Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84133 | Target Info | |||
| Target Name | Phosphodiesterase 10A (PDE10) | ||||
| Synonyms | cAMP and cAMPinhibited cGMP 3',5'cyclic phosphodiesterase 10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PDE10A | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | S,S-(2-Hydroxyethyl)Thiocysteine | Ligand Info | |||
| Canonical SMILES | C(CSSCC(C(=O)O)N)O | ||||
| InChI | 1S/C5H11NO3S2/c6-4(5(8)9)3-11-10-2-1-7/h4,7H,1-3,6H2,(H,8,9)/t4-/m0/s1 | ||||
| InChIKey | YPUBRSXDQSFQBA-BYPYZUCNSA-N | ||||
| PubChem Compound ID | 170018 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5SI1 Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-4-(morpholine-4-carbonyl)-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3-carboxamide, space group I23 | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [1] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETA
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| PDB ID: 5SIM Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-4-(2-methylpyrrolidine-1-carbonyl)-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [2] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETA
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| PDB ID: 5SIS Crystal Structure of human phosphodiesterase 10 in complex with 4-N,2-dimethyl-4-N-[2-(methylamino)ethyl]-3-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [3] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETATW
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| PDB ID: 5SFE Crystal Structure of human phosphodiesterase 10 in complex with 3-N-[2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-4-N,4-N,2-trimethylpyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | No | [4] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SGW Crystal Structure of human phosphodiesterase 10 in complex with 2-phenyl-6-(2-phenylpyrazol-3-yl)-3,4-dihydropyridazin-5-one | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [5] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SHO Crystal Structure of human phosphodiesterase 10 in complex with 4-N-cyclopropyl-2-methyl-3-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [6] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEETA
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SIH Crystal Structure of human phosphodiesterase 10 in complex with 6-(3-methylphenyl)sulfanyl-2-(4-pyridin-2-ylpiperazin-1-yl)-9H-purine | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [7] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SKN Crystal Structure of human phosphodiesterase 10 in complex with N-[3-[3-[2-(2-fluorophenyl)pyrazol-3-yl]-4-oxopyridazin-1-yl]phenyl]acetamide | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [8] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SKM Crystal Structure of human phosphodiesterase 10 in complex with 6-chloro-N,N-dimethyl-2-[2-(1-pyridin-2-ylpyrrolidin-3-yl)ethyl]quinazolin-4-amine | ||||||
| Method | X-ray diffraction | Resolution | 1.91 Å | Mutation | No | [9] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SGX Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-[2-methyl-5-[(2R)-2-(trifluoromethyl)pyrrolidin-1-yl]-1,2,4-triazol-3-yl]ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine | ||||||
| Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | No | [10] |
| PDB Sequence |
> Chain A
GLMQFTLPVR 467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE> Chain B QGLMQFTLPV 466 RLKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EET
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .B:462 or .B:464 or .B:465 or .B:466 or .B:467 or .B:468 or .B:470 or .B:471 or .B:472 or .B:473 or .B:487 or .B:488 or .B:491 or .B:492 or .B:505 or .B:506 or .B:507 or .B:508 or .B:510 or .B:511 or .B:512 or .B:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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PHE462[A]
4.658
PRO487[A]
4.017
VAL491[A]
3.904
GLU504[A]
4.923
LEU505[A]
2.943
GLU506[A]
3.546
LYS507[A]
3.297
LEU508[A]
1.311
ARG510[A]
1.327
PHE511[A]
3.318
ILE512[A]
3.559
MET513[A]
3.165
PHE462[B]
3.911
LEU464[B]
4.070
PRO465[B]
2.871
VAL466[B]
3.136
ARG467[B]
3.423
LEU468[B]
1.334
LYS470[B]
1.337
GLU471[B]
3.509
ILE472[B]
3.471
GLU473[B]
4.025
PRO487[B]
4.051
GLY488[B]
4.286
VAL491[B]
3.709
TYR492[B]
3.907
LEU505[B]
2.969
GLU506[B]
3.414
LYS507[B]
3.334
LEU508[B]
1.330
ARG510[B]
1.321
PHE511[B]
3.396
ILE512[B]
3.400
MET513[B]
3.072
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| PDB ID: 5SE9 Crystal Structure of human phosphodiesterase 10 in complex with 2,3-dimethyl-6-[(1-methyl-4-phenylimidazol-2-yl)methoxy]imidazo[1,2-b]pyridazine | ||||||
| Method | X-ray diffraction | Resolution | 1.94 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SJV Crystal Structure of human phosphodiesterase 10 in complex with 5-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]quinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 1.94 Å | Mutation | No | [12] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 5SE6 Crystal Structure of human phosphodiesterase 10 in complex with 2,9-dimethyl-6-[(1-methyl-4-phenylimidazol-2-yl)methoxy]purine | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 5SGP Crystal Structure of human phosphodiesterase 10 in complex with 4-N-(2-methoxyethyl)-4-N,2-dimethyl-3-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [13] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 5SHB Crystal Structure of human phosphodiesterase 10 in complex with 3-[2-(3-bromophenyl)pyrazol-3-yl]-1-pyridin-4-ylpyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [14] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SHV Crystal Structure of human phosphodiesterase 10 in complex with 1-(6-fluoropyridin-2-yl)piperidin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [15] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SJW Crystal Structure of human phosphodiesterase 10 in complex with 4-chloro-2-(2-methylpropyl)-N-(2-phenyl-1H-benzimidazol-5-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [16] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SK5 Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-4-(morpholine-4-carbonyl)-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3-carboxamide, space group H3 | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [17] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SFO Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SG6 Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | No | [18] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SGH Crystal Structure of human phosphodiesterase 10 in complex with 4-[1-methyl-6-[(1-methyl-4-phenylimidazol-2-yl)methoxy]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine | ||||||
| Method | X-ray diffraction | Resolution | 1.97 Å | Mutation | No | [19] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SGI Crystal Structure of human phosphodiesterase 10 in complex with 6-(3-methylphenoxy)-2-(4-pyridin-2-ylpiperazin-1-yl)-9H-purine | ||||||
| Method | X-ray diffraction | Resolution | 1.97 Å | Mutation | No | [20] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SIQ Crystal Structure of human phosphodiesterase 10 in complex with 2-ethyl-3-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]quinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 1.97 Å | Mutation | No | [21] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJG Crystal Structure of human phosphodiesterase 10 in complex with 1-[2-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)ethyl]-1-methylimidazol-4-yl]pyrrolidin-2-one | ||||||
| Method | X-ray diffraction | Resolution | 1.97 Å | Mutation | No | [22] |
| PDB Sequence |
> Chain A
LMQFTLPVRL 468 KEIELFHFDI479 GPFENMWPGI489 FVYMVHRSCG499 TSCFELEKLR510 FIMSVKKNYR 520 RVPYHNWKHA530 VTVAHCMYAI540 LQNNHTLFTD550 LERKGLLIAC560 LCHDLDHRGF 570 SNSYLQKFDH580 PLAALYSTST590 MEQHHFSQTV600 SILQLEGHNI610 FSTLSSSEYE 620 QVLEIIRKAI630 IATDLALYFG640 NRKQLEEMYQ650 TGSLNLNNQS660 HRDRVIGLMM 670 TACDLCSVTK680 LWPVTKLTAN690 DIYAEFWAEG700 DEMKKLGIQP710 IPMMDRDKKD 720 EVPQGQLGFY730 NAVAIPCYTT740 LTQILPPTEP750 LLKACRDNLS760 QWEKVIRGEE 770 > Chain B QGLMQFTLPV 466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEET
|
|||||
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:464 or .A:465 or .A:466 or .A:467 or .A:468 or .A:470 or .A:471 or .A:472 or .A:473 or .A:487 or .A:488 or .A:491 or .A:492 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .B:462 or .B:487 or .B:488 or .B:491 or .B:505 or .B:506 or .B:507 or .B:508 or .B:510 or .B:511 or .B:512 or .B:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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PHE462[A]
3.653
LEU464[A]
3.738
PRO465[A]
2.805
VAL466[A]
3.269
ARG467[A]
3.390
LEU468[A]
1.328
LYS470[A]
1.328
GLU471[A]
3.657
ILE472[A]
3.362
GLU473[A]
3.931
PRO487[A]
4.058
GLY488[A]
4.177
VAL491[A]
3.948
TYR492[A]
3.511
LEU505[A]
2.839
GLU506[A]
3.583
LYS507[A]
3.444
LEU508[A]
