAL29
2.643
ASP30
2.974
GLU31
3.519
TYR32
2.624
ASP33
4.397
PRO34
3.456
|
|||||
| PDB ID: 4DLU H-Ras Set 1 Ca(OAc)2, on | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [28] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.713
ALA11
3.884
GLY12
3.364
GLY13
3.058
VAL14
3.196
GLY15
3.016
LYS16
2.604
SER17
2.823
ALA18
2.755
LEU19
4.995
PHE28
3.243
VAL29
2.712
ASP30
2.826
GLU31
3.618
TYR32
3.721
ASP33
4.413
|
|||||
| PDB ID: 4DLZ H-Ras Set 2 Ca(OAc)2/DTE, ordered off | ||||||
| Method | X-ray diffraction | Resolution | 1.66 Å | Mutation | No | [28] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDE70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.710
ALA11
3.830
GLY12
3.451
GLY13
3.080
VAL14
3.209
GLY15
3.001
LYS16
2.597
SER17
2.938
ALA18
2.842
PHE28
3.184
VAL29
2.613
ASP30
2.901
GLU31
3.440
TYR32
2.555
ASP33
4.360
PRO34
3.472
|
|||||
| PDB ID: 3RS5 H-Ras soaked in 55% dimethylformamide: 1 of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.68 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.793
ALA11
3.872
GLY12
3.473
GLY13
3.114
VAL14
3.244
GLY15
3.033
LYS16
2.659
SER17
2.978
ALA18
2.857
PHE28
3.146
VAL29
2.663
ASP30
2.904
GLU31
3.506
TYR32
2.686
ASP33
4.421
PRO34
3.435
|
|||||
| PDB ID: 1LF0 Crystal Structure of RasA59G in the GTP-bound form | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [36] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTGG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.636
ALA11
3.913
GLY12
3.311
GLY13
3.141
VAL14
3.311
GLY15
3.104
LYS16
2.481
SER17
2.954
ALA18
2.841
PHE28
3.141
VAL29
2.696
ASP30
2.916
GLU31
3.585
TYR32
3.529
ASP33
4.433
|
|||||
| PDB ID: 3RS4 H-Ras soaked in 60% 1,6-hexanediol: 1 of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYMRDQYM72 RTGEGFLCVF82 AINNTKSFED92 IHQYREQIKR102 VKDSDDVPMV 112 LVGNKCDLAA122 RTVESRQAQD132 LARSYGIPYI142 ETSAKTRQGV152 EDAFYTLVRE 162 IRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.778
ALA11
3.860
GLY12
3.445
GLY13
3.095
VAL14
3.294
GLY15
3.044
LYS16
2.643
SER17
3.002
ALA18
2.849
PHE28
3.151
VAL29
2.678
ASP30
2.927
GLU31
3.533
TYR32
2.681
ASP33
4.385
PRO34
3.554
|
|||||
| PDB ID: 3RS7 H-Ras soaked in 50% isopropanol: 1 of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYRDQYMR73 TGEGFLCVFA83 INNTKSFEDI93 HQYREQIKRV103 KDSDDVPMVL 113 VGNKCDLAAR123 TVESRQAQDL133 ARSYGIPYIE143 TSAKTRQGVE153 DAFYTLVREI 163 RQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.787
ALA11
3.876
GLY12
3.455
GLY13
3.108
VAL14
3.295
GLY15
3.009
LYS16
2.659
SER17
2.944
ALA18
2.849
PHE28
3.232
VAL29
2.707
ASP30
2.886
GLU31
3.528
TYR32
2.784
ASP33
4.389
PRO34
3.535
|
|||||
| PDB ID: 3RSL H-Ras soaked in 90% R,S,R-bisfuranol: one of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP110 MVLVGNKCDL 120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV160 REIRQH |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.750
ALA11
3.927
GLY12
3.475
GLY13
3.015
VAL14
3.206
GLY15
2.959
LYS16
2.694
SER17
2.965
ALA18
2.783
LEU19
5.000
PHE28
3.150
VAL29
2.641
ASP30
2.925
GLU31
3.517
TYR32
2.585
ASP33
4.337
|
|||||
| PDB ID: 4DLT H-Ras Set 2 Ca(OAc)2, on | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [28] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.717
ALA11
3.885
GLY12
3.422
GLY13
3.109
VAL14
3.180
GLY15
3.033
LYS16
2.630
SER17
2.928
ALA18
2.798
LEU19
4.996
PHE28
3.198
VAL29
2.733
ASP30
2.859
GLU31
3.608
TYR32
2.702
ASP33
4.441
|
|||||
| PDB ID: 7OGC GTPase HRAS under 650 MPa pressure | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [37] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.928
ALA11
3.761
GLY12
3.360
GLY13
3.161
VAL14
3.210
GLY15
3.112
LYS16
2.738
SER17
2.858
ALA18
2.845
PHE28
3.273
VAL29
2.770
ASP30
3.015
GLU31
3.704
TYR32
4.856
ASP33
4.448
PRO34
3.407
|
|||||
| PDB ID: 7VVG Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [12] |
| PDB Sequence |
MTEYKLVVVG
10 AVGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.697
ALA11
3.776
VAL12
3.552
GLY13
3.045
VAL14
3.185
GLY15
2.983
LYS16
2.652
SER17
2.923
ALA18
2.749
LEU19
4.980
PHE28
3.294
VAL29
2.782
ASP30
2.826
GLU31
3.779
TYR32
2.518
ASP33
4.487
|
|||||
| PDB ID: 4DLW H-Ras Set 2 Ca(OAc)2/DTT, on | ||||||
| Method | X-ray diffraction | Resolution | 1.72 Å | Mutation | No | [28] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.735
