Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T95553 | Target Info | |||
Target Name | ADP-ribosylation factor-like protein 2 (ARL2) | ||||
Synonyms | ARFL2 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | ARL2 | ||||
Biochemical Class | Small GTPase | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | Guanosine-5'-Triphosphate | Ligand Info | |||
Canonical SMILES | C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N | ||||
InChI | 1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1 | ||||
InChIKey | XKMLYUALXHKNFT-UUOKFMHZSA-N | ||||
PubChem Compound ID | 135398633 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 3DOE Complex of ARL2 and BART, Crystal Form 1 | ||||||
Method | X-ray diffraction | Resolution | 2.25 Å | Mutation | No | [1] |
PDB Sequence |
GLLTILKKMK
11 QKERELRLLM21 LGLDNAGKTT31 ILKKFNGEDI41 DTISPTLGFN51 IKTLEHRGFK 61 LNIWDVGGQK71 SLRSYWRNYF81 ESTDGLIWVV91 DSADRQRMQD101 CQRELQSLLV 111 EERLAGATLL121 IFANKQDLPG131 ALSSNAIREV141 LELDSIRSHH151 WCIQGCSAVT 161 GENLLPGIDW171 LLDDISSRIF181 TADLEHHHH
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GLY23
4.815
LEU24
3.626
ASP25
3.475
ASN26
3.142
ALA27
3.216
GLY28
2.766
LYS29
2.630
THR30
2.925
THR31
2.715
ILE44
3.535
SER45
4.399
PRO46
3.514
THR47
2.579
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PDB ID: 3DOF Complex of ARL2 and BART, Crystal Form 2 | ||||||
Method | X-ray diffraction | Resolution | 3.30 Å | Mutation | No | [1] |
PDB Sequence |
GLLTILKKMK
11 QKERELRLLM21 LGLDNAGKTT31 ILKKFNGEDI41 DTISPTLGFN51 IKTLEHRGFK 61 LNIWDVGGQK71 SLRSYWRNYF81 ESTDGLIWVV91 DSADRQRMQD101 CQRELQSLLV 111 EERLAGATLL121 IFANKQDLPG131 ALSSNAIREV141 LELDSIRSHH151 WCIQGCSAVT 161 GENLLPGIDW171 LLDDISSRIF181 TADLEHHHH
|
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GLY23
4.588
LEU24
3.653
ASP25
3.318
ASN26
2.965
ALA27
3.160
GLY28
2.995
LYS29
2.844
THR30
3.023
THR31
2.614
ILE44
3.510
SER45
4.493
PRO46
3.717
THR47
2.372
|
References | Top | ||||
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REF 1 | Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. Structure. 2009 Apr 15;17(4):602-10. |
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