1.321
ARG510[A]
1.339
PHE511[A]
3.308
ILE512[A]
3.364
MET513[A]
3.092
PHE462[B]
3.793
PRO487[B]
3.968
GLY488[B]
4.250
VAL491[B]
3.993
LEU505[B]
2.999
GLU506[B]
3.445
LYS507[B]
3.393
LEU508[B]
1.330
ARG510[B]
1.327
PHE511[B]
3.432
ILE512[B]
3.546
MET513[B]
3.080
|
|||||
| PDB ID: 5SJU Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[4-(piperidin-1-ylmethyl)-1,3-thiazol-2-yl]-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.97 Å | Mutation | No | [23] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETATWI
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SF5 Crystal Structure of human phosphodiesterase 10 in complex with 2,3-dimethyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]imidazo[1,2-b]pyridazine | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFB Crystal Structure of human phosphodiesterase 10 in complex with N,2,3-trimethyl-6-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]imidazo[1,2-b]pyridazine-8-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SG3 Crystal Structure of human phosphodiesterase 10 in complex with N-[(E)-(4-bromo-3,5-dimethoxyphenyl)methylideneamino]-2-ethoxy-2-(4-morpholin-4-ylphenyl)acetamide | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [24] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SH3 Crystal Structure of human phosphodiesterase 10 in complex with 2,3-dimethyl-6-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-8-methylsulfonylimidazo[1,2-b]pyridazine | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [25] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SH6 Crystal Structure of human phosphodiesterase 10 in complex with 4-[2-(1-methylbenzimidazol-2-yl)ethyl]-2,3-dihydro-1,4-benzoxazepin-5-one | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [26] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHR Crystal Structure of human phosphodiesterase 10 in complex with N-[(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl]-N,2-dimethyl-5-phenyl-1,2,4-triazol-3-amine | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [27] |
| PDB Sequence |
> Chain A
LMQFTLPVRL 468 KEIELFHFDI479 GPFENMWPGI489 FVYMVHRSCG499 TSCFELEKLR510 FIMSVKKNYR 520 RVPYHNWKHA530 VTVAHCMYAI540 LQNNHTLFTD550 LERKGLLIAC560 LCHDLDHRGF 570 SNSYLQKFDH580 PLAALYSTST590 MEQHHFSQTV600 SILQLEGHNI610 FSTLSSSEYE 620 QVLEIIRKAI630 IATDLALYFG640 NRKQLEEMYQ650 TGSLNLNNQS660 HRDRVIGLMM 670 TACDLCSVTK680 LWPVTKLTAN690 DIYAEFWAEG700 DEMKKLGIQP710 IPMMDRDKKD 720 EVPQGQLGFY730 NAVAIPCYTT740 LTQILPPTEP750 LLKACRDNLS760 QWEKVIRGEE 770 > Chain B QGLMQFTLPV 466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEET
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:464 or .A:465 or .A:466 or .A:467 or .A:468 or .A:470 or .A:471 or .A:472 or .A:473 or .A:487 or .A:488 or .A:491 or .A:492 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .B:462 or .B:487 or .B:488 or .B:491 or .B:505 or .B:506 or .B:507 or .B:508 or .B:510 or .B:511 or .B:512 or .B:513 or .B:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PHE462[A]
3.632
LEU464[A]
3.835
PRO465[A]
2.744
VAL466[A]
3.083
ARG467[A]
3.372
LEU468[A]
1.328
LYS470[A]
1.339
GLU471[A]
3.682
ILE472[A]
3.399
GLU473[A]
3.974
PRO487[A]
4.082
GLY488[A]
4.260
VAL491[A]
4.148
TYR492[A]
3.607
GLU504[A]
4.944
LEU505[A]
2.782
GLU506[A]
3.659
LYS507[A]
3.390
LEU508[A]
1.324
ARG510[A]
1.320
PHE511[A]
3.295
ILE512[A]
3.434
MET513[A]
3.213
PHE462[B]
3.757
PRO487[B]
3.937
GLY488[B]
4.532
VAL491[B]
3.689
LEU505[B]
3.035
GLU506[B]
3.301
LYS507[B]
3.266
LEU508[B]
1.335
ARG510[B]
1.305
PHE511[B]
3.311
ILE512[B]
3.395
MET513[B]
3.086
SER514[B]
4.998
|
|||||
| PDB ID: 5SHU Crystal Structure of human phosphodiesterase 10 in complex with 2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-3,5,6,7-tetrahydropyrrolo[3,2-f]benzimidazole | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [28] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SID Crystal Structure of human phosphodiesterase 10 in complex with 5-chloro-2-[2-(6,8-dichloro-5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)ethyl]-1,3-benzothiazole | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [29] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJI Crystal Structure of human phosphodiesterase 10 in complex with 4-chloro-2-methyl-N-(2-phenyl-1H-benzimidazol-5-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [30] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SE8 Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-[2-(2-methyl-5-phenyl-1,2,4-triazol-3-yl)ethyl]pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEX Crystal Structure of human phosphodiesterase 10 in complex with N-methyl-6-[(6-methylpyridine-2-carbonyl)amino]-2-phenyl-3H-benzimidazole-5-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEZ Crystal Structure of human phosphodiesterase 10 in complex with 2-chloro-6-ethyl-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-4-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIT Crystal Structure of human phosphodiesterase 10 in complex with 6-methyl-N-(4-methylphenyl)pyrimidin-4-amine | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [31] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJ2 Crystal Structure of human phosphodiesterase 10 in complex with 2,3-dichloro-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-4-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [32] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKR Crystal Structure of human phosphodiesterase 10 in complex with 1-methyl-N-(2-methyl-5-pyridin-2-ylpyrazol-3-yl)-4-pyridin-4-ylpyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [33] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEA Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-(2-phenylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFP Crystal Structure of human phosphodiesterase 10 in complex with N-(2-chloropyridin-4-yl)-2-phenylpyrazolo[1,5-a]pyridine-6-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGV Crystal Structure of human phosphodiesterase 10 in complex with 1-benzyl-3-(2-phenylpyrazol-3-yl)pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [34] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SH8 Crystal Structure of human phosphodiesterase 10 in complex with 6-methyl-N-(5-methyl-2-phenylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [35] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHK Crystal Structure of human phosphodiesterase 10 in complex with N-(6-methylpyridin-2-yl)-5-pyridin-3-yl-1,7-naphthyridin-8-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [36] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SI6 Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-N-(6-cyano-2-phenylimidazo[1,2-a]pyridin-7-yl)-2-methylpyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [37] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SK4 Crystal Structure of human phosphodiesterase 10 in complex with 6-methyl-3-(2-phenylpyrazol-3-yl)-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [38] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKP Crystal Structure of human phosphodiesterase 10 in complex with [4-(2-methoxyphenyl)piperazin-1-yl]-(3-methyl-1-phenylthieno[2,3-c]pyrazol-5-yl)methanone | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [39] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKQ Crystal Structure of human phosphodiesterase 10 in complex with N-ethyl-6-(4-fluorophenyl)sulfanyl-N-methyl-9H-purin-2-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [40] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SE0 Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[2-(2-hydroxyethyl)-5-pyridin-2-ylpyrazol-3-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFI Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-[2-methyl-5-(2-methylpyrrolidin-1-yl)-1,2,4-triazol-3-yl]ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SI9 Crystal Structure of human phosphodiesterase 10 in complex with 4-N-(2-hydroxyethyl)-2-methyl-3-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [41] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIU Crystal Structure of human phosphodiesterase 10 in complex with 3-[2-(6,8-dichloro-5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)ethyl]-1H-quinoxalin-2-one | ||||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [42] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SF2 Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-(3-oxo-1,2-dihydroisoindol-5-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.02 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETATW
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:464 or .A:465 or .A:466 or .A:467 or .A:468 or .A:470 or .A:471 or .A:472 or .A:473 or .A:487 or .A:488 or .A:491 or .A:492 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PHE462
4.177
LEU464
3.829
PRO465
2.894
VAL466
3.293
ARG467
3.406
LEU468
1.333
LYS470
1.337
GLU471
3.603
ILE472
3.482
GLU473
4.043
PRO487
4.263
GLY488
4.625
|
|||||