ALA11
3.867
GLY12
3.323
GLY13
3.091
VAL14
3.199
GLY15
3.006
LYS16
2.645
SER17
2.960
ALA18
2.812
PHE28
3.183
VAL29
2.679
ASP30
2.908
GLU31
3.533
TYR32
2.969
ASP33
4.370
PRO34
3.370
|
|||||
| PDB ID: 4DLX H-Ras Set 1 CaCl2/DTE, ordered off | ||||||
| Method | X-ray diffraction | Resolution | 1.73 Å | Mutation | No | [28] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDE70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.765
ALA11
3.849
GLY12
3.534
GLY13
3.024
VAL14
3.282
GLY15
3.033
LYS16
2.665
SER17
2.884
ALA18
2.830
PHE28
3.230
VAL29
2.637
ASP30
2.869
GLU31
3.439
TYR32
2.606
ASP33
4.353
PRO34
3.417
|
|||||
| PDB ID: 7OG9 GTPase HRAS under ambient pressure | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [37] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.815
ALA11
3.983
GLY12
3.519
GLY13
3.047
VAL14
3.363
GLY15
3.152
LYS16
2.651
SER17
2.991
ALA18
2.826
PHE28
3.325
VAL29
2.663
ASP30
3.308
GLU31
3.670
TYR32
4.829
ASP33
4.368
PRO34
3.538
|
|||||
| PDB ID: 7JIF HRAS A59T GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 1.76 Å | Mutation | Yes | [38] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTTG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.823
ALA11
3.924
GLY12
3.393
GLY13
3.062
VAL14
3.310
GLY15
3.074
LYS16
2.604
SER17
3.008
ALA18
2.819
PHE28
3.386
VAL29
2.753
ASP30
3.256
GLU31
3.640
TYR32
4.668
ASP33
4.513
PRO34
3.691
|
|||||
| PDB ID: 2CL0 CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [39] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 ECDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKSDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .X:10 or .X:11 or .X:12 or .X:13 or .X:14 or .X:15 or .X:16 or .X:17 or .X:18 or .X:28 or .X:29 or .X:30 or .X:31 or .X:32 or .X:33 or .X:35 or .X:57 or .X:58 or .X:59 or .X:60 or .X:63 or .X:116 or .X:117 or .X:118 or .X:119 or .X:120 or .X:144 or .X:145 or .X:146 or .X:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.804
ALA11
3.969
GLY12
3.282
GLY13
3.137
VAL14
3.331
GLY15
3.042
LYS16
2.695
SER17
2.954
ALA18
2.815
PHE28
3.236
VAL29
2.746
ASP30
2.947
GLU31
3.631
CYS32
3.801
ASP33
3.670
|
|||||
| PDB ID: 3DDC Crystal Structure of NORE1A in Complex with RAS | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [40] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVE30 KYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.882
ALA11
3.969
GLY12
3.430
GLY13
3.152
VAL14
3.293
GLY15
3.149
LYS16
2.650
SER17
2.908
ALA18
2.856
PHE28
3.131
VAL29
2.592
GLU30
2.857
LYS31
3.611
TYR32
3.663
ASP33
4.296
PRO34
3.377
|
|||||
| PDB ID: 3K9L Allosteric modulation of H-Ras GTPase | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [41] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EFDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYMRTGEG77 FLCVFAINNT87 KSFEDIHQYR97 EQIKRVKDSD107 DVPMVLVGNK 117 CDLAARTVES127 RQAQDLARSY137 GIPYIETSAK147 TRQGVEDAFY157 TLVREIRQH |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.766
ALA11
3.911
GLY12
3.134
GLY13
3.107
VAL14
3.144
GLY15
3.129
LYS16
2.542
SER17
2.951
ALA18
2.804
PHE28
3.194
VAL29
2.723
ASP30
2.758
GLU31
4.262
PHE32
3.616
ASP33
4.586
PRO34
3.481
|
|||||
| PDB ID: 7OGF GTPase HRAS mutant D33K under 900 MPa pressure | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [37] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYKPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.560
ALA11
3.699
GLY12
3.664
GLY13
3.206
VAL14
3.324
GLY15
3.270
LYS16
2.487
SER17
2.730
ALA18
2.896
PHE28
3.284
VAL29
4.253
ASP30
3.032
GLU31
3.059
TYR32
2.563
LYS33
4.205
PRO34
4.002
|
|||||
| PDB ID: 4DLS H-Ras Set 1 CaCl2 'Mixed' | ||||||
| Method | X-ray diffraction | Resolution | 1.82 Å | Mutation | No | [28] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.685
ALA11
3.848
GLY12
3.576
GLY13
3.052
VAL14
3.328
GLY15
3.123
LYS16
2.669
SER17
2.925
ALA18
2.761
LEU19
4.976
PHE28
3.230
VAL29
2.739
ASP30
3.132
GLU31
3.597
TYR32
2.468
ASP33
4.256
|
|||||
| PDB ID: 3OIV H-RasG12V with allosteric switch in the "off" state | ||||||
| Method | X-ray diffraction | Resolution | 1.84 Å | Mutation | Yes | [26] |
| PDB Sequence |
MTEYKLVVVG
