Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T04393 Target Info
Target Name E3 ubiquitin protein ligase CBLB (CBLB)
Synonyms Signal transduction protein CBLB; Signal transduction protein CBL-B; SH3binding protein CBLB; SH3-binding protein CBL-B; RNF56; RING-type E3 ubiquitin transferase CBL-B; RING finger protein 56; Nbla00127; E3 ubiquitinprotein ligase CBLB; E3 ubiquitin-protein ligase CBL-B; Casitas Blineage lymphoma protooncogene b; Casitas B-lineage lymphoma proto-oncogene b
Target Type Literature-reported Target
Gene Name CBLB
Biochemical Class Acyltransferase
UniProt ID
CBLB_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Yeast two hybrid [6]
Interacting Protein Name SH3 domain-containing kinase-binding protein 1 (SH3KBP1) Interacting Protein Interacting Protein Info
UniProt ID
SH3K1_HUMAN 
Synonyms CD2BP3; CIN85; GIG10; HSB.1; HSB1; MIG18
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Reconstituted Complex [9]
Kinases [+] 2 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [11]
3 Biochemical Activity [12]
Interacting Target Name Tyrosine-protein kinase SYK (SYK) Successful Target Interacting Protein Info
UniProt ID
KSYK_HUMAN 
Synonyms Spleen tyrosine kinase; p72-Syk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [13]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [14]
2 Reconstituted Complex [15]
Other proteins [+] 3 Other proteins +
Interacting Target Name Proto-oncogene c-Crk (c-Crk) Literature-reported Target Interacting Protein Info
UniProt ID
CRK_HUMAN 
Synonyms P38; Adapter molecule crk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [16]
Interacting Protein Name CD2-associated protein (CD2AP) Interacting Protein Interacting Protein Info
UniProt ID
CD2AP_HUMAN 
Synonyms CMS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Co-crystal Structure [9]
Interacting Protein Name Crk-like protein (CRKL) Interacting Protein Interacting Protein Info
UniProt ID
CRKL_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Yeast two hybrid [16]
References  Top
REF 1 Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9.
REF 2 The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor (PDGFR) Internalization and Signaling. J Biol Chem. 2016 May 27;291(22):11608-18.
REF 3 The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells. J Biol Chem. 1998 Jun 12;273(24):14962-7.
REF 4 cbl-b inhibits epidermal growth factor receptor signaling. Oncogene. 1999 Mar 11;18(10):1855-66.
REF 5 Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene. 1999 Feb 4;18(5):1147-56.
REF 6 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 7 CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. J Biol Chem. 2002 Oct 18;277(42):39666-72.
REF 8 Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J Biol Chem. 2003 Oct 10;278(41):39735-46.
REF 9 Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*. FEBS J. 2013 Jul;280(14):3399-415.
REF 10 EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins. Oncogene. 2006 Oct 19;25(49):6497-509.
REF 11 Cylindromatosis Tumor Suppressor Protein (CYLD) Deubiquitinase is Necessary for Proper Ubiquitination and Degradation of the Epidermal Growth Factor Receptor. Mol Cell Proteomics. 2017 Aug;16(8):1433-1446.
REF 12 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell. 1999 Dec;4(6):1029-40.
REF 13 Inhibition of CBLB protects from lethal Candida albicans sepsis. Nat Med. 2016 Aug;22(8):915-23.
REF 14 Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. Oncogene. 2004 Mar 4;23(9):1645-55.
REF 15 Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat Struct Mol Biol. 2005 Aug;12(8):708-14.
REF 16 Phospho-tyrosine dependent protein-protein interaction network. Mol Syst Biol. 2015 Mar 26;11(3):794.
REF 17 Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J Biol Chem. 2006 Dec 15;281(50):38845-53.

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