| PDB ID: 5SFN Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-[2-(1-methylbenzimidazol-2-yl)ethyl]pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.02 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SK0 Crystal Structure of human phosphodiesterase 10 in complex with N-[(3R)-1-(5-chloropyridin-2-yl)pyrrolidin-3-yl]-1-methyl-4-pyridin-4-ylpyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.02 Å | Mutation | No | [43] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKT Crystal Structure of human phosphodiesterase 10 in complex with 7-(cyclopropylmethoxy)-2-methyl-4-pyrrolidin-1-ylquinazoline:hydrochloride | ||||||
| Method | X-ray diffraction | Resolution | 2.02 Å | Mutation | No | [44] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEC Crystal Structure of human phosphodiesterase 10 in complex with 2-[2-(1,4-diphenylimidazol-2-yl)ethyl]-3-methylquinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SF6 Crystal Structure of human phosphodiesterase 10 in complex with 6,7-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-N-propan-2-ylimidazo[2,1-f][1,2,4]triazin-4-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGS Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-3-[2-(1-pyridin-2-ylpyrrolidin-3-yl)ethyl]quinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [45] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHN Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-4-N-(1,3-oxazol-2-ylmethyl)-3-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [46] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIG Crystal Structure of human phosphodiesterase 10 in complex with 1-[(4-methoxyphenyl)methyl]-1-[(4-oxo-3H-quinazolin-2-yl)methyl]-3-phenylurea | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [47] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIP Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [48] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIY Crystal Structure of human phosphodiesterase 10 in complex with 5-[(3R)-3-fluoropyrrolidin-1-yl]-N-methyl-2-(3-methylquinoxalin-2-yl)-N-(oxan-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [49] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKG Crystal Structure of human phosphodiesterase 10 in complex with 2-chloro-6-(cyclopropylamino)-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-4-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [50] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEN Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(1-quinolin-2-ylimidazol-4-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFR Crystal Structure of human phosphodiesterase 10 in complex with 4-N-ethyl-3-N-[2-[3-(2-fluoroethoxy)phenyl]imidazo[1,2-a]pyrimidin-7-yl]-4-N,2-dimethylpyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFX Crystal Structure of human phosphodiesterase 10 in complex with N-(2-acetamido-1,3-benzothiazol-5-yl)-4-(azetidine-1-carbonyl)-2-methylpyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGQ Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-3-(pyrimidin-5-ylamino)pyrazine-2-carboxylic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | No | [51] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGR Crystal Structure of human phosphodiesterase 10 in complex with 2-chloro-3-[(1-methyl-4-phenylimidazol-2-yl)methoxy]quinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | No | [52] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFD Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-(2-methyl-5-piperidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJF Crystal Structure of human phosphodiesterase 10 in complex with 3-(2-quinolin-4-ylpyrazol-3-yl)-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [53] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJN Crystal Structure of human phosphodiesterase 10 in complex with 6,8-dichloro-2-[2-(6,7-dimethyl-1H-benzimidazol-2-yl)ethyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyridine | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [54] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SG0 Crystal Structure of human phosphodiesterase 10 in complex with 1-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]-3-(2-phenylpyrazol-3-yl)imidazolidin-2-one | ||||||
| Method | X-ray diffraction | Resolution | 2.06 Å | Mutation | No | [55] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SH9 Crystal Structure of human phosphodiesterase 10 in complex with 2-[2-[5-[(3R)-3-fluoropyrrolidin-1-yl]-2-methyl-1,2,4-triazol-3-yl]ethyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.06 Å | Mutation | No | [56] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJX Crystal Structure of human phosphodiesterase 10 in complex with 2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline | ||||||
| Method | X-ray diffraction | Resolution | 2.06 Å | Mutation | No | [57] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGN Crystal Structure of human phosphodiesterase 10 in complex with 2,3-dimethyl-6-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-7-(trifluoromethyl)imidazo[1,2-b]pyridazine | ||||||
| Method | X-ray diffraction | Resolution | 2.07 Å | Mutation | No | [58] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SE5 Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[1-methyl-5-(methylcarbamoyl)pyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SF7 Crystal Structure of human phosphodiesterase 10 in complex with 1-(2-chlorophenyl)-8-methoxy-3,4-dimethylimidazo[1,5-a]quinazolin-5-one | ||||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFY Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[(E)-2-[2-methyl-5-(1H-pyrazol-4-yl)-1,2,4-triazol-3-yl]ethenyl]-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHQ Crystal Structure of human phosphodiesterase 10 in complex with 4-pyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine | ||||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [59] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJC Crystal Structure of human phosphodiesterase 10 in complex with 4-chloro-2,5-dimethyl-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [60] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETA
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEU Crystal Structure of human phosphodiesterase 10 in complex with 2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-6-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridine | ||||||
| Method | X-ray diffraction | Resolution | 2.09 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGC Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.09 Å | Mutation | No | [61] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGG Crystal Structure of human phosphodiesterase 10 in complex with 2-[(4-chloro-3,5-dimethylpyridin-2-yl)methylsulfanyl]-6,7-dihydro-3H-furo[3,2-f]benzimidazole | ||||||
| Method | X-ray diffraction | Resolution | 2.09 Å | Mutation | No | [62] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEH Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEM Crystal Structure of human phosphodiesterase 10 in complex with 3-methyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-2-(trifluoromethyl)imidazo[1,2-b]pyridazine | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEO Crystal Structure of human phosphodiesterase 10 in complex with 2-[2-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethyl]isoindole-1,3-dione | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEP Crystal Structure of human phosphodiesterase 10 in complex with 2-[2-(4-cyclopentyl-1-methylimidazol-2-yl)ethyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SF0 Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(3-pyridin-2-yl-1H-pyrazol-5-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHI Crystal Structure of human phosphodiesterase 10 in complex with 2,3,5-trimethyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]imidazo[1,2-a]pyridine | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [63] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SI7 Crystal Structure of human phosphodiesterase 10 in complex with 2-benzyl-6,6-dimethyl-1H-imidazo[4,5-h]isoquinoline-7,9-dione | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [64] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SI8 Crystal Structure of human phosphodiesterase 10 in complex with N-(6-cyano-2-phenylimidazo[1,2-a]pyridin-7-yl)-1-methyl-4-(morpholine-4-carbonyl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [65] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SIK Crystal Structure of human phosphodiesterase 10 in complex with 5-(cyclopentylmethoxy)pyrimidin-2-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [66] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SIZ Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-3-methoxy-N-[2-(3-pyridin-3-yl-1H-1,2,4-triazol-5-yl)ethyl]pyrazine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [67] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SJ3 Crystal Structure of