Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T07930 Target Info
Target Name Histone deacetylase 5 (HDAC5)
Synonyms KIAA0600; HD5; Antigen NY-CO-9
Target Type Patented-recorded Target
Gene Name HDAC5
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID
HDAC5_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Beta-transducin repeats [+] 2 Beta-transducin repeats +
Interacting Protein Name F-box-like/WD repeat-containing protein TBL1X (TBL1X) Interacting Protein Interacting Protein Info
UniProt ID
TBL1X_HUMAN 
Synonyms EBI; SMAP55; TBL1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Interacting Target Name Transducin beta-like 1X-related protein 1 (TBL1XR1) Literature-reported Target Interacting Protein Info
UniProt ID
TBL1R_HUMAN 
Synonyms Transducin betalike 1Xrelated protein 1; TBLR1; TBL1-related protein 1; TBL1related protein 1; Nuclear receptor corepressor/HDAC3 complexsubunit TBLR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; IRA1; F-box-like/WD repeat-containing protein TBL1XR1; Fboxlike/WD repeatcontaining protein TBL1XR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [3]
6 Affinity Capture-Western [1]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Serine/threonine PP2A-alpha (PPP2CA) Clinical trial Target Interacting Protein Info
UniProt ID
PP2AA_HUMAN 
Synonyms Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; RP-C; Replication protein C; PP2A-alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
Interacting Protein Name PP2A subunit B isoform PR55-alpha (PPP2R2A) Interacting Protein Interacting Protein Info
UniProt ID
2ABA_HUMAN 
Synonyms B55A; B55ALPHA; PR52A; PR55A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Kinases [+] 1 Kinases +
Interacting Target Name Protein kinase D (PRKD1) Literature-reported Target Interacting Protein Info
UniProt ID
KPCD1_HUMAN 
Synonyms Serine/threonine-protein kinase D1; Protein kinase C mu type; PRKCM; PKD1; PKD; nPKC-mu; nPKC-D1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [10]
Proteins 14-3-3 [+] 5 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [11]
5 Affinity Capture-Western [12]
6 Yeast two hybrid [8]
Interacting Protein Name 14-3-3 protein epsilon (YWHAE) Interacting Protein Interacting Protein Info
UniProt ID
1433E_HUMAN 
Synonyms 14.3.3E; HEL2; KCIP.1; MDCR; MDS
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [1]
5 Affinity Capture-Western [13]
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [4]
Interacting Protein Name 14-3-3 protein gamma (YWHAG) Interacting Protein Interacting Protein Info
UniProt ID
1433G_HUMAN 
Synonyms 14.3.3GAMMA; PPP1R170
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [14]
Interacting Target Name AS1 14-3-3 protein eta (YWHAH) Literature-reported Target Interacting Protein Info
UniProt ID
1433F_HUMAN 
Synonyms YWHA1; Protein AS1; 14-3-3 protein eta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Interacting Protein Name G protein pathway suppressor 2 (GPS2) Interacting Protein Interacting Protein Info
UniProt ID
GPS2_HUMAN 
Synonyms AMF.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
Interacting Protein Name Zinc finger and BTB domain-containing protein 16 (ZBTB16) Interacting Protein Interacting Protein Info
UniProt ID
ZBT16_HUMAN 
Synonyms PLZF; ZNF145
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Reconstituted Complex [16]
Other proteins [+] 3 Other proteins +
Interacting Target Name Prohibitin (PHB) Literature-reported Target Interacting Protein Info
UniProt ID
PHB_HUMAN 
Synonyms PHB1; HEL-215; HEL-S-54e
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Ankyrin repeat family A protein 2 (ANKRA2) Interacting Protein Interacting Protein Info
UniProt ID
ANRA2_HUMAN 
Synonyms ANKRA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [18]
Interacting Protein Name Elongation factor 1-gamma (EEF1G) Interacting Protein Interacting Protein Info
UniProt ID
EF1G_HUMAN 
Synonyms EF1G; GIG35
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [19]
References  Top
REF 1 Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Mol Cell Proteomics. 2011 Feb;10(2):M110.004317.
REF 2 The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol. 2013;9:672.
REF 3 The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell. 2002 Mar;9(3):611-23.
REF 4 Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7835-40.
REF 5 Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4868-73.
REF 6 Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell. 2002 Jan;9(1):45-57.
REF 7 Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4727-32.
REF 8 Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol. 2004 Oct;24(19):8374-85.
REF 9 A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. J Biol Chem. 2005 Apr 15;280(15):15013-9.
REF 10 Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression. Circ Res. 2015 Aug 14;117(5):424-36.
REF 11 The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases. J Biol Chem. 2013 Mar 29;288(13):9345-62.
REF 12 PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15467-72.
REF 13 Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1. J Biol Chem. 2014 Jul 25;289(30):21108-19.
REF 14 AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell. 2008 Oct 24;32(2):169-79.
REF 15 HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF. Oncogene. 2004 Nov 18;23(54):8777-84.
REF 16 Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. J Biol Chem. 2002 Jun 14;277(24):22045-52.
REF 17 Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. Structure. 2015 Apr 7;23(4):700-12.
REF 18 Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. J Biol Chem. 2005 Aug 12;280(32):29117-27.
REF 19 A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.