Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T15000 Target Info
Target Name Cytotoxic T-lymphocyte protein 4 (CTLA-4)
Synonyms Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152
Target Type Successful Target
Gene Name CTLA4
Biochemical Class Immunoglobulin
UniProt ID
CTLA4_HUMAN 
Target Interacting Proteins  Top
Putative transporters [+] 1 Putative transporters +
Interacting Protein Name AP-2 complex subunit mu (AP2M1) Interacting Protein Interacting Protein Info
UniProt ID
AP2M1_HUMAN 
Synonyms AP50; CLAPM1; mu2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-crystal Structure [2]
3 Reconstituted Complex [1]
4 Yeast two hybrid [1]
Other proteins [+] 2 Other proteins +
Interacting Target Name T-lymphocyte activation antigen CD86 (FUN1) Successful Target Interacting Protein Info
UniProt ID
CD86_HUMAN 
Synonyms FUN-1; CTLA-4 counter-receptor B7.2; CD86; CD28LG2; BU63; B70; Activation B7-2 antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [3]
2 Reconstituted Complex [4]
Interacting Target Name Activation B7-1 antigen (CD80) Successful Target Interacting Protein Info
UniProt ID
CD80_HUMAN 
Synonyms T-lymphocyte activation antigen CD80; LAB7; CTLA-4 counter-receptor