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| Target General Information |
Top |
| Target ID |
T00494 |
Target Info
|
| Target Name |
ATP-binding cassette transporter A1 (ABCA1) |
| Synonyms |
Cholesterol mobilizing transporter ABCA1; Cholesterol efflux regulatory protein; CERP; ATP-binding cassette transporter (ABCA1) transmembrane protein; ATP-binding cassette sub-family A member 1; ATP-binding cassette 1; ABC1; ABC-1 |
| Target Type |
Successful Target |
| Gene Name |
ABCA1 |
| Biochemical Class |
ABC transporter |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Other proteins |
[+] 1 Other proteins |
+ |
| Interacting Target Name |
Apolipoprotein A-I (APOA1) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Truncated apolipoprotein AI; Apolipoprotein A-I; Apolipoprotein A1; Apo-AI; ApoA-I; ApoAI |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 ... Atherosclerosis. 2016 May;248:149-59.
|
| REF 2 |
Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem. 2002 Sep 6;277(36):33178-87.
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