human phosphodiesterase 10 in complex with [1-(4-chlorophenyl)-3-methylthieno[2,3-c]pyrazol-5-yl]-piperidin-1-ylmethanone | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [68] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SJE Crystal Structure of human phosphodiesterase 10 in complex with 3-[2-(2,2-difluoro-1,3-benzodioxol-4-yl)pyrazol-3-yl]-1-(3-methylsulfonylphenyl)pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [69] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJJ Crystal Structure of human phosphodiesterase 10 in complex with 4-N-ethyl-5-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [70] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJO Crystal Structure of human phosphodiesterase 10 in complex with 3-[2-(2,4-difluorophenyl)pyrazol-3-yl]-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [71] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJR Crystal Structure of human phosphodiesterase 10 in complex with (2R)-2-[[3-cyano-2-[4-(2-ethoxyphenyl)phenyl]-6-fluoroquinolin-4-yl]amino]propanoic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [72] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJT Crystal Structure of human phosphodiesterase 10 in complex with 4-N,4-N,2-trimethyl-3-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [73] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKF Crystal Structure of human phosphodiesterase 10 in complex with 3-[5-[1-(2,2-difluoro-1,3-benzodioxol-4-yl)-4-oxopyridazin-3-yl]pyrazol-1-yl]benzonitrile | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [74] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKH Crystal Structure of human phosphodiesterase 10 in complex with 3-[2-(3-fluorophenyl)pyrazol-3-yl]-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [75] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKO Crystal Structure of human phosphodiesterase 10 in complex with N-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-1-methyl-3-(pyrimidin-5-ylamino)pyrazole-4-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [76] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SES Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(2-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.11 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SF1 Crystal Structure of human phosphodiesterase 10 in complex with 2-(difluoromethyl)-3-methyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethynyl]imidazo[1,2-b]pyridazine | ||||||
| Method | X-ray diffraction | Resolution | 2.11 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHG Crystal Structure of human phosphodiesterase 10 in complex with 3-(2-chlorophenyl)-12-methoxy-5-methyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-7-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | No | [77] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIE Crystal Structure of human phosphodiesterase 10 in complex with 5-chloro-8-hydroxy-2-methyl-1,4-dihydropyrrolo[3,4-b]indol-3-one | ||||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | No | [78] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJQ Crystal Structure of human phosphodiesterase 10 in complex with 6-chloro-2,3-dimethylquinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | No | [79] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SFL Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[5-[(2-hydroxy-2-methylpropyl)carbamoyl]-1-methylpyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.13 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 5SG9 Crystal Structure of human phosphodiesterase 10 in complex with 2-[(E)-2-(4-methyl-6-pyrrolidin-1-ylpyrimidin-2-yl)ethenyl]quinoline | ||||||
| Method | X-ray diffraction | Resolution | 2.13 Å | Mutation | No | [80] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGK Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-[(7R)-2-(2-methylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-yl]pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.13 Å | Mutation | No | [81] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SIW 5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-8-(trifluoromethyl)-[1,2,4]triazolo[1,5-c]pyrimidine | ||||||
| Method | X-ray diffraction | Resolution | 2.13 Å | Mutation | No | [82] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJA Crystal Structure of human phosphodiesterase 10 in complex with N-(2-tert-butyl-5-methylpyrazol-3-yl)-1-phenyl-3-(pyridin-2-yloxymethyl)thieno[2,3-c]pyrazole-5-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.13 Å | Mutation | No | [83] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SE3 Crystal Structure of human phosphodiesterase 10 in complex with 2-chloro-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-4-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.14 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGU Crystal Structure of human phosphodiesterase 10 in complex with 12-methoxy-5,7-dimethyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaene | ||||||
| Method | X-ray diffraction | Resolution | 2.14 Å | Mutation | No | [84] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETAT
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJ7 Crystal Structure of human phosphodiesterase 10 in complex with 7-[(5-methyl-4-propan-2-yloxypyridin-2-yl)methylsulfanyl]-6H-imidazo[4,5-g][1,3]benzothiazole | ||||||
| Method | X-ray diffraction | Resolution | 2.14 Å | Mutation | No | [85] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SK2 Crystal Structure of human phosphodiesterase 10 in complex with 2-(4-fluorophenyl)-4-(2-isoquinolin-3-yloxyethyl)-5-methyl-1,3-oxazole | ||||||
| Method | X-ray diffraction | Resolution | 2.14 Å | Mutation | No | [86] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SDU Crystal Structure of human phosphodiesterase 10 in complex with 5-methyl-4-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-2-phenyl-1,3-oxazole | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SDV Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-4-N-(1,3-oxazol-4-ylmethyl)-3-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [11] |
| PDB Sequence |
MQFTLPVRLC
469 KEIELFHFDI479 GPFENMWPGI489 FVYMVHRSCG499 TSCFELEKLR510 FIMSVKKNYR 520 RVPYHNWKHA530 VTVAHCMYAI540 LQNNHTLFTD550 LERKGLLIAC560 LCHDLDHRGF 570 SNSYLQKFDH580 PLAALYSTST590 MEQHHFSQTV600 SILQLEGHNI610 FSTLSSSEYE 620 QVLEIIRKAI630 IATDLALYFG640 NRKQLEEMYQ650 TGSLNLNNQS660 HRDRVIGLMM 670 TACDLCSVTK680 LWPVTKLTAN690 DIYAEFWAEG700 DEMKKLGIQP710 IPMMDRDKKD 720 EVPQGQLGFY730 NAVAIPCYTT740 LTQILPPTEP750 LLKACRDNLS760 QWEKVIRGEE 770
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEK Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-3-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]quinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SF3 Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-3-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-4-N-(1H-pyrazol-5-ylmethyl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SF8 Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-[2-(5-phenyl-2-pyridin-2-yl-1,2,4-triazol-3-yl)ethyl]pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFW Crystal Structure of human phosphodiesterase 10 in complex with 5-ethyl-8-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SG2 Crystal Structure of human phosphodiesterase 10 in complex with 3-methylimidazo[4,5-f]quinolin-2-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [87] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SHH Crystal Structure of human phosphodiesterase 10 in complex with 7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-6H-imidazo[4,5-g][1,3]benzothiazole | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [88] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJ6 Crystal Structure of human phosphodiesterase 10 in complex with 4-(2-chloroquinazolin-4-yl)morpholine | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [89] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETA
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKK Crystal Structure of human phosphodiesterase 10 in complex with N-[1-methyl-5-(methylcarbamoyl)pyrazol-4-yl]-6-[(3S)-oxolan-3-yl]-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [90] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFF Crystal Structure of human phosphodiesterase 10 in complex with [2-methyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethynyl]imidazo[1,2-b]pyridazin-3-yl]methanol | ||||||
| Method | X-ray diffraction | Resolution | 2.16 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFM Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-4-(morpholine-4-carbonyl)-N-(2-phenyl-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.16 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFZ Crystal Structure of human phosphodiesterase 10 in complex with 1-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]-3-(2-phenylpyrazol-3-yl)urea | ||||||
