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| Target General Information |
Top |
| Target ID |
T53270 |
Target Info
|
| Target Name |
Activating transcription factor 4 (ATF-4) |
| Synonyms |
cAMPresponsive elementbinding protein 2; cAMPdependent transcription factor ATF4; cAMP-responsive element-binding protein 2; cAMP-dependent transcription factor ATF-4; Taxresponsive enhancer elementbinding protein 67; TaxREB67; Tax-responsive enhancer element-binding protein 67; TXREB; DNAbinding protein TAXREB67; DNA-binding protein TAXREB67; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMPdependent transcription factor ATF4; Cyclic AMP-responsive element-binding protein 2; Cyclic AMP-dependent transcription factor ATF-4; CREB2; CREB-2 |
| Target Type |
Literature-reported Target |
| Gene Name |
ATF4 |
| Biochemical Class |
Basic leucine zipper bZIP |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
Top |
| miRNA Mature ID |
hsa-miR-214-3p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
acagcaggcacagacaggcagu
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| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
miR-214 directly targets ATF4. |
[1] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Luciferase Reporter Assay |
[1] |
| 2 |
Western Blot; RT-PCR |
[2] |
| Representative Target(s) Regulated by This miRNA |
Activating transcription factor 4 (ATF-4)
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Target Info
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|
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ADP-ribosylation factor-like protein 2 (ARL2)
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Target Info
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| References |
Top |
| REF 1 |
miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2013 Jan;19(1):93-100.
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| REF 2 |
MicroRNA-214 suppresses gluconeogenesis by targeting activating transcriptional factor 4. J Biol Chem. 2015 Mar 27;290(13):8185-95.
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