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| Target General Information |
Top |
| Target ID |
T05661 |
Target Info
|
| Target Name |
Lecithin-cholesterol acyltransferase (LCAT) |
| Synonyms |
Phospholipidcholesterolacyltransferase; Phospholipid-cholesterol acyltransferase; Phosphatidylcholinesterol acyltransferase; Phosphatidylcholine-sterol acyltransferase |
| Target Type |
Clinical trial Target |
| Gene Name |
LCAT |
| Biochemical Class |
Acyltransferase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Other proteins |
[+] 1 Other proteins |
+ |
| Interacting Target Name |
Apolipoprotein A-I (APOA1) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Truncated apolipoprotein AI; Apolipoprotein A-I; Apolipoprotein A1; Apo-AI; ApoA-I; ApoAI |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Biochemical Activity |
[1] |
| 2 |
Biochemical Activity |
[2] |
| 3 |
Reconstituted Complex |
[3] |
| 4 |
Reconstituted Complex |
[4] |
| References |
Top |
| REF 1 |
A protein cofactor of lecithin:cholesterol acyltransferase. Biochem Biophys Res Commun. 1972 Feb 25;46(4):1493-8.
|
| REF 2 |
Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry. 2005 Jan 25;44(3):1013-25.
|
| REF 3 |
Secretion of lecithin:cholesterol acyltransferase by brain neuroglial cell lines. Biochem Biophys Res Commun. 1999 Apr 29;258(1):73-6.
|
| REF 4 |
Effect of apolipoprotein A-I lipidation on the formation and function of pre-beta and alpha-migrating LpA-I particles. Biochemistry. 1999 Feb 9;38(6):1727-35.
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