10 AVGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 MRDQYMRTGE76 GFLCVFAINN86 TKSFEDIHQY96 REQIKRVKDS106 DDVPMVLVGN 116 KCDLAARTVE126 SRQAQDLARS136 YGIPYIETSA146 KTRQGVEDAF156 YTLVREIRQH 166
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.732
ALA11
3.818
VAL12
3.532
GLY13
3.111
VAL14
3.228
GLY15
2.988
LYS16
2.630
SER17
2.966
ALA18
2.812
PHE28
3.169
VAL29
2.604
ASP30
2.916
GLU31
3.469
TYR32
2.630
ASP33
4.442
|
|||||
| PDB ID: 3RS2 H-Ras soaked in 50% 2,2,2-trifluoroethanol: one of 10 in MSCS set | ||||||
| Method | X-ray diffraction | Resolution | 1.84 Å | Mutation | No | [32] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.705
ALA11
3.852
GLY12
3.355
GLY13
3.125
VAL14
3.261
GLY15
3.051
LYS16
2.677
SER17
2.944
ALA18
2.816
PHE28
3.162
VAL29
2.599
ASP30
2.855
GLU31
3.428
TYR32
2.736
ASP33
4.399
PRO34
3.475
|
|||||
| PDB ID: 3LBH Ras soaked in Calcium Acetate | ||||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [25] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.690
ALA11
3.877
GLY12
3.397
GLY13
3.168
VAL14
3.253
GLY15
3.064
LYS16
2.547
SER17
2.895
ALA18
2.829
LEU19
4.995
PHE28
3.265
VAL29
2.741
ASP30
2.766
GLU31
3.641
TYR32
3.822
ASP33
4.522
|
|||||
| PDB ID: 7OGB GTPase HRAS under 500 MPa pressure | ||||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [37] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.765
ALA11
3.806
GLY12
3.345
GLY13
3.124
VAL14
3.128
GLY15
3.027
LYS16
2.643
SER17
2.790
ALA18
2.969
PHE28
3.255
VAL29
2.570
ASP30
2.760
GLU31
3.344
TYR32
4.563
ASP33
4.452
PRO34
3.402
|
|||||
| PDB ID: 3LBN Ras soaked in Magnesium Acetate | ||||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | No | [25] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.712
ALA11
3.859
GLY12
3.363
GLY13
3.137
VAL14
3.266
GLY15
3.012
LYS16
2.652
SER17
2.949
ALA18
2.829
PHE28
3.192
VAL29
2.722
ASP30
2.855
GLU31
3.657
TYR32
2.925
ASP33
4.488
PRO34
3.362
|
|||||
| PDB ID: 4XVQ H-Ras Y137E | ||||||
| Method | X-ray diffraction | Resolution | 1.89 Å | Mutation | Yes | [42] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QYSAMRDQYM72 RTGEGFLCVF82 AINNTKSFED92 IHQYREQIKR102 VKDSDDVPMV 112 LVGNKCDLAA122 RTVESRQAQD132 LARSEGIPYI142 ETSAKTRQGV152 EDAFYTLVRE 162 IRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
3.860
GLY12
3.459
GLY13
3.176
VAL14
3.244
GLY15
3.115
LYS16
2.693
SER17
2.919
ALA18
2.821
PHE28
3.298
VAL29
4.444
ASP30
3.171
GLU31
3.350
TYR32
4.732
ASP33
4.246
PRO34
3.617
|
|||||
| PDB ID: 2RGA Crystal structure of H-RasQ61I-GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [29] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 IEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.851
ALA11
3.858
GLY12
3.527
GLY13
2.954
VAL14
3.229
GLY15
3.027
LYS16
2.750
SER17
2.895
ALA18
2.796
PHE28
3.162
VAL29
2.657
ASP30
2.832
GLU31
3.616
TYR32
2.664
ASP33
4.373
PRO34
3.537
|
|||||
| PDB ID: 6E6C HRAS G13D bound to GppNHp (H13GNP) | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [43] |
| PDB Sequence |
MTEYKLVVVG
10 AGDVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 EYSAMRDQYM72 RTGEGFLCVF82 AINNTKSFED92 IHQYREQIKR102 VKDSDDVPMV 112 LVGNKCDLAA122 RTVESRQAQD132 LARSYGIPYI142 ETSAKTRQGV152 EDAFYTLVRE 162 IRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:33 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
3.967
GLY12
3.311
ASP13
3.087
VAL14
3.237
GLY15
2.988
LYS16
2.731
SER17
2.994
ALA18
2.806
PHE28
3.366
VAL29
2.807
ASP30
3.486
ASP33
3.500
ASP57
4.832
|
|||||
| PDB ID: 7OGA GTPase HRAS under 200 MPa pressure | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [37] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.839
ALA11
3.909
GLY12
3.439
GLY13
3.070
VAL14
3.295
GLY15
3.082
LYS16
2.626
SER17
2.955
ALA18
2.811
PHE28
3.120
VAL29
2.658
ASP30
3.253
GLU31
3.662
TYR32
4.780
ASP33
4.151
PRO34
3.430
|
|||||
| PDB ID: 4RSG Neutron crystal structure of Ras bound to the GTP analogue GppNHp | ||||||
| Method | Neutron diffraction | Resolution | 1.91 Å | Mutation | No | [44] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QAMRDQYMRT74 GEGFLCVFAI84 NNTKSFEDIH94 QYREQIKRVK104 DSDDVPMVLV 114 GNKCDLAART124 VESRQAQDLA134 RSYGIPYIET144 SAKTRQGVED154 AFYTLVREIR 164 QH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147 or .A:148; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
3.690
GLY12
2.388
GLY13
2.425
VAL14
2.563
GLY15