| Method | X-ray diffraction | Resolution | 2.16 Å | Mutation | No | [91] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SG8 Crystal Structure of human phosphodiesterase 10 in complex with 5-butoxy-4-ethoxypyrimidin-2-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.16 Å | Mutation | No | [92] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHX Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-3-pyrrolidin-1-ylquinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 2.16 Å | Mutation | No | [93] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJ1 Crystal Structure of human phosphodiesterase 10 in complex with 7-[(3,5-dimethyl-4-propan-2-yloxypyridin-2-yl)methylsulfinyl]-6H-imidazo[4,5-g][1,3]benzothiazole | ||||||
| Method | X-ray diffraction | Resolution | 2.16 Å | Mutation | No | [94] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJD Crystal Structure of human phosphodiesterase 10 in complex with 1-[2-(3,5-dimethylpyrazol-1-yl)ethyl]-3-(2-phenylpyrazol-3-yl)urea | ||||||
| Method | X-ray diffraction | Resolution | 2.16 Å | Mutation | No | [95] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKI Crystal Structure of human phosphodiesterase 10 in complex with N-[(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl]-2-methyl-5-phenyl-1,2,4-triazol-3-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.16 Å | Mutation | No | [96] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SE7 Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.17 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SG5 Crystal Structure of human phosphodiesterase 10 in complex with 1-[(4-methoxyphenyl)methyl]-3-(4-methylphenyl)-1-[(4-oxo-3H-quinazolin-2-yl)methyl]urea | ||||||
| Method | X-ray diffraction | Resolution | 2.17 Å | Mutation | No | [97] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEQ Crystal Structure of human phosphodiesterase 10 in complex with 5,6,8-trimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.18 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFC Crystal Structure of human phosphodiesterase 10 in complex with | ||||||
| Method | X-ray diffraction | Resolution | 2.18 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHP Crystal Structure of human phosphodiesterase 10 in complex with 2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-3H-imidazo[4,5-h]quinoline | ||||||
| Method | X-ray diffraction | Resolution | 2.18 Å | Mutation | No | [98] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SII Crystal Structure of human phosphodiesterase 10 in complex with 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine | ||||||
| Method | X-ray diffraction | Resolution | 2.18 Å | Mutation | No | [99] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETA
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SDX Crystal Structure of human phosphodiesterase 10 in complex with 4-[6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]pyridin-2-yl]morpholine | ||||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SH2 Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(2-morpholin-4-yl-1,3-benzothiazol-5-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [100] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHE Crystal Structure of human phosphodiesterase 10 in complex with 2,3-dimethylquinoxalin-6-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [101] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHW Crystal Structure of human phosphodiesterase 10 in complex with (2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)methanol | ||||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [102] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJZ Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-4-(morpholine-4-carbonyl)-N-(2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [103] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SDY Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[5-(dimethylcarbamoyl)-1-(2-methoxyethyl)pyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETAT
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SE2 Crystal Structure of human phosphodiesterase 10 in complex with 2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]quinoline | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEL Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-(2-methyl-5-pyridin-2-ylpyrazol-3-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGE Crystal Structure of human phosphodiesterase 10 in complex with 6H-imidazo[1,2-c]quinazolin-5-one | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [104] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGM Crystal Structure of human phosphodiesterase 10 in complex with 3-N-[2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]-4-N,4-N,2-trimethylpyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [105] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETA
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGZ Crystal Structure of human phosphodiesterase 10 in complex with 3-(2-chlorophenyl)-12-methoxy-5-methyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-7-one | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [106] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SH1 Crystal Structure of human phosphodiesterase 10 in complex with 5-methyl-2-phenyl-4-(2-quinolin-8-yloxyethyl)-1,3-oxazole | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [107] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIF Crystal Structure of human phosphodiesterase 10 in complex with 3-[2-(2,5-difluorophenyl)pyrazol-3-yl]-1-(3-methylsulfonylphenyl)pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [108] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIO Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-4-(2-methylpyrrolidine-1-carbonyl)-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [109] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIV Crystal Structure of human phosphodiesterase 10 in complex with N-(thiophen-2-ylmethyl)quinoxaline-6-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [110] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SJB Crystal Structure of human phosphodiesterase 10 in complex with 2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-3H-imidazo[4,5-f]quinoline | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [111] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SJY Crystal Structure of human phosphodiesterase 10 in complex with 4-bromo-2,5-dimethyl-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [112] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SK6 Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-N-[3-(1,3-benzoxazol-2-yl)phenyl]-2-methylpyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [113] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SKE Crystal Structure of human phosphodiesterase 10 in complex with 2-tert-butyl-5-(pyrimidin-5-ylamino)-N-[3-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [114] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKL Crystal Structure of human phosphodiesterase 10 in complex with N-(6-cyano-2-phenylimidazo[1,2-a]pyridin-7-yl)-2-methyl-4-(morpholine-4-carbonyl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [115] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SKU Crystal Structure of human phosphodiesterase 10 in complex with 3-[4-[2-[2-(2-ethoxy-4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]naphthalen-1-yl]-2-methoxypropanoic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [116] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFQ Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-N-[1-(2,2-difluoroethyl)pyrazol-3-yl]-2-methylpyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.21 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKA Crystal Structure of human phosphodiesterase 10 in complex with 7-[(4-ethoxy-5-methylpyridin-2-yl)methylsulfanyl]-6H-imidazo[4,5-g][1,3]benzothiazole | ||||||
| Method | X-ray diffraction | Resolution | 2.21 Å | Mutation | No | [117] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SH4 Crystal Structure of human phosphodiesterase 10 in complex with 6-[(5-methoxy-3,4,6-trimethylpyridin-2-yl)methylsulfanyl]-5H-[1,3]dioxolo[4,5-f]benzimidazole | ||||||
| Method | X-ray diffraction | Resolution | 2.22 Å | Mutation | No | [118] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFS Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-[2-methyl-5-[(3S)-3-methylpyrrolidin-1-yl]-1,2,4-triazol-3-yl]ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.24 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHA Crystal Structure of human phosphodiesterase 10 in complex with 2-[2-[5-[3-(difluoromethyl)pyrrolidin-1-yl]-2-methyl-1,2,4-triazol-3-yl]ethyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.24 Å | Mutation | No | [119] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJK Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dichloro-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one | ||||||
