Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T53562 Target Info
Target Name X-ray repair cross-complementing 5 (Ku80)
Synonyms X-ray repair cross-complementing protein 5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); Thyroid-lupus autoantigen; TLAA; Nuclear factor IV; Lupus Ku autoantigen protein p86; Ku86; G22P2; DNA repair protein XRCC5; CTCBF; CTC85; CTC box-binding factor 85 kDa subunit; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase 2 subunit 2; 86 kDa subunit of Ku antigen
Target Type Literature-reported Target
Gene Name XRCC5
Biochemical Class Acid anhydride hydrolase
UniProt ID
P13010
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-31-5p miRNA Info
miRNA Mature AC
MIMAT0000089
Sequence aggcaagaugcuggcauagcu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [1]
Representative Target(s) Regulated by This miRNA Cyclin-dependent kinase 1 (CDK1) Target Info
CDK1_HUMAN
Dickkopf-related protein 1 (DKK1) Target Info
DKK1_HUMAN
miRNA Mature ID hsa-miR-526b-5p miRNA Info
miRNA Mature AC
MIMAT0002835
Sequence cucuugagggaagcacuuucugu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [2]
Representative Target(s) Regulated by This miRNA X-ray repair cross-complementing 5 (Ku80) Target Info
XRCC5_HUMAN
miRNA Mature ID hsa-miR-623 miRNA Info
miRNA Mature AC
MIMAT0003292
Sequence aucccuugcaggggcuguugggu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA X-ray repair cross-complementing 5 (Ku80) Target Info
XRCC5_HUMAN
References  Top
REF 1 K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression. Int J Cancer. 2015 Mar 15;136(6):1263-75.
REF 2 By downregulating Ku80, hsa-miR-526b suppresses non-small cell lung cancer. Oncotarget. 2015 Jan 30;6(3):1462-77.
REF 3 Hsa-miR-623 suppresses tumor progression in human lung adenocarcinoma. Cell Death Dis. 2016 Sep 29;7(9):e2388.

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