Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T12909 | Target Info | |||
Target Name | Dystrophin (DMD) | ||||
Synonyms | Dystrophin | ||||
Target Type | Clinical trial Target | ||||
Gene Name | DMD | ||||
Biochemical Class | Dystrophin protein | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Adapter proteins | [+] 3 Adapter proteins | + | |||
Interacting Protein Name | Alpha-1-syntrophin (SNTA1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | LQT12; SNT1; TACIP1; dJ1187J4.5 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Reconstituted Complex | [2] | |||
Interacting Protein Name | Beta-1-syntrophin (SNTB1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | 59.DAP; A1B; BSYN2; DAPA1B; SNT2; SNT2B1; TIP.43 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Reconstituted Complex | [3] | |||
Interacting Protein Name | Beta-2-syntrophin (SNTB2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | D16S2531E; EST25263; SNT2B2; SNT3; SNTL | ||||
Evidence Score (E-score) | 1 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [4] | |||
Putative transporters | [+] 1 Putative transporters | + | |||
Interacting Target Name | Dystroglycan (DAG1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Dystrophin-associated glycoprotein 1; Alpha-dystroglycan | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [5] | |||
2 | Co-crystal Structure | [6] | |||
Other proteins | [+] 3 Other proteins | + | |||
Interacting Protein Name | Alpha-catulin (CTNNAL1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ACRP; CLLP; alpha.CATU | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Yeast two hybrid | [7] | |||
Interacting Protein Name | Dystrobrevin beta (DTNB) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Yeast two hybrid | [7] | |||
Interacting Protein Name | HAUS augmin-like complex subunit 1 (HAUS1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CCDC5; HEI.C; HEIC; HsT1461 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Yeast two hybrid | [7] |
References | Top | ||||
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REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 2 | Identification of alpha-syntrophin binding to syntrophin triplet, dystrophin, and utrophin. J Biol Chem. 1995 Mar 10;270(10):4975-8. | ||||
REF 3 | Syntrophin binds to an alternatively spliced exon of dystrophin. J Cell Biol. 1995 Feb;128(3):363-71. | ||||
REF 4 | Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins. PLoS One. 2012;7(8):e43515. | ||||
REF 5 | Identification and characterization of the dystrophin anchoring site on beta-dystroglycan. J Biol Chem. 1995 Nov 10;270(45):27305-10. | ||||
REF 6 | Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan. Nat Struct Biol. 2000 Aug;7(8):634-8. | ||||
REF 7 | A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226. |
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