2.282
LYS16
1.759
SER17
2.021
ALA18
1.903
LEU19
4.525
PHE28
2.702
VAL29
1.577
ASP30
2.288
GLU31
3.185
TYR32
3.363
ASP33
3.984
PRO34
2.548
|
|||||
| PDB ID: 6E6P HRAS G13D bound to GppNHp (Ha,b,c13GNP) | ||||||
| Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | Yes | [43] |
| PDB Sequence |
MTEYKLVVVG
10 AGDVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAM 67 RDQYMRTGEG77 FLCVFAINNT87 KSFEDIHQYR97 EQIKRVKDSD107 DVPMVLVGNK 117 CDLAARTVES127 RQAQDLARSY137 GIPYIETSAK147 TRQGVEDAFY157 TLVREIRQH |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:35 or .A:57 or .A:58 or .A:59 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
4.002
GLY12
3.462
ASP13
3.085
VAL14
3.435
GLY15
3.104
LYS16
2.702
SER17
2.886
ALA18
2.802
PHE28
3.278
VAL29
2.751
ASP30
3.684
GLU31
4.593
THR35
4.387
|
|||||
| PDB ID: 7OGD GTPase HRAS mutant D33K under ambient pressure | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | Yes | [37] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYKPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.896
ALA11
4.001
GLY12
3.446
GLY13
3.048
VAL14
3.505
GLY15
3.050
LYS16
2.607
SER17
2.903
ALA18
2.824
PHE28
3.324
VAL29
2.704
ASP30
3.373
GLU31
3.687
TYR32
4.874
LYS33
4.291
PRO34
3.410
|
|||||
| PDB ID: 7JIH HRAS A59E GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | Yes | [38] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 DSYRKQVVID47 GETCLLDILD57 TEGQEEYSAM 67 RDQYMRTGEG77 FLCVFAINNT87 KSFEDIHQYR97 EQIKRVKDSD107 DVPMVLVGNK 117 CDLAARTVES127 RQAQDLARSY137 GIPYIETSAK147 TRQGVEDAFY157 TLVREIRQH |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.933
ALA11
3.909
GLY12
3.451
GLY13
3.272
VAL14
3.275
GLY15
3.070
LYS16
2.732
SER17
2.807
ALA18
2.744
PHE28
3.284
VAL29
4.429
ASP30
3.363
ASP57
4.679
|
|||||
| PDB ID: 1P2T H-Ras 166 in Aqueous mother liqour, RT | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [45] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEMRDQYMRT74 GEGFLCVFAI84 NNTKSFEDIH94 QYREQIKRVK104 DSDDVPMVLV 114 GNKCDLAART124 VESRQAQDLA134 RSYGIPYIET144 SAKTRQGVED154 AFYTLVREIR 164 QH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.930
ALA11
3.869
GLY12
3.453
GLY13
3.073
VAL14
3.195
GLY15
3.073
LYS16
2.627
SER17
2.941
ALA18
2.854
PHE28
3.277
VAL29
2.837
ASP30
3.337
GLU31
4.088
TYR32
4.893
ASP33
4.455
PRO34
3.677
|
|||||
| PDB ID: 1P2U H-Ras in 50% isopropanol | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [45] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEMRDQYMRT74 GEGFLCVFAI84 NNTKSFEDIH94 QYREQIKRVK104 DSDDVPMVLV 114 GNKCDLAART124 VESRQAQDLA134 RSYGIPYIET144 SAKTRQGVED154 AFYTLVREIR 164 QH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.923
ALA11
3.929
GLY12
3.417
GLY13
3.085
VAL14
3.209
GLY15
3.058
LYS16
2.632
SER17
2.912
ALA18
2.916
PHE28
3.182
VAL29
2.718
ASP30
3.340
GLU31
3.787
TYR32
4.914
ASP33
4.284
PRO34
3.592
|
|||||
| PDB ID: 2RGD Crystal structure of H-RasQ61L-GppNHp | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [29] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 LEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.809
ALA11
3.855
GLY12
3.539
GLY13
2.979
VAL14
3.306
GLY15
3.043
LYS16
2.719
SER17
2.899
ALA18
2.793
LEU19
4.979
PHE28
3.189
VAL29
2.726
ASP30
2.842
GLU31
3.582
TYR32
2.807
ASP33
4.472
|
|||||
| PDB ID: 3K9N Allosteric modulation of H-Ras GTPase | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [25] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EFDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QYSAMRDQYM72 RTGEGFLCVF82 AINNTKSFED92 IHQYREQIKR102 VKDSDDVPMV 112 LVGNKCDLAA122 RTVESRQAQD132 LARSYGIPYI142 ETSAKTRQGV152 EDAFYTLVRE 162 IRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:37 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.897
ALA11
3.927
GLY12
3.279
GLY13
3.061
VAL14
3.352
GLY15
3.097
LYS16
2.730
SER17
3.053
ALA18
2.882
PHE28
3.304
VAL29
3.904
ASP30
2.675
GLU31
2.846
PHE32
3.889
|
|||||
| PDB ID: 721P THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [46] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 LEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.865
ALA11
3.928
GLY12
3.351
GLY13
3.083
VAL14
3.303
GLY15
3.119
LYS16
2.727
SER17
3.052
ALA18
2.875
PHE28
3.454
VAL29
2.661
ASP30
3.374
GLU31
3.863
TYR32
4.815
ASP33
4.439
|
