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| Target General Information |
Top |
| Target ID |
T09092 |
Target Info
|
| Target Name |
Interleukin-10 (IL10) |
| Synonyms |
IL-10; Cytokine synthesis inhibitory factor; CSIF |
| Target Type |
Clinical trial Target |
| Gene Name |
IL10 |
| Biochemical Class |
Cytokine: interleukin |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Cytokine receptors |
[+] 1 Cytokine receptors |
+ |
| Interacting Protein Name |
Interleukin-10 receptor subunit alpha (IL10RA) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
CD210; CD210a; CDW210A; HIL.10R; IL.10R1; IL10R |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Co-crystal Structure |
[1] |
| 2 |
Co-crystal Structure |
[2] |
| 3 |
Reconstituted Complex |
[3] |
| 4 |
Reconstituted Complex |
[4] |
| References |
Top |
| REF 1 |
Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 2001 Jul;15(1):35-46.
|
| REF 2 |
Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization. Eur J Biochem. 1999 May;262(1):134-41.
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| REF 3 |
Characterization of recombinant extracellular domain of human interleukin-10 receptor. J Biol Chem. 1995 May 26;270(21):12906-11.
|
| REF 4 |
Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1. Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1908-11.
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