Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12909 | Target Info | |||
| Target Name | Dystrophin (DMD) | ||||
| Synonyms | Dystrophin | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | DMD | ||||
| Biochemical Class | Dystrophin protein | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Adapter proteins | [+] 3 Adapter proteins | + | |||
| Interacting Protein Name | Alpha-1-syntrophin (SNTA1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | LQT12; SNT1; TACIP1; dJ1187J4.5 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Reconstituted Complex | [2] | |||
| Interacting Protein Name | Beta-1-syntrophin (SNTB1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | 59.DAP; A1B; BSYN2; DAPA1B; SNT2; SNT2B1; TIP.43 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Reconstituted Complex | [3] | |||
| Interacting Protein Name | Beta-2-syntrophin (SNTB2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | D16S2531E; EST25263; SNT2B2; SNT3; SNTL | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [4] | |||
| Putative transporters | [+] 1 Putative transporters | + | |||
| Interacting Target Name | Dystroglycan (DAG1) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Dystrophin-associated glycoprotein 1; Alpha-dystroglycan | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Co-crystal Structure | [6] | |||
| Other proteins | [+] 3 Other proteins | + | |||
| Interacting Protein Name | Alpha-catulin (CTNNAL1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ACRP; CLLP; alpha.CATU | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Yeast two hybrid | [7] | |||
| Interacting Protein Name | Dystrobrevin beta (DTNB) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Yeast two hybrid | [7] | |||
| Interacting Protein Name | HAUS augmin-like complex subunit 1 (HAUS1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CCDC5; HEI.C; HEIC; HsT1461 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Yeast two hybrid | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 2 | Identification of alpha-syntrophin binding to syntrophin triplet, dystrophin, and utrophin. J Biol Chem. 1995 Mar 10;270(10):4975-8. | ||||
| REF 3 | Syntrophin binds to an alternatively spliced exon of dystrophin. J Cell Biol. 1995 Feb;128(3):363-71. | ||||
| REF 4 | Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins. PLoS One. 2012;7(8):e43515. | ||||
| REF 5 | Identification and characterization of the dystrophin anchoring site on beta-dystroglycan. J Biol Chem. 1995 Nov 10;270(45):27305-10. | ||||
| REF 6 | Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan. Nat Struct Biol. 2000 Aug;7(8):634-8. | ||||
| REF 7 | A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226. | ||||
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