Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T07394 Target Info
Target Name Notch-1 receptor (NOTCH1)
Synonyms hN1; Translocationassociated notch protein TAN1; Translocation-associated notch protein TAN-1; TAN1; Notch 1 intracellular domain; Notch 1; Neurogenic locus notch homolog protein 1; NICD
Target Type Clinical trial Target
Gene Name NOTCH1
Biochemical Class Notch protein
UniProt ID
NOTC1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Yeast two hybrid [2]
Interacting Protein Name E3 ubiquitin-protein ligase DTX1 (DTX1) Interacting Protein Interacting Protein Info
UniProt ID
DTX1_HUMAN 
Synonyms hDx.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Kinases [+] 1 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Yeast two hybrid [6]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Recombining binding protein suppressor of hairless (RBPJ) Literature-reported Target Interacting Protein Info
UniProt ID
SUH_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-30; RBPSUH; RBP-JK; RBPJK; RBP-J kappa; RBP-J; J kappa-recombination signal-binding protein; IGKJRB1; IGKJRB; CBF-1
Evidence Score (E-score) 16 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [9]
6 Affinity Capture-Western [10]
7 Affinity Capture-Western [11]
8 Affinity Capture-Western [12]
9 Affinity Capture-Western [13]
10 Affinity Capture-Western [14]
11 Affinity Capture-Western [15]
12 Affinity Capture-Western [16]
13 Co-fractionation [11]
14 Co-localization [17]
15 Reconstituted Complex [18]
16 Reconstituted Complex [4]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Reconstituted Complex [20]
Other proteins [+] 4 Other proteins +
Interacting Target Name F-box and WD-40 domain protein 7 (Fbxw7) Literature-reported Target Interacting Protein Info
UniProt ID
FBXW7_HUMAN 
Synonyms SEL-10; SEL10; hCdc4; hAgo; FBX30; FBW7; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; F-box protein Fbxw6; F-box protein FBX30; F-box protein FBW7; F-box and WD-40 domain-containing protein 7; Archipelago homolog
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [21]
3 Affinity Capture-Western [22]
4 Affinity Capture-Western [23]
5 Affinity Capture-Western [24]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [10]
8 Protein-Fragment Complementation Assay [6]
9 Reconstituted Complex [25]
Interacting Protein Name Mastermind-like protein 1 (MAML1) Interacting Protein Interacting Protein Info
UniProt ID
MAML1_HUMAN 
Synonyms Mam.1; Mam1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [26]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [10]
6 Affinity Capture-Western [11]
7 Affinity Capture-Western [12]
8 Yeast two hybrid [27]
Interacting Protein Name Protein jagged-1 (JAG1) Interacting Protein Interacting Protein Info
UniProt ID
JAG1_HUMAN 
Synonyms AGS; AHD; AWS; CD339; HJ1; JAGL1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [28]
Interacting Protein Name Mastermind-like protein 3 (MAML3) Interacting Protein Interacting Protein Info
UniProt ID
MAML3_HUMAN 
Synonyms CAGH3; ERDA3; GDN; MAM.2; MAM2; TNRC3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Yeast two hybrid [27]
References  Top
REF 1 Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene. 2010 Jan 14;29(2):201-13.
REF 2 Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1. Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):300-6.
REF 3 Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. J Biol Chem. 2001 Nov 30;276(48):45031-40.
REF 4 Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem. 2007 Aug 17;282(33):24027-38.
REF 5 Down-regulation of Notch-dependent transcription by Akt in vitro. FEBS Lett. 2008 May 28;582(12):1693-9.
REF 6 Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. BMC Cancer. 2016 May 26;16:335.
REF 7 NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Mol Cell. 2012 Nov 9;48(3):445-58.
REF 8 Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. J Biol Chem. 1997 Apr 25;272(17):11336-43.
REF 9 Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase. Mol Cell Biol. 2007 Aug;27(15):5565-74.
REF 10 The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase. Exp Cell Res. 2011 Oct 15;317(17):2438-46.
REF 11 Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol. 2002 Jun;22(11):3927-41.
REF 12 A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. Mol Cell Biol. 2001 Jul;21(13):4337-46.
REF 13 RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells. Exp Cell Res. 2010 Jan 15;316(2):149-57.
REF 14 Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation. Mol Cell Biol. 2007 Sep;27(18):6506-19.
REF 15 Alpha-synuclein negatively regulates Notch1 intracellular domain protein stability through promoting interaction with Fbw7. Neurosci Lett. 2015 Jul 23;600:6-11.
REF 16 The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling. J Biol Chem. 2009 May 15;284(20):13384-95.
REF 17 Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20778-83.
REF 18 Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem. 2003 Jun 6;278(23):21232-9.
REF 19 Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. BMC Biol. 2011 Nov 30;9:83.
REF 20 Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway. Biochem J. 2013 Mar 15;450(3):523-36.
REF 21 Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem. 2001 Sep 14;276(37):34371-8.
REF 22 Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain. Oncotarget. 2016 Nov 29;7(48):79047-79063.
REF 23 The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med. 2007 Aug 6;204(8):1825-35.
REF 24 FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med. 2007 Aug 6;204(8):1813-24.
REF 25 MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells. Oncogene. 2017 Aug 31;36(35):5023-5034.
REF 26 MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet. 2000 Dec;26(4):484-9.
REF 27 Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol. 2002 Nov;22(21):7688-700.
REF 28 Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. Biochem Biophys Res Commun. 2000 Sep 16;276(1):385-9.

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