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| Target General Information |
Top |
| Target ID |
T47885 |
Target Info
|
| Target Name |
Protein kinase D (PRKD1) |
| Synonyms |
nPKC-mu; nPKC-D1; Serine/threonine-protein kinase D1; Protein kinase C mu type; PRKCM; PKD1; PKD |
| Target Type |
Literature-reported Target |
| Gene Name |
PRKD1 |
| Biochemical Class |
Kinase |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
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| miRNA Mature ID |
hsa-miR-124-3p |
miRNA Info
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| miRNA Mature AC |
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| Sequence |
uaaggcacgcggugaaugcc
|
| miRNA Species |
Homo sapiens |
| Evidence Score (E-score) |
1 |
+ |
| 1 |
Luciferase Reporter Assay |
[1] |
| Representative Target(s) Regulated by This miRNA |
Beta-secretase 1 (BACE1)
|
Target Info
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|
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Brain-derived neurotrophic factor (BDNF)
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Target Info
|
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| miRNA Mature ID |
hsa-miR-34a-5p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
uggcagugucuuagcugguugu
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
miR-34a negatively regulates PRKD1 by binding to the PRKD1 3'UTR. |
[2] |
| Evidence Score (E-score) |
1 |
+ |
| 1 |
Luciferase Reporter Assay; Western Blot |
[2] |
| Representative Target(s) Regulated by This miRNA |
Amphiregulin (AREG)
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Target Info
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Androgen receptor (AR)
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Target Info
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| References |
Top |
| REF 1 |
A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19291-6.
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| REF 2 |
A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/-catenin signaling in breast cancer. Oncotarget. 2016 Mar 22;7(12):14791-802.
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