Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T89458 | Target Info | |||
| Target Name | HepG2 glucose transporter (SLC2A1) | ||||
| Synonyms | Solute carrier family 2, facilitated glucose transporter member 1; HepG2 glucosetransporter; Glucose transporter type 1, erythrocyte/brain; GLUT1; GLUT-1 | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | SLC2A1 | ||||
| Biochemical Class | Major facilitator | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | B-Nonylglucoside | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCOC1C(C(C(C(O1)CO)O)O)O | ||||
| InChI | 1S/C15H30O6/c1-2-3-4-5-6-7-8-9-20-15-14(19)13(18)12(17)11(10-16)21-15/h11-19H,2-10H2,1H3/t11-,12-,13+,14-,15-/m1/s1 | ||||
| InChIKey | QFAPUKLCALRPLH-UXXRCYHCSA-N | ||||
| PubChem Compound ID | 155448 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6THA Crystal structure of human sugar transporter GLUT1 (SLC2A1) in the inward conformation | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
LTGRLMLAVG
17 GAVLGSLQFG27 YNTGVINAPQ37 KVIEEFYNQT47 WVHRYGESIL57 PTTLTTLWSL 67 SVAIFSVGGM77 IGSFSVGLFV87 NRFGRRNSML97 MMNLLAFVSA107 VLMGFSKLGK 117 SFEMLILGRF127 IIGVYCGLTT137 GFVPMYVGEV147 SPTALRGALG157 TLHQLGIVVG 167 ILIAQVFGLD177 SIMGNKDLWP187 LLLSIIFIPA197 LLQCIVLPFC207 PESPRFLLIN 217 RNEENRAKSV227 LKKLRGTADV237 THDLQEMKEE247 SRQMMREKKV257 TILELFRSPA 267 YRQPILIAVV277 LQLSQQLSGI287 NAVFYYSTSI297 FEKAGVQQPV307 YATIGSGIVN 317 TAFTVVSLFV327 VERAGRRTLH337 LIGLAGMAGC347 AILMTIALAL357 LEQLPWMSYL 367 SIVAIFGFVA377 FFEVGPGPIP387 WFIVAELFSQ397 GPRPAAIAVA407 GFSNWTSNFI 417 VGMCFQYVEQ427 LCGPYVFIIF437 TVLLVLFFIF447 TYFKVPET
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THR30
3.546
ARG93
3.152
ASN94
3.162
LEU97
4.234
MET98
4.160
PRO141
3.821
GLY157
4.438
HIS160
4.032
GLN161
3.295
ILE164
4.681
VAL165
3.720
ILE168
3.738
GLU209
2.574
LEU214
4.590
ARG218
2.773
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| PDB ID: 4PYP Crystal structure of the human glucose transporter GLUT1 | ||||||
| Method | X-ray diffraction | Resolution | 3.17 Å | Mutation | Yes | [2] |
| PDB Sequence |
TGRLMLAVGG
18 AVLGSLQFGY28 NTGVINAPQK38 VIEEFYTQTW48 VHRYGESILP58 TTLTTLWSLS 68 VAIFSVGGMI78 GSFSVGLFVN88 RFGRRNSMLM98 MNLLAFVSAV108 LMGFSKLGKS 118 FEMLILGRFI128 IGVYCGLTTG138 FVPMYVGEVS148 PTALRGALGT158 LHQLGIVVGI 168 LIAQVFGLDS178 IMGNKDLWPL188 LLSIIFIPAL198 LQCIVLPFCP208 ESPRFLLINR 218 NEENRAKSVL228 KKLRGTADVT238 HDLQEMKEES248 RQMMREKKVT258 ILELFRSPAY 268 RQPILIAVVL278 QLSQQLSGIN288 AVFYYSTSIF298 EKAGVQQPVY308 ATIGSGIVNT 318 AFTVVSLFVV328 QRAGRRTLHL338 IGLAGMAGCA348 ILMTIALALL358 EQLPWMSYLS 368 IVAIFGFVAF378 FEVGPGPIPW388 FIVAELFSQG398 PRPAAIAVAG408 FSNWTSNFIV 418 GMCFQYVEQL428 CGPYVFIIFT438 VLLVLFFIFT448 YFKVPET
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family. Life Sci Alliance. 2021 Feb 3;4(4):e202000858. | ||||
| REF 2 | Crystal structure of the human glucose transporter GLUT1. Nature. 2014 Jun 5;510(7503):121-5. | ||||
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