Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T07958 | Target Info | |||
Target Name | Erythropoietin (EPO) | ||||
Synonyms | Epoetin | ||||
Target Type | Clinical trial Target | ||||
Gene Name | EPO | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Cytokine receptors | [+] 1 Cytokine receptors | + | |||
Interacting Target Name | Erythropoietin Receptor (EPOR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Full-length form; EPO-R | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
3 | Reconstituted Complex | [3] | |||
4 | Reconstituted Complex | [4] | |||
5 | Yeast two hybrid | [5] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 2 | beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation. Blood. 2007 Jun 15;109(12):5215-22. | ||||
REF 3 | Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide. J Biol Chem. 1999 May 14;274(20):14163-9. | ||||
REF 4 | An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nat Struct Biol. 1998 Nov;5(11):993-1004. | ||||
REF 5 | Both proteasomes and lysosomes degrade the activated erythropoietin receptor. Blood. 2005 Jan 15;105(2):600-8. |
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