|||||
| PDB ID: 3L8Y Complex of Ras with cyclen | ||||||
| Method | X-ray diffraction | Resolution | 2.02 Å | Mutation | No | [33] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.730
ALA11
3.751
GLY12
3.429
GLY13
3.101
VAL14
3.270
GLY15
3.122
LYS16
2.523
SER17
2.872
ALA18
2.857
PHE28
3.164
VAL29
2.548
ASP30
2.751
GLU31
3.530
TYR32
2.584
ASP33
4.290
PRO34
3.485
|
|||||
| PDB ID: 4XVR H-Ras Y137F | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | Yes | [42] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QMRDQYMRTG75 EGFLCVFAIN85 NTKSFEDIHQ95 YREQIKRVKD105 SDDVPMVLVG 115 NKCDLAARTV125 ESRQAQDLAR135 SFGIPYIETS145 AKTRQGVEDA155 FYTLVREIRQ 165 H
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
3.775
GLY12
3.670
GLY13
3.175
VAL14
3.173
GLY15
3.093
LYS16
2.550
SER17
2.939
ALA18
2.955
PHE28
3.436
VAL29
4.252
ASP30
2.974
GLU31
3.548
TYR32
4.857
ASP33
4.364
PRO34
3.525
|
|||||
| PDB ID: 3LBI Ras soaked in Magnesium Acetate and back soaked in Calcium Acetate | ||||||
| Method | X-ray diffraction | Resolution | 2.09 Å | Mutation | No | [25] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.795
ALA11
3.804
GLY12
3.518
GLY13
3.143
VAL14
3.227
GLY15
3.028
LYS16
2.590
SER17
2.840
ALA18
2.870
PHE28
3.123
VAL29
2.781
ASP30
2.751
GLU31
3.621
TYR32
3.354
ASP33
4.388
PRO34
3.434
|
|||||
| PDB ID: 7OGE GTPase HRAS mutant D33K under 200 MPa pressure | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | Yes | [37] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYKPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.854
ALA11
3.990
GLY12
3.353
GLY13
3.153
VAL14
3.411
GLY15
3.046
LYS16
2.735
SER17
2.877
ALA18
2.686
LEU19
4.953
PHE28
3.241
VAL29
2.715
ASP30
3.340
GLU31
3.408
TYR32
4.714
LYS33
4.223
|
|||||
| PDB ID: 5WPL KRas G12V, bound to GppNHp and miniprotein 225-11 | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | Yes | [47] |
| PDB Sequence |
TEYKLVVVGA
11 VGVGKSALTI21 QLIQNHFVDE31 YDPTIEDSYR41 KQVVIDGETC51 LLDILDTAGQ 61 EEYSAMRDQY71 MRTGEGFLCV81 FAINNTKSFE91 DIHQYREQIK101 RVKDSDDVPM 111 VLVGNKCDLP121 SRTVESRQAQ131 DLARSYGIPY141 IETSAKTRQG151 VEDAFYTLVR 161 EIRKH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.917
ALA11
3.889
VAL12
3.268
GLY13
3.174
VAL14
3.429
GLY15
3.030
LYS16
2.720
SER17
3.017
ALA18
2.829
PHE28
3.539
ASP57
4.579
THR58
4.420
|
|||||
| PDB ID: 1NVV Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | ||||||
| Method | X-ray diffraction | Resolution | 2.18 Å | Mutation | Yes | [48] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEASAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.891
ALA11
3.893
GLY12
3.438
GLY13
3.019
VAL14
3.260
GLY15
2.997
LYS16
2.623
SER17
3.005
ALA18
2.894
PHE28
3.304
VAL29
2.671
ASP30
2.963
GLU31
3.698
TYR32
3.717
ASP33
4.466
PRO34
3.466
|
|||||
| PDB ID: 421P THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | Yes | [46] |
| PDB Sequence |
MTEYKLVVVG
10 ARGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
3.878
ARG12
2.597
GLY13
2.984
VAL14
3.275
GLY15
2.896
LYS16
2.751
SER17
3.151
ALA18
3.042
PHE28
3.317
VAL29
2.748
ASP30
3.343
GLU31
3.326
ASP33
4.415
PRO34
3.612
|
|||||
| PDB ID: 1AGP THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [35] |
| PDB Sequence |
MTEYKLVVVG
10 ADGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147 or .A:148; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.652
ALA11
3.736
ASP12
1.899
GLY13
2.456
VAL14
3.223
GLY15
2.343
LYS16
2.043
SER17
2.134
ALA18
2.227
LEU19
4.795
PHE28
3.266
VAL29
1.622
ASP30
2.880
GLU31
2.663
TYR32
2.708
ASP33
3.858
PRO34
3.480
|
|||||
| PDB ID: 1P2V H-RAS 166 in 60 % 1,6 hexanediol | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [45] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.809
ALA11
3.991
GLY12
3.338
GLY13
3.028
VAL14
3.225
GLY15
2.903
LYS16
2.623
SER17
2.838
ALA18
2.769
PHE28
3.177
VAL29
2.801
ASP30
3.224
GLU31
4.065
TYR32
4.780
ASP33
4.474
PRO34
3.782
|
|||||
| PDB ID: 221P THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [46] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEESY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:33 or .A:34 or .A:35 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.960
ALA11
3.801
GLY12
3.317
GLY13
3.132
VAL14
3.163
GLY15
3.094
LYS16
2.662
SER17
3.168
ALA18
2.809
PHE28
