Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97747 | Target Info | |||
| Target Name | HUMAN C-C chemokine receptor 5 (CCR5) | ||||
| Synonyms | HIV-1 fusion coreceptor; HIV-1 fusion co-receptor; Chemokine receptor CCR5; CMKBR5; CHEMR13; CD195 antigen; CD195; CCR-5; CC-CKR-5; C-C CKR-5 | ||||
| Gene Name | CCR5 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | tyrosine O-sulfate | Ligand Info | |||
| Canonical SMILES | C1=CC(=CC=C1CC(C(=O)O)N)OS(=O)(=O)O | ||||
| InChI | 1S/C9H11NO6S/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H,13,14,15)/t8-/m0/s1 | ||||
| InChIKey | CIQHWLTYGMYQQR-QMMMGPOBSA-N | ||||
| PubChem Compound ID | 514186 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6MEO Structural basis of coreceptor recognition by HIV-1 envelope spike | ||||||
| Method | Electron microscopy | Resolution | 3.90 Å | Mutation | No | [1] |
| PDB Sequence |
MDYQVSSPID
11 INYTSEPCQK22 INVKQIAARL32 LPPLYSLVFI42 FGFVGNMLVI52 LILINCKRLK 62 SMTDIYLLNL72 AISDLFFLLT82 VPFWAHYAAA92 QWDFGNTMCQ102 LLTGLYFIGF 112 FSGIFFIILL122 TIDRYLAVVH132 AVFALKARTV142 TFGVVTSVIT152 WVVAVFASLP 162 GIIFTRSQKE172 GLHYTCSSHF182 PYSQYQFWKN192 FQTLKIVILG202 LVLPLLVMVI 212 CYSGILKTLL222 RCRNEKKRHR232 AVRLIFTIMI242 VYFLFWAPYN252 IVLLLNTFQE 262 FFGLNNCSSS272 NRLDQAMQVT282 ETLGMTHCCI292 NPIIYAFVGE302 KFRNYLLVFF 312 Q
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| PDB ID: 6MET Structural basis of coreceptor recognition by HIV-1 envelope spike | ||||||
| Method | Electron microscopy | Resolution | 4.50 Å | Mutation | No | [1] |
| PDB Sequence |
MDYQVSSPID
11 INYTSEPCQK22 INVKQIAARL32 LPPLYSLVFI42 FGFVGNMLVI52 LILINCKRLK 62 SMTDIYLLNL72 AISDLFFLLT82 VPFWAHYAAA92 QWDFGNTMCQ102 LLTGLYFIGF 112 FSGIFFIILL122 TIDRYLAVVH132 AVFALKARTV142 TFGVVTSVIT152 WVVAVFASLP 162 GIIFTRSQKE172 GLHYTCSSHF182 PYSQYQFWKN192 FQTLKIVILG202 LVLPLLVMVI 212 CYSGILKTLL222 RCRNEKKRHR232 AVRLIFTIMI242 VYFLFWAPYN252 IVLLLNTFQE 262 FFGLNNCSSS272 NRLDQAMQVT282 ETLGMTHCCI292 NPIIYAFVGE302 KFRNYLLVFF 312 Q
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of coreceptor recognition by HIV-1 envelope spike. Nature. 2019 Jan;565(7739):318-323. | ||||
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