| Method | X-ray diffraction | Resolution | 2.24 Å | Mutation | No | [120] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SER Crystal Structure of human phosphodiesterase 10 in complex with 4-N-(2-fluoroethyl)-4-N,2-dimethyl-3-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.25 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SF4 Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[2-[2-(dimethylamino)ethyl]-5-pyridin-2-ylpyrazol-3-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.25 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJP Crystal Structure of human phosphodiesterase 10 in complex with ethyl N-[[4-[[4-(azetidine-1-carbonyl)-2-methylpyrazole-3-carbonyl]amino]-6-methylpyridin-2-yl]carbamothioyl]carbamate | ||||||
| Method | X-ray diffraction | Resolution | 2.25 Å | Mutation | No | [121] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGT Crystal Structure of human phosphodiesterase 10 in complex with 2-[2-[3-(4-methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]isoindole-1,3-dione | ||||||
| Method | X-ray diffraction | Resolution | 2.26 Å | Mutation | No | [122] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SHM Crystal Structure of human phosphodiesterase 10 in complex with N-[(3R)-1-(5-chloropyridin-2-yl)pyrrolidin-3-yl]-6-cyclopropyl-3-methoxypyrazine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.26 Å | Mutation | No | [123] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SHT Crystal Structure of human phosphodiesterase 10 in complex with 8-chloro-5,7-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine | ||||||
| Method | X-ray diffraction | Resolution | 2.27 Å | Mutation | No | [124] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SI0 Crystal Structure of human phosphodiesterase 10 in complex with 7-methyl-2,5-bis[2-(1-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine | ||||||
| Method | X-ray diffraction | Resolution | 2.27 Å | Mutation | No | [125] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SI5 Crystal Structure of human phosphodiesterase 10 in complex with N-(12-methoxy-5-methyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaen-7-yl)methanesulfonamide | ||||||
| Method | X-ray diffraction | Resolution | 2.27 Å | Mutation | No | [126] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SIA Crystal Structure of human phosphodiesterase 10 in complex with 1-(2,3-dimethylquinoxalin-6-yl)-3-(3-methoxyphenyl)urea | ||||||
| Method | X-ray diffraction | Resolution | 2.27 Å | Mutation | No | [127] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SEB Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-3-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]quinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 2.28 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SGL Crystal Structure of human phosphodiesterase 10 in complex with N-[(E)-(4-bromo-3,5-dimethoxyphenyl)methylideneamino]-2-ethoxy-2-(4-pyrazol-1-ylphenyl)acetamide | ||||||
| Method | X-ray diffraction | Resolution | 2.28 Å | Mutation | No | [128] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETATW
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SHF Crystal Structure of human phosphodiesterase 10 in complex with 3,6-dimethyl-N-(2-phenylpyrazolo[1,5-a]pyridin-6-yl)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.28 Å | Mutation | No | [129] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEF Crystal Structure of human phosphodiesterase 10 in complex with 5,7,8-trimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine | ||||||
| Method | X-ray diffraction | Resolution | 2.29 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EET
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEG Crystal Structure of human phosphodiesterase 10 in complex with 6-[(5-bromo-1-methyl-2-oxopyridine-3-carbonyl)amino]-N-(oxetan-3-yl)-2-phenyl-3H-benzimidazole-5-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.29 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEY Crystal Structure of human phosphodiesterase 10 in complex with [2-cyclopropyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethynyl]imidazo[1,2-b]pyridazin-3-yl]methanol | ||||||
| Method | X-ray diffraction | Resolution | 2.29 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFH Crystal Structure of human phosphodiesterase 10 in complex with N-cyclopropyl-5-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-N,1-dimethyl-1,2,4-triazol-3-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.29 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SH0 Crystal Structure of human phosphodiesterase 10 in complex with N-(1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-[methylsulfonyl(naphthalen-1-yl)amino]acetamide | ||||||
| Method | X-ray diffraction | Resolution | 2.29 Å | Mutation | No | [130] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIX Crystal Structure of human phosphodiesterase 10 in complex with 5-[(3R)-3-fluoropyrrolidin-1-yl]-2-(3-methylquinoxalin-2-yl)-N-(oxan-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.29 Å | Mutation | No | [131] |
| PDB Sequence |
QGLMQFTLPV
466 RLKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETA
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:464 or .A:465 or .A:466 or .A:467 or .A:468 or .A:470 or .A:471 or .A:472 or .A:473 or .A:487 or .A:488 or .A:491 or .A:492 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PHE462
4.393
LEU464
3.922
PRO465
2.903
VAL466
3.214
ARG467
3.376
LEU468
1.333
LYS470
1.337
GLU471
3.570
ILE472
3.618
GLU473
4.101
PRO487
4.093
|
|||||
| PDB ID: 5SK7 Crystal Structure of human phosphodiesterase 10 in complex with 7-bromo-N,N-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.29 Å | Mutation | No | [132] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SE1 Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[3-(dimethylcarbamoyl)-1-methylpyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETAT
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SEW Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[1-(2-methoxyethyl)-5-(methylcarbamoyl)pyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [11] |
| PDB Sequence |
QGLMQFTLPV
466 RLKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETA
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:464 or .A:465 or .A:466 or .A:467 or .A:468 or .A:470 or .A:471 or .A:472 or .A:473 or .A:487 or .A:488 or .A:491 or .A:492 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PHE462
3.550
LEU464
3.801
PRO465
2.898
VAL466
3.222
ARG467
3.382
LEU468
1.333
LYS470
1.328
GLU471
3.549
ILE472
3.415
GLU473
4.084
PRO487
4.407
|
|||||
| PDB ID: 5SG4 Crystal Structure of human phosphodiesterase 10 in complex with 3-N-[2-(3-chlorophenyl)-1H-benzimidazol-5-yl]-2-methylpyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [133] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETAT
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGF Crystal Structure of human phosphodiesterase 10 in complex with ethyl 1-methyl-5-(propylcarbamoyl)pyrazole-4-carboxylate | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [134] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SH5 Crystal Structure of human phosphodiesterase 10 in complex with 2-amino-4-cyclohexyloxyquinoline-3-carbonitrile | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [135] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHJ Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-N-[3-(phenylcarbamoyl)phenyl]pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [136] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHS Crystal Structure of human phosphodiesterase 10 in complex with 3-(naphthalen-1-ylmethyl)-7-piperidin-1-yltriazolo[4,5-d]pyrimidine | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [137] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHY Crystal Structure of human phosphodiesterase 10 in complex with [8-[(2-methyl-1,3-thiazol-4-yl)amino]-5-pyridin-3-yl-1,7-naphthyridin-2-yl]methanol | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [138] |
| PDB Sequence |
QGLMQFTLPV
466 RLCKEIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJM Crystal Structure of human phosphodiesterase 10 in complex with 3-(2-phenylethyl)-5-pyridin-4-yl-1H-pyridin-2-one | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [139] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SK1 Crystal Structure of human phosphodiesterase 10 in complex with 4-N,2-dimethyl-3-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [140] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SK8 Crystal Structure of human phosphodiesterase 10 in complex with 4-chloro-N-(2-phenyl-1H-benzimidazol-5-yl)-2-propylpyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [141] |
| PDB Sequence |
GLMQFTLPVR
467 LKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETA
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:464 or .A:465 or .A:466 or .A:467 or .A:468 or .A:470 or .A:471 or .A:472 or .A:473 or .A:487 or .A:488 or .A:491 or .A:492 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PHE462