3.381
VAL29
2.843
ASP30
3.192
GLU31
3.843
ASP33
4.571
|
|||||
| PDB ID: 7JIG HRAS A59T GppNHp crystal 2 | ||||||
| Method | X-ray diffraction | Resolution | 2.32 Å | Mutation | Yes | [38] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTTG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.735
ALA11
3.880
GLY12
3.246
GLY13
3.032
VAL14
3.200
GLY15
3.055
LYS16
2.388
SER17
2.778
ALA18
2.652
LEU19
4.973
PHE28
3.257
VAL29
3.882
ASP30
3.064
GLU31
3.561
TYR32
4.631
|
|||||
| PDB ID: 621P THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [46] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 HEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
3.690
GLY12
3.104
GLY13
3.210
VAL14
2.812
GLY15
3.054
LYS16
2.940
SER17
3.057
ALA18
3.039
PHE28
3.329
VAL29
2.710
ASP30
2.764
GLU31
3.478
TYR32
4.945
ASP33
4.662
PRO34
3.540
|
|||||
| PDB ID: 1P2S H-Ras 166 in 50% 2,2,2 triflouroethanol | ||||||
| Method | X-ray diffraction | Resolution | 2.45 Å | Mutation | No | [45] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.994
ALA11
3.898
GLY12
3.285
GLY13
2.929
VAL14
3.182
GLY15
3.014
LYS16
2.647
SER17
2.952
ALA18
2.890
PHE28
3.195
VAL29
3.081
ASP30
3.198
GLU31
4.023
TYR32
4.653
ASP33
4.503
|
|||||
| PDB ID: 4G0N Crystal Structure of wt H-Ras-GppNHp bound to the RBD of Raf Kinase | ||||||
| Method | X-ray diffraction | Resolution | 2.45 Å | Mutation | No | [49] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEAMRDQYM72 RTGEGFLCVF82 AINNTKSFED92 IHQYREQIKR102 VKDSDDVPMV 112 LVGNKCDLAA122 RTVESRQAQD132 LARSYGIPYI142 ETSAKTRQGV152 EDAFYTLVRE 162 IRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.899
ALA11
3.801
GLY12
3.377
GLY13
3.134
VAL14
3.399
GLY15
3.098
LYS16
2.743
SER17
2.936
ALA18
2.826
PHE28
3.396
VAL29
2.757
ASP30
3.004
GLU31
3.558
TYR32
3.703
ASP33
4.273
PRO34
3.471
|
|||||
| PDB ID: 1NVW Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [48] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.856
ALA11
3.976
GLY12
3.578
GLY13
3.092
VAL14
3.444
GLY15
3.105
LYS16
2.838
SER17
2.835
ALA18
2.782
PHE28
3.363
VAL29
2.830
ASP30
3.267
GLU31
3.701
TYR32
3.002
ASP33
4.415
PRO34
3.653
|
|||||
| PDB ID: 7JHP Crystal structure of HRas in complex with the Ras-binding and cysteine-rich domains of CRaf-kinase | ||||||
| Method | X-ray diffraction | Resolution | 2.77 Å | Mutation | Yes | [50] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYCEQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:118 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.692
ALA11
3.740
GLY12
3.470
GLY13
3.001
VAL14
3.358
GLY15
2.987
LYS16
2.389
SER17
3.092
ALA18
2.829
PHE28
3.696
VAL29
2.853
ASP30
3.005
GLU31
3.705
TYR32
2.575
ASP33
4.369
PRO34
3.830
|
|||||
| PDB ID: 4NYJ Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | ||||||
| Method | X-ray diffraction | Resolution | 2.85 Å | Mutation | Yes | [22] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEASAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:10 or .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.932
ALA11
4.057
GLY12
3.733
GLY13
3.083
VAL14
3.503
GLY15
3.098
LYS16
2.608
SER17
3.040
ALA18
2.927
PHE28
3.479
VAL29
2.730
ASP30
3.045
GLU31
3.689
TYR32
3.620
ASP33
4.398
PRO34
3.473
|
|||||
| PDB ID: 1IAQ C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE | ||||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | Yes | [51] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD38 SYRKQVVIDG48 ETCLLDILDT58 AGQYMRTGEG 77 FLCVFAINNT87 KSFEDIHQYR97 EQIKRVKDSD107 DVPMVLVGNK117 CDLAARTVES 127 RQAQDLARSY137 GIPYIETSAK147 TRQGVEDAFY157 TLVREIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:58 or .A:59 or .A:60 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
4.707
GLY12
3.532
GLY13
2.791
VAL14
3.293
GLY15
2.797
LYS16
2.637
SER17
3.443
ALA18
2.890
PHE28
3.298
VAL29
3.398
THR58
4.602
|
|||||
| PDB ID: 1HE8 Ras G12V - PI 3-kinase gamma complex | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [52] |
| PDB Sequence |
MTEYKLVVVG
10 AVGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .B:10 or .B:11 or .B:12 or .B:13 or .B:14 or .B:15 or .B:16 or .B:17 or .B:18 or .B:19 or .B:28 or .B:29 or .B:30 or .B:31 or .B:32 or .B:33 or .B:34 or .B:35 or .B:57 or .B:58 or .B:59 or .B:60 or .B:61 or .B:116 or .B:117 or .B:118 or .B:119 or .B:120 or .B:144 or .B:145 or .B:146 or .B:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.918
