Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T03556 Target Info
Target Name Hepatocyte nuclear factor 1-alpha (HNF1A)
Synonyms Transcription factor-1; Transcription factor 1; TCF1; TCF-1; Liver-specific transcription factor LF-B1; Liver specific transcription factor LF-B1; LFB1; HNF-1A; HNF-1-alpha; HNF-1 alpha
Target Type Clinical trial Target
Gene Name HNF1A
UniProt ID
HNF1A_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
Lyases [+] 1 Lyases +
Interacting Protein Name Pterin-4-alpha-carbinolamine dehydratase (PCBD1) Interacting Protein Interacting Protein Info
UniProt ID
PHS_HUMAN 
Synonyms DCOH; PCBD; PCD; PHS
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [4]
4 Reconstituted Complex [3]
5 Yeast two hybrid [3]
6 Yeast two hybrid [5]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [7]
References  Top
REF 1 Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. Diabetes. 2002 May;51(5):1409-18.
REF 2 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 3 The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity. Nucleic Acids Res. 1997 Apr 15;25(8):1476-84.
REF 4 Kinetic stability may determine the interaction dynamics of the bifunctional protein DCoH1, the dimerization cofactor of the transcription factor HNF-1 . Biochemistry. 2010 Nov 30;49(47):10187-97.
REF 5 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 6 Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes. J Biochem. 2004 Sep;136(3):313-9.
REF 7 Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins. J Biol Chem. 2000 Apr 28;275(17):12515-20.

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