3.968
LEU464
3.865
PRO465
2.900
VAL466
3.367
ARG467
3.394
LEU468
1.329
LYS470
1.337
GLU471
3.587
ILE472
3.477
GLU473
4.047
PRO487
4.363
|
|||||
| PDB ID: 5SKD Crystal Structure of human phosphodiesterase 10 in complex with 3-[2-(2,5-difluorophenyl)pyrazol-3-yl]-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [142] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEV Crystal Structure of human phosphodiesterase 10 in complex with 2,3,5-trimethyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.31 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFG Crystal Structure of human phosphodiesterase 10 in complex with N-[(3R)-1-(5-chloropyridin-2-yl)pyrrolidin-3-yl]-6-cyclopropyl-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.31 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKS Crystal Structure of human phosphodiesterase 10 in complex with ethyl 1-[3-[3-(4-ethoxycarbonyl-5-methyl-imidazol-1-yl)phenoxy]phenyl]-5-methyl-imidazole-4-carboxylate | ||||||
| Method | X-ray diffraction | Resolution | 2.31 Å | Mutation | No | [143] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SED Crystal Structure of human phosphodiesterase 10 in complex with 4-[6-chloro-2-[(1-methyl-4-phenylimidazol-2-yl)methoxy]quinazolin-4-yl]morpholine | ||||||
| Method | X-ray diffraction | Resolution | 2.32 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFA Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-3-[(1-methyl-4-phenylimidazol-2-yl)methoxy]-N-(oxolan-3-yl)pyrazine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.32 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFT Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-(1-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.32 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SK3 Crystal Structure of human phosphodiesterase 10 in complex with [2-cyclopropyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]imidazo[1,2-b]pyridazin-3-yl]methanol | ||||||
| Method | X-ray diffraction | Resolution | 2.32 Å | Mutation | No | [144] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFK Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-3-(pyrimidin-5-ylamino)-N-[1-(2,2,2-trifluoroethyl)pyrazol-3-yl]pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.33 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHC Crystal Structure of human phosphodiesterase 10 in complex with 1-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]-2-oxo-N-pyrimidin-5-ylpyridine-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.33 Å | Mutation | No | [145] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SDW Crystal Structure of human phosphodiesterase 10 in complex with 4-N,4-N,2-trimethyl-3-N-(2-phenyl-1H-benzimidazol-5-yl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SDZ Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[3-[2,3-dihydroxypropyl(methyl)carbamoyl]-1-methylpyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEE Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-(2-pyridin-2-ylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SHL Crystal Structure of human phosphodiesterase 10 in complex with 6-chloro-2,3-dimethyl-8-pyrrolidin-1-ylimidazo[1,2-b]pyridazine | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [146] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJ0 Crystal Structure of human phosphodiesterase 10 in complex with N-cyclohexyl-N-methyl-9H-purin-6-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [147] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKB Crystal Structure of human phosphodiesterase 10 in complex with 9-methoxy-3,5-dihydropyrimido[5,4-b]indol-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [148] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGY Crystal Structure of human phosphodiesterase 10 in complex with 4-chloro-2-(2-methylpropyl)-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.36 Å | Mutation | No | [149] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEI Crystal Structure of human phosphodiesterase 10 in complex with 6-chloro-2-[(E)-2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethenyl]-[1,2,4]triazolo[1,5-a]pyridine | ||||||
| Method | X-ray diffraction | Resolution | 2.37 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SF9 Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-3-[(1-methyl-4-phenylimidazol-2-yl)methoxy]quinoxaline | ||||||
| Method | X-ray diffraction | Resolution | 2.37 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGB Crystal Structure of human phosphodiesterase 10 in complex with 5-(4-chloronaphthalen-1-yl)oxythiadiazole | ||||||
| Method | X-ray diffraction | Resolution | 2.39 Å | Mutation | No | [150] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SI4 Crystal Structure of human phosphodiesterase 10 in complex with 3-(2-naphthalen-1-ylpyrazol-3-yl)-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.39 Å | Mutation | No | [151] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJ9 Crystal Structure of human phosphodiesterase 10 in complex with N-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridine-8-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.39 Å | Mutation | No | [152] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SET Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-(2-methyl-5-pyridin-2-ylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETA
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SFU Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-3-(pyrimidin-5-ylamino)-N-[4-(pyrrolidine-1-carbonyl)pyridin-3-yl]pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SI2 Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-(1-pyridin-2-ylpyrrolidin-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [153] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SI3 Crystal Structure of human phosphodiesterase 10 in complex with 1-methyl-5-[(2-phenylimidazo[1,2-a]pyrimidin-7-yl)carbamoyl]pyrazole-4-carboxylic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [154] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EET
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIN Crystal Structure of human phosphodiesterase 10 in complex with N-(3-methyl-1-pyridin-2-ylthieno[2,3-c]pyrazol-5-yl)benzamide | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [155] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFJ Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-3-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-4-N-(pyridin-2-ylmethyl)pyrazole-3,4-dicarboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.41 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SFV Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-N-(1-cyclopentylpyrazol-3-yl)-2-methylpyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.41 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SG1 Crystal Structure of human phosphodiesterase 10 in complex with 2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]quinoline | ||||||
| Method | X-ray diffraction | Resolution | 2.41 Å | Mutation | No | [156] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SEJ Crystal Structure of human phosphodiesterase 10 in complex with 6-chloro-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyridine | ||||||
| Method | X-ray diffraction | Resolution | 2.44 Å | Mutation | No | [11] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJ5 Crystal Structure of human phosphodiesterase 10 in complex with 6-chloroquinoxalin-2-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.49 Å | Mutation | No | [157] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJ8 Crystal Structure of human phosphodiesterase 10 in complex with 12-methoxy-5-methyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaene-7-carbonitrile | ||||||
| Method | X-ray diffraction | Resolution | 2.49 Å | Mutation | No | [158] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SE4 Crystal Structure of human phosphodiesterase 10 in complex with 5-cyclopropyl-7-methyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidine | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [11] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIL Crystal Structure of human phosphodiesterase 10 in complex with 4-chloro-N-[2-(3,5-dimethylphenyl)-1H-benzimidazol-5-yl]-2-methylpyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [159] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 ETA
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIR Crystal Structure of human phosphodiesterase 10 in complex with 3,6-dimethyl-N-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [160] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGD Crystal Structure of human phosphodiesterase 10 in complex with 4-(methoxymethyl)-2-methyl-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazole-3-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.54 Å | Mutation | No | [161] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SIB Crystal Structure of human phosphodiesterase 10 in complex with 3-methyl-6-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-2-(trifluoromethyl)imidazo[1,2-b]pyridazine | ||||||