ALA11
3.500
VAL12
3.219
GLY13
3.406
VAL14
3.303
GLY15
2.874
LYS16
2.558
SER17
2.935
ALA18
2.907
LEU19
4.763
PHE28
3.347
VAL29
2.708
ASP30
2.549
GLU31
3.731
TYR32
2.591
ASP33
4.404
|
|||||
| PDB ID: 1K8R Crystal structure of Ras-Bry2RBD complex | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [53] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:119 or .A:120 or .A:144 or .A:145 or .A:146 or .A:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
4.039
GLY12
3.937
GLY13
3.003
VAL14
3.316
GLY15
3.052
LYS16
2.868
SER17
2.505
ALA18
2.676
LEU19
4.837
PHE28
3.238
VAL29
2.710
ASP30
3.411
GLU31
3.326
TYR32
3.337
ASP33
4.322
|
|||||
| PDB ID: 4G3X Crystal Structure of Q61L H-Ras-GppNHp bound to the RBD of Raf Kinase | ||||||
| Method | X-ray diffraction | Resolution | 3.25 Å | Mutation | Yes | [49] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 LEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:117 or .A:119 or .A:120 or .A:145 or .A:146 or .A:147; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY10
4.783
ALA11
2.971
GLY12
3.814
GLY13
3.368
VAL14
2.972
GLY15
3.666
LYS16
2.304
SER17
2.497
ALA18
3.752
PHE28
3.871
VAL29
3.514
ASP30
3.214
GLU31
4.652
TYR32
3.195
|
|||||
| PDB ID: 4NYM Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | ||||||
| Method | X-ray diffraction | Resolution | 3.55 Å | Mutation | Yes | [22] |
| PDB Sequence |
MTEYKLVVVG
10 AGGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEASAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHQYREQI100 KRVKDSDDVP 110 MVLVGNKCDL120 AARTVESRQA130 QDLARSYGIP140 YIETSAKTRQ150 GVEDAFYTLV 160 REIRQH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .Q:11 or .Q:12 or .Q:13 or .Q:14 or .Q:15 or .Q:16 or .Q:17 or .Q:18 or .Q:28 or .Q:29 or .Q:30 or .Q:31 or .Q:32 or .Q:33 or .Q:34 or .Q:35 or .Q:57 or .Q:58 or .Q:59 or .Q:60 or .Q:61 or .Q:116 or .Q:117 or .Q:118 or .Q:119 or .Q:120 or .Q:144 or .Q:145 or .Q:146 or .Q:147; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA11
4.503
GLY12
4.115
GLY13
2.948
VAL14
3.797
GLY15
2.918
LYS16
2.695
SER17
2.422
ALA18
2.942
PHE28
3.628
VAL29
2.956
ASP30
2.761
GLU31
4.100
TYR32
3.421
ASP33
4.141
PRO34
3.292
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| References | Top | ||||
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| REF 1 | Structural basis for intramolecular interaction of post-translationally modified H-Ras?GTP prepared by protein ligation. FEBS Lett. 2017 Aug;591(16):2470-2481. | ||||
| REF 2 | Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers. J Biol Chem. 2011 Nov 11;286(45):39644-53. | ||||
| REF 3 | In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. | ||||
| REF 4 | Structural basis for conformational dynamics of GTP-bound Ras protein. J Biol Chem. 2010 Jul 16;285(29):22696-705. | ||||
| REF 5 | Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein. Biochem Biophys Res Commun. 2021 Aug 6;565:85-90. | ||||
| REF 6 | Molecular Mechanism for Conformational Dynamics of Ras GTP Elucidated from In-Situ Structural Transition in Crystal. Sci Rep. 2016 May 16;6:25931. | ||||
| REF 7 | Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants. FEBS Lett. 2012 Jun 12;586(12):1715-8. | ||||
| REF 8 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. | ||||
| REF 9 | Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chem Biol. 2017 Dec 21;24(12):1455-1466.e14. | ||||
| REF 10 | Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J Biol Chem. 2020 Apr 3;295(14):4526-4540. | ||||
| REF 11 | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife. 2017 Jul 7;6:e27810. | ||||
| REF 12 | Structural insights into Ras regulation by SIN1. Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2119990119. | ||||
| REF 13 | Evolution of AF6-RAS association and its implications in mixed-lineage leukemia. Nat Commun. 2017 Oct 23;8(1):1099. | ||||
| REF 14 | Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J Med Chem. 2020 Aug 13;63(15):8325-8337. | ||||
| REF 15 | Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61(19):8875-8894. | ||||
| REF 16 | Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS. ACS Med Chem Lett. 2018 Aug 8;9(9):941-946. | ||||
