Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83904 | Target Info | |||
| Target Name | NAD-dependent deacetylase sirtuin-2 (SIRT2) | ||||
| Synonyms | SIR2like protein 2; SIR2L2; SIR2L; SIR2-like protein 2; Regulatory protein SIR2 homolog 2; NADdependent protein deacetylase sirtuin2; NAD-dependent protein deacetylase sirtuin-2 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | SIRT2 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Nicotinamide | Ligand Info | |||
| Canonical SMILES | C1=CC(=CN=C1)C(=O)N | ||||
| InChI | 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | ||||
| InChIKey | DFPAKSUCGFBDDF-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 936 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4RMJ Human Sirt2 in complex with ADP ribose and nicotinamide | ||||||
| Method | X-ray diffraction | Resolution | 1.87 Å | Mutation | No | [1] |
| PDB Sequence |
MERLLDELTL
64 EGVARYMQSE74 RCRRVICLVG84 AGISTSAGIP94 DFRSPSTGLY104 DNLEKYHLPY 114 PEAIFEISYF124 KKHPEPFFAL134 AKELYPGQFK144 PTICHYFMRL154 LKDKGLLLRC 164 YTQNIDTLER174 IAGLEQEDLV184 EAHGTFYTSH194 CVSASCRHEY204 PLSWMKEKIF 214 SEVTPKCEDC224 QSLVKPDIVF234 FGESLPARFF244 SCMQSDFLKV254 DLLLVMGTSL 264 QVQPFASLIS274 KAPLSTPRLL284 INKEKAGQSD294 PFLGMIMGLG304 GGMDFDSKKA 314 YRDVAWLGEC324 DQGCLALAEL334 LGWKKELEDL344 VRREHASIDA354 Q |
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| PDB ID: 6L71 Sirtuin 2 demyristoylation native intermediate I & II mixture | ||||||
| Method | X-ray diffraction | Resolution | 2.11 Å | Mutation | No | [2] |
| PDB Sequence |
SQKERLLDEL
62 TLEGVARYMQ72 SERCRRVICL82 VGAGISTSAG92 IPDFRSPSTG102 LYDNLEKYHL 112 PYPEAIFEIS122 YFKKHPEPFF132 ALAKELYPGQ142 FKPTICHYFM152 RLLKDKGLLL 162 RCYTQNIDTL172 ERIAGLEQED182 LVEAHGTFYT192 SHCVSASCRH202 EYPLSWMKEK 212 IFSEVTPKCE222 DCQSLVKPDI232 VFFGESLPAR242 FFSCMQSDFL252 KVDLLLVMGT 262 SLQVQPFASL272 ISKAPLSTPR282 LLINKEKAGQ292 SDPFLGGMDF309 DSKKAYRDVA 319 WLGECDQGCL329 ALAELLGWKK339 ELEDLVRREH349 ASIDAQ
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015 Feb 12;6:6263. | ||||
| REF 2 | Sirtuin 2 protein with H3K18 myristoylated peptide | ||||
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