Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T10147 Target Info
Target Name Protein-tyrosine phosphatase sigma (R-PTP-sigma)
Synonyms Receptor-type tyrosine-protein phosphatase sigma; Receptor-type tyrosine-protein phosphatase S; R-PTP-S
Target Type Successful Target
Gene Name PTPRS
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PTPRS_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Receptor-type tyrosine-protein phosphatase delta (PTPRD) Interacting Protein Interacting Protein Info
UniProt ID
PTPRD_HUMAN 
Synonyms HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [2]
3 Yeast two hybrid [1]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Liprin-alpha-1 (PPFIA1) Interacting Protein Interacting Protein Info
UniProt ID
LIPA1_HUMAN 
Synonyms LIP.1; LIP1; LIPRIN
Evidence Score (E-score) 3 Experimental Evidences +
1 Proximity Label-MS [3]
2 Reconstituted Complex [4]
3 Yeast two hybrid [5]
References  Top
REF 1 The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma. Mol Cell Biol. 1998 May;18(5):2608-16.
REF 2 Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule. J Neurosci. 2012 Feb 22;32(8):2588-600.
REF 3 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
REF 4 The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are exp... Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11686-90.
REF 5 Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J Biol Chem. 1998 Jun 19;273(25):15611-20.

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