Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12952 Target Info
Target Name VHL-interacting deubiquitinating enzyme 1 (VDU1)
Synonyms hVDU1; Ubiquitin-specific-processing protease 33; Ubiquitin thioesterase 33; Ubiquitin carboxyl-terminal hydrolase 33; KIAA1097; Deubiquitinating enzyme 33
Target Type Patented-recorded Target
Gene Name USP33
Biochemical Class Peptidase
UniProt ID
UBP33_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 2 Other proteins +
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [1]
3 Reconstituted Complex [1]
4 Yeast two hybrid [1]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [3]
3 Biochemical Activity [4]
4 Biochemical Activity [2]
References  Top
REF 1 Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2002 Feb 15;277(7):4656-62.
REF 2 Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6650-5.
REF 3 Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into -arrestin-dependent ERK signaling. Oncotarget. 2016 Dec 6;7(49):81223-81240.
REF 4 Deubiquitinases and their emerging roles in -arrestin-mediated signaling. Methods Enzymol. 2014;535:351-70.

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