Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02677 | Target Info | |||
| Target Name | Apoptosis inhibitor survivin (BIRC5) | ||||
| Synonyms | Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; API4 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | BIRC5 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 2 Acyltransferases | + | |||
| Interacting Target Name | X-linked inhibitor of apoptosis protein (XIAP) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Reconstituted Complex | [2] | |||
| Interacting Target Name | Cellular inhibitor of apoptosis 1 (BIRC2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Reconstituted Complex | [2] | |||
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Aurora kinase B (AURKB) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | STK5; STK12; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora/IPL1-related kinase 2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK-2; ARK2; AIRK2; AIM-1; AIM1; AIK2 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Co-localization | [5] | |||
| 3 | Reconstituted Complex | [6] | |||
| 4 | Yeast two hybrid | [7] | |||
| Peptidases | [+] 3 Peptidases | + | |||
| Interacting Target Name | Caspase-3 (CASP3) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [8] | |||
| 2 | Reconstituted Complex | [9] | |||
| Interacting Target Name | Caspase-9 (CASP9) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; APAF-3 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [10] | |||
| 2 | Co-localization | [11] | |||
| Interacting Target Name | Caspase-7 (CASP7) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [8] | |||
| 2 | Reconstituted Complex | [9] | |||
| Other proteins | [+] 3 Other proteins | + | |||
| Interacting Target Name | Borealin (CDCA8) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Pluripotent embryonic stem cell-related gene 3 protein; Pluripotent embryonic stem cellrelated gene 3 protein; PESCRG3; hDasra-B; hDasraB; Dasra-B; DasraB; Dasra B; Cell division cycle-associated protein 8; Cell division cycleassociated protein 8 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [12] | |||
| 2 | Affinity Capture-Western | [4] | |||
| 3 | Reconstituted Complex | [4] | |||
| 4 | Yeast two hybrid | [13] | |||
| Interacting Protein Name | Inner centromere protein (INCENP) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [12] | |||
| 2 | Affinity Capture-Western | [4] | |||
| 3 | Co-localization | [7] | |||
| 4 | Reconstituted Complex | [7] | |||
| Interacting Target Name | Direct IAP-binding protein with low pI (DIABLO) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Smac protein; Smac; Second mitochondria-derived activator of caspase; Direct IAP binding protein with low pI; Diablo homolog, mitochondrial | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [14] | |||
| 2 | Fluorescence Resonance Energy Transfer | [15] | |||
| 3 | Reconstituted Complex | [15] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. J Biol Chem. 2007 Sep 7;282(36):26202-9. | ||||
| REF 2 | An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13;279(33):34087-90. | ||||
| REF 3 | Cellular inhibitor of apoptosis protein 1 (cIAP1) stability contributes to YM155 resistance in human gastric cancer cells. J Biol Chem. 2015 Apr 17;290(16):9974-85. | ||||
| REF 4 | The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 2006 Dec;7(12):1259-65. | ||||
| REF 5 | INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol. 2009 Nov 30;187(5):637-53. | ||||
| REF 6 | Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. J Biol Chem. 2003 Jan 3;278(1):486-90. | ||||
| REF 7 | INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol. 2001 Jun 5;11(11):886-90. | ||||
| REF 8 | An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry. 2001 Jan 30;40(4):1117-23. | ||||
| REF 9 | IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20. | ||||
| REF 10 | Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13103-7. | ||||
| REF 11 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
| REF 12 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 13 | Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell. 2007 Oct 19;131(2):271-85. | ||||
| REF 14 | Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. J Biol Chem. 2003 Jun 20;278(25):23130-40. | ||||
| REF 15 | Survivin monomer plays an essential role in apoptosis regulation. J Biol Chem. 2011 Jul 1;286(26):23296-307. | ||||
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