Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T11966 Target Info
Target Name Cyclic-AMP-dependent transcription factor ATF-3 (ATF3)
Synonyms cAMP-dependent transcription factor ATF-3; Cyclic AMP-dependent transcription factor ATF-3; Activating transcription factor 3
Target Type Literature-reported Target
Gene Name ATF3
Biochemical Class Basic leucine zipper bZIP
UniProt ID
ATF3_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Cyclic AMP-dependent transcription factor ATF-2 (ATF2) Interacting Protein Interacting Protein Info
UniProt ID
ATF2_HUMAN 
Synonyms CRE.BP1; CREB.2; CREB2; HB16; TREB7
Evidence Score (E-score) 2 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [1]
2 Yeast two hybrid [2]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [3]
3 Yeast two hybrid [4]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [7]
4 Fluorescence Resonance Energy Transfer [1]
5 Reconstituted Complex [8]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Interacting Target Name Activating transcription factor 4 (ATF-4) Literature-reported Target Interacting Protein Info
UniProt ID
ATF4_HUMAN 
Synonyms TXREB; Tax-responsive enhancer element-binding protein 67; Taxresponsive enhancer elementbinding protein 67; TaxREB67; DNA-binding protein TAXREB67; DNAbinding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMPdependent transcription factor ATF4; CREB-2; CREB2; cAMP-responsive element-binding protein 2; cAMPresponsive elementbinding protein 2; cAMP-dependent transcription factor ATF-4; cAMPdependent transcription factor ATF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Fluorescence Resonance Energy Transfer [1]
Interacting Protein Name CCAAT/enhancer-binding protein epsilon (CEBPE) Interacting Protein Interacting Protein Info
UniProt ID
CEBPE_HUMAN 
Synonyms C/EBP.epsilon; CRP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [12]
2 Fluorescence Resonance Energy Transfer [1]
Interacting Protein Name DDIT3 upstream open reading frame protein (DDIT3) Interacting Protein Interacting Protein Info
UniProt ID
DT3UO_HUMAN 
Synonyms CEBPZ; CHOP; CHOP.10; CHOP10; GADD153
Evidence Score (E-score) 2 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [1]
2 Yeast two hybrid [13]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [14]
2 Reconstituted Complex [14]
References  Top
REF 1 Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4.
REF 2 An atlas of combinatorial transcriptional regulation in mouse and man. Cell. 2010 Mar 5;140(5):744-52.
REF 3 Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J. 2005 Jul 6;24(13):2425-35.
REF 4 A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68.
REF 5 ATF3 enhances c-Jun-mediated neurite sprouting. Brain Res Mol Brain Res. 2003 Dec 12;120(1):38-45.
REF 6 Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol Cell Biol. 1996 Mar;16(3):1157-68.
REF 7 Activating transcription factor 3 is a positive regulator of human IFNG gene expression. J Immunol. 2010 May 1;184(9):4990-9.
REF 8 Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3720-4.
REF 9 ATF3, an adaptive-response gene, enhances TGF{beta} signaling and cancer-initiating cell features in breast cancer cells. J Cell Sci. 2010 Oct 15;123(Pt 20):3558-65.
REF 10 A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell. 2003 Apr;11(4):915-26.
REF 11 ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2200-5.
REF 12 A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem J. 2007 Feb 15;402(1):163-73.
REF 13 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.
REF 14 MDM2 mediates ubiquitination and degradation of activating transcription factor 3. J Biol Chem. 2010 Aug 27;285(35):26908-15.

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