Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T74456 | Target Info | |||
| Target Name | Angiotensin II receptor type-1 (AGTR1) | ||||
| Synonyms | Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; Angiotensin II receptor 1; Angiotensin 1 receptor; AT2R1B; AT2R1; AT1BR; AT1AR; AT1; AGTR1B; AGTR1A | ||||
| Target Type | Successful Target | ||||
| Gene Name | AGTR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Sarcosine | Ligand Info | |||
| Canonical SMILES | CNCC(=O)O | ||||
| InChI | 1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) | ||||
| InChIKey | FSYKKLYZXJSNPZ-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 1088 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6OS2 Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV026 | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
IKRIQDDCPK
20 AGRHNYIFVM30 IPTLYSIIFV40 VGIFGNSLVV50 IVIYFYMKLK60 TVASVFLLNL 70 ALADLCFLLT80 LPLWAVYTAM90 EYRWPFGNYL100 CKIASASVSF110 NLYASVFLLT 120 CLSIDRYLAI130 VHPMKSRLRR140 TMLVAKVTCI150 IIWLLAGLAS160 LPAIIHRNVF 170 FIENTNITVC180 AFHYESQNST190 LPIGLGLTKN200 ILGFLFPFLI210 ILTSYTLIWK 220 ALKKAYDLED230 NWETLNDNLK240 VIEKADNAAQ250 VKDALTKMRA260 AALDAQKAHG 289 FDILVGQIDD299 ALKLANEGKV309 KEAQAAAEQL319 KKNKPRNDDI1238 FKIIMAIVLF 1248 FFFSWIPHQI1258 FTFLDVLIQL1268 GIIRDCRIAD1278 IVDTAMPITI1288 CIAYFNNCLN 1298 PLFYGFLGKK1308 FKRYFLQLLK1318
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| PDB ID: 6OS1 Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV023 | ||||||
| Method | X-ray diffraction | Resolution | 2.79 Å | Mutation | Yes | [1] |
| PDB Sequence |
IKRIQDDCPK
20 AGRHNYIFVM30 IPTLYSIIFV40 VGIFGNSLVV50 IVIYFYMKLK60 TVASVFLLNL 70 ALADLCFLLT80 LPLWAVYTAM90 EYRWPFGNYL100 CKIASASVSF110 NLYASVFLLT 120 CLSIDRYLAI130 VHPMKSRLRR140 TMLVAKVTCI150 IIWLLAGLAS160 LPAIIHRNVF 170 FIENTNITVC180 AFHYESQNST190 LPIGLGLTKN200 ILGFLFPFLI210 ILTSYTLIWK 220 ALKKAYDLED230 NWETLNDNLK240 VIEKADNAAQ250 VKDALTKMRA260 AALDAQKARH 288 GFDILVGQID298 DALKLANEGK308 VKEAQAAAEQ318 LKKNKPRNDD1237 IFKIIMAIVL 1247 FFFFSWIPHQ1257 IFTFLDVLIQ1267 LGIIRDCRIA1277 DIVDTAMPIT1287 ICIAYFNNCL 1297 NPLFYGFLGK1307 KFKRYFLQLL1317 K
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science. 2020 Feb 21;367(6480):888-892. | ||||
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