| REF 17 | Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling. J Med Chem. 2018 Jul 26;61(14):6002-6017. | ||||
| REF 18 | Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods | ||||
| REF 19 | Crystal structure of the GppNHp-bound form of the RasG60A mutant | ||||
| REF 20 | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal Biochem. 2018 May 1;548:44-52. | ||||
| REF 21 | Structural basis for the interaction of Ras with RalGDS. Nat Struct Biol. 1998 Jun;5(6):422-6. | ||||
| REF 22 | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6. | ||||
| REF 23 | Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring. Biochemistry. 2018 Sep 11;57(36):5350-5358. | ||||
| REF 24 | The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. Structure. 1999 Nov 15;7(11):1311-24. | ||||
| REF 25 | Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4931-6. | ||||
| REF 26 | Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase. J Biol Chem. 2011 Feb 4;286(5):3323-31. | ||||
| REF 27 | Accessing protein conformational ensembles using room-temperature X-ray crystallography. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16247-52. | ||||
| REF 28 | Shift in the equilibrium between on and off states of the allosteric switch in Ras-GppNHp affected by small molecules and bulk solvent composition. Biochemistry. 2012 Aug 7;51(31):6114-26. | ||||
| REF 29 | Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. Structure. 2007 Dec;15(12):1618-29. | ||||
| REF 30 | Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO J. 1990 Aug;9(8):2351-9. | ||||
| REF 31 | A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet. 2010 Jan;42(1):27-9. | ||||
| REF 32 | Analysis of binding site hot spots on the surface of Ras GTPase. J Mol Biol. 2011 Nov 4;413(4):773-89. | ||||
| REF 33 | Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. Angew Chem Int Ed Engl. 2010 May 17;49(22):3830-3. | ||||
| REF 34 | Structure of a transient intermediate for GTP hydrolysis by ras. Structure. 2006 Mar;14(3):427-36. | ||||
| REF 35 | Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry. 1993 Aug 24;32(33):8411-20. | ||||
| REF 36 | The structural basis for the transition from Ras-GTP to Ras-GDP. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12138-42. | ||||
| REF 37 | Equilibria between conformational states of the Ras oncogene protein revealed by high pressure crystallography. Chem Sci. 2022 Jan 13;13(7):2001-2010. | ||||
| REF 38 | Regulation of GTPase function by autophosphorylation. Mol Cell. 2022 Mar 3;82(5):950-968.e14. | ||||
| REF 39 | A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction. Biophys J. 2006 Aug 1;91(3):981-92. | ||||
| REF 40 | Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. EMBO J. 2008 Jul 23;27(14):1995-2005. | ||||
| REF 41 | Allosteric modulation of H-Ras GTPase | ||||
| REF 42 | Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. FASEB J. 2015 Sep;29(9):3750-61. | ||||
| REF 43 | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep. 2019 Aug 6;28(6):1538-1550.e7. | ||||
| REF 44 | Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP Gamma-Phosphate. J Biol Chem. 2015 Dec 25;290(52):31025-36. | ||||
| REF 45 | Organic solvents order the dynamic switch II in Ras crystals. Structure. 2003 Jul;11(7):747-51. | ||||
| REF 46 | Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell. 1990 Aug 10;62(3):539-48. | ||||
| REF 47 | Exceptionally high-affinity Ras binders that remodel its effector domain. J Biol Chem. 2018 Mar 2;293(9):3265-3280. | ||||
| REF 48 | Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell. 2003 Mar 7;112(5):685-95. | ||||
| REF 49 | Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD. Structure. 2015 Mar 3;23(3):505-516. | ||||
| REF 50 | Crystal Structure Reveals the Full Ras-Raf Interface and Advances Mechanistic Understanding of Raf Activation. Biomolecules. 2021 Jul 7;11(7):996. | ||||
| REF 51 | Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):4944-9. | ||||
| REF 52 | Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell. 2000 Dec 8;103(6):931-43. | ||||
| REF 53 | The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure. 2001 Nov;9(11):1043-50. | ||||
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