| Method | X-ray diffraction | Resolution | 2.54 Å | Mutation | No | [162] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5SHZ Crystal Structure of human phosphodiesterase 10 in complex with 3-[2-(3-ethynylphenyl)pyrazol-3-yl]-1-phenylpyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.55 Å | Mutation | No | [163] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EETA
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SIJ Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | ||||||
| Method | X-ray diffraction | Resolution | 2.55 Å | Mutation | No | [164] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
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|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SHD Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[4-(methylcarbamoyl)pyridin-3-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [165] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SKC Crystal Structure of human phosphodiesterase 10 in complex with 6-methyl-N-(1-propan-2-ylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [166] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SKV Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[3-[(2-hydroxy-2-methylpropyl)carbamoyl]-1-methylpyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [167] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJL Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[4-[(2-hydroxy-2-methylpropyl)carbamoyl]pyridin-3-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.64 Å | Mutation | No | [168] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SGJ Crystal Structure of human phosphodiesterase 10 in complex with 6-[(3,6-dimethylpyridine-2-carbonyl)amino]-N-methyl-2-phenyl-3H-benzimidazole-5-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.66 Å | Mutation | No | [169] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 5SH7 Crystal Structure of human phosphodiesterase 10 in complex with 6-[(5-cyclopropyl-2-oxo-1H-pyridine-3-carbonyl)amino]-N-(oxetan-3-yl)-2-phenyl-3H-benzimidazole-5-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.66 Å | Mutation | No | [170] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJS Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[4-(dimethylcarbamoyl)pyridin-3-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [171] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SKJ Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[2-[2-(methylamino)-2-oxoethyl]phenyl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | ||||||
| Method | X-ray diffraction | Resolution | 2.74 Å | Mutation | No | [172] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5SJ4 Crystal Structure of human phosphodiesterase 10 in complex with 1-methyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.77 Å | Mutation | No | [173] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:491 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5EDI human PDE10A, 6-Chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20A, H3, Rfree=23.5% | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [174] |
| PDB Sequence |
> Chain A
GLMQFTLPVR 467 LCREIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE> Chain B TSEEWQGLMQ 461 FTLPVRLCRE471 IELFHFDIGP481 FENMWPGIFV491 YMVHRSCGTS501 CFELEKLRFI 512 MSVKKNYRRV522 PYHNWKHAVT532 VAHCMYAILQ542 NNHTLFTDLE552 RKGLLIACLC 562 HDLDHRGFSN572 SYLQKFDHPL582 AALYSTSTME592 QHHFSQTVSI602 LQLEGHNIFS 612 TLSSSEYEQV622 LEIIRKAIIA632 TDLALYFGNR642 KQLEEMYQTG652 SLNLNNQSHR 662 DRVIGLMMTA672 CDLCSVTKLW682 PVTKLTANDI692 YAEFWAEGDE702 MKKLGIQPIP 712 MMDRDKKDEV722 PQGQLGFYNA732 VAIPCYTTLT742 QILPPTEPLL752 KACRDNLSQW 762 EKVIRGEEA
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .B:462 or .B:487 or .B:488 or .B:491 or .B:505 or .B:506 or .B:507 or .B:508 or .B:510 or .B:511 or .B:512 or .B:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PHE462[A]
3.950
PRO487[A]
3.779
GLY488[A]
3.737
VAL491[A]
3.815
GLU504[A]
4.988
LEU505[A]
2.942
GLU506[A]
3.556
LYS507[A]
3.313
LEU508[A]
1.335
ARG510[A]
1.328
PHE511[A]
3.251
ILE512[A]
3.426
MET513[A]
2.977
|
|||||
| PDB ID: 5I2R human PDE10A in complex with 3-(2-phenylpyrazol-3-yl)-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [174] |
| PDB Sequence |
GLMQFTLPVR
467 LCKEIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5EDH human PDE10A, 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine, 2.03A, H3, Rfree=22.7% | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [174] |
| PDB Sequence |
LMQFTLPVRL
468 CKEIELFHFD478 IGPFENMWPG488 IFVYMVHRSC498 GTSCFELEKL508 RFIMSVKKNY 519 RRVPYHNWKH529 AVTVAHCMYA539 ILQNNHTLFT549 DLERKGLLIA559 CLCHDLDHRG 569 FSNSYLQKFD579 HPLAALYSTS589 TMEQHHFSQT599 VSILQLEGHN609 IFSTLSSSEY 619 EQVLEIIRKA629 IIATDLALYF639 GNRKQLEEMY649 QTGSLNLNNQ659 SHRDRVIGLM 669 MTACDLCSVT679 KLWPVTKLTA689 NDIYAEFWAE699 GDEMKKLGIQ709 PIPMMDRDKK 719 DEVPQGQLGF729 YNAVAIPCYT739 TLTQILPPTE749 PLLKACRDNL759 SQWEKVIRGE 769 E
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 5EDE human PDE10A in complex with 1-(4-Chloro-phenyl)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2A | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [174] |
| PDB Sequence |
> Chain A
QGLMQFTLPV 466 RLCREIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEE> Chain B AGLMQFTLPV 466 RLCREIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEEA
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .A:514 or .B:462 or .B:487 or .B:488 or .B:491 or .B:504 or .B:505 or .B:506 or .B:507 or .B:508 or .B:510 or .B:511 or .B:512 or .B:513 or .B:514; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PHE462[A]
3.834
PRO487[A]
3.752
GLY488[A]
3.758
VAL491[A]
4.101
GLU504[A]
4.803
LEU505[A]
2.874
GLU506[A]
3.596
LYS507[A]
3.281
LEU508[A]
1.309
ARG510[A]
1.302
PHE511[A]
3.227
ILE512[A]
3.473
MET513[A]
2.967
SER514[A]
4.980
|
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| PDB ID: 5EDG human PDE10A in complex with 3-(2-Chloro-5-phenyl-3H-imidazol-4-yl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one at 2.30A | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [174] |
| PDB Sequence |
> Chain A
GLMQFTLPVR 467 LCREIELFHF477 DIGPFENMWP487 GIFVYMVHRS497 CGTSCFELEK507 LRFIMSVKKN 518 YRRVPYHNWK528 HAVTVAHCMY538 AILQNNHTLF548 TDLERKGLLI558 ACLCHDLDHR 568 GFSNSYLQKF578 DHPLAALYST588 STMEQHHFSQ598 TVSILQLEGH608 NIFSTLSSSE 618 YEQVLEIIRK628 AIIATDLALY638 FGNRKQLEEM648 YQTGSLNLNN658 QSHRDRVIGL 668 MMTACDLCSV678 TKLWPVTKLT688 ANDIYAEFWA698 EGDEMKKLGI708 QPIPMMDRDK 718 KDEVPQGQLG728 FYNAVAIPCY738 TTLTQILPPT748 EPLLKACRDN758 LSQWEKVIRG 768 EE> Chain B QGLMQFTLPV 466 RLCREIELFH476 FDIGPFENMW486 PGIFVYMVHR496 SCGTSCFELE506 KLRFIMSVKK 517 NYRRVPYHNW527 KHAVTVAHCM537 YAILQNNHTL547 FTDLERKGLL557 IACLCHDLDH 567 RGFSNSYLQK577 FDHPLAALYS587 TSTMEQHHFS597 QTVSILQLEG607 HNIFSTLSSS 617 EYEQVLEIIR627 KAIIATDLAL637 YFGNRKQLEE647 MYQTGSLNLN657 NQSHRDRVIG 667 LMMTACDLCS677 VTKLWPVTKL687 TANDIYAEFW697 AEGDEMKKLG707 IQPIPMMDRD 717 KKDEVPQGQL727 GFYNAVAIPC737 YTTLTQILPP747 TEPLLKACRD757 NLSQWEKVIR 767 GEEA
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CME or .CME2 or .CME3 or :3CME;style chemicals stick;color identity;select .A:462 or .A:484 or .A:487 or .A:488 or .A:491 or .A:504 or .A:505 or .A:506 or .A:507 or .A:508 or .A:510 or .A:511 or .A:512 or .A:513 or .B:462 or .B:487 or .B:491 or .B:505 or .B:506 or .B:507 or .B:508 or .B:510 or .B:511 or .B:512 or .B:513; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PHE462[A]
3.959
ASN484[A]
4.964
PRO487[A]
4.051
GLY488[A]
4.203
VAL491[A]
4.127
GLU504[A]
4.974
LEU505[A]
2.916
GLU506[A]
3.901
LYS507[A]
3.469
LEU508[A]
1.330
ARG510[A]
1.324
PHE511[A]
3.384
ILE512[A]
3.638
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 2 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 3 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 4 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 5 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 6 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 7 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 8 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 9 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 10 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 11 | A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios. J Comput Aided Mol Des. 2022 Oct;36(10):753-765. | ||||
| REF 12 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 13 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
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| REF 172 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 173 | Crystal Structure of a human phosphodiesterase 10 complex | ||||
| REF 174 | A Real-World Perspective on Molecular Design. J Med Chem. 2016 May 12;59(9):4087-102. | ||||
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