Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T15776 Target Info
Target Name Pyruvate dehydrogenase kinase 1 (PDHK1)
Synonyms Pyruvate dehydrogenase kinase isoform 1; Pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial; PDHK1; PDH kinase 1
Target Type Clinical trial Target
Gene Name PDK1
Biochemical Class Kinase
UniProt ID
Q15118
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-138-1-3p miRNA Info
miRNA Mature AC
MIMAT0004607
Sequence gcuacuucacaacaccagggcc
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay; Western Blot [2]
Representative Target(s) Regulated by This miRNA Hypoxia-inducible factor 1 alpha (HIF-1A) Target Info
HIF1A_HUMAN
Pyruvate dehydrogenase kinase 1 (PDHK1) Target Info
PDK1_HUMAN
References  Top
REF 1 miR-138 inhibits proliferation by targeting 3-phosphoinositide-dependent protein kinase-1 in non-small cell lung cancer cells. Clin Respir J. 2015 Jan;9(1):27-33.
REF 2 miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1. Arch Toxicol. 2016 May;90(5):1239-49.

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