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| Target General Information |
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| Target ID |
T99686 |
Target Info
|
| Target Name |
Integrin alpha-4/beta-4 (ITGA4/B4) |
| Synonyms |
alpha(4)beta(4) integrin; Alpha 4 beta 4 integrin |
| Target Type |
Literature-reported Target |
| Gene Name |
ITGA4-ITGB4 |
| Biochemical Class |
Integrin |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
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| miRNA Mature ID |
hsa-miR-143-3p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
ugagaugaagcacuguagcuc
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
Transfection with miR-143 mimics resulted in decreased level of both mRNA and protein expression. |
[1] |
| Evidence Score (E-score) |
1 |
+ |
| 1 |
qRT-PCR; Western Blot |
[1] |
| Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
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|
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Connective tissue growth factor (CTGF)
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Target Info
|
|
| miRNA Mature ID |
hsa-miR-204-5p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
uucccuuugucauccuaugccu
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
The overexpression of miR-204-5p by mature miRNA transfection resulted in the changed mRNA level of target ITGB4. |
[2] |
| Evidence Score (E-score) |
1 |
+ |
| 1 |
qRT-PCR |
[2] |
| Representative Target(s) Regulated by This miRNA |
Alkaline phosphatase tissue-nonspecific (ALPL)
|
Target Info
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|
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Apoptosis regulator Bcl-2 (BCL-2)
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Target Info
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| References |
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| REF 1 |
miR-143 down-regulates TLR2 expression in hepatoma cells and inhibits hepatoma cell proliferation and invasion. Int J Clin Exp Pathol. 2015 Oct 1;8(10):12738-47.
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| REF 2 |
Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis. PLoS Comput Biol. 2010 Apr 1;6(4):e1000730.
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