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Target General Information |
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Target ID |
T74312 |
Target Info
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Target Name |
Fms-like tyrosine kinase 3 (FLT-3) |
Synonyms |
Stem cell tyrosine kinase 1; STK1; STK-1; Receptor-type tyrosine-protein kinase FLT3; Fetal liver kinase-2; FLT-3; FLK2; FLK-2; FL cytokine receptor; CD135 |
Target Type |
Successful Target |
Gene Name |
FLT3 |
Biochemical Class |
Kinase |
UniProt ID |
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The microRNAs (miRNAs) Regulating This Target |
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miRNA Mature ID |
hsa-miR-150-5p |
miRNA Info
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miRNA Mature AC |
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Sequence |
ucucccaacccuuguaccagug
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miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-150 targeted the 3'UTR of FLT3 directly. |
[1] |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay |
[1] |
2 |
qPCR |
[2] |
Representative Target(s) Regulated by This miRNA |
Apoptosis inhibitor survivin (BIRC5)
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Target Info
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Beta-arrestin-2 (ARRB2)
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Target Info
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References |
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REF 1 |
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell. 2012 Oct 16;22(4):524-35.
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REF 2 |
MYSM1/miR-150/FLT3 inhibits B1a cell proliferation. Oncotarget. 2016 Oct 18;7(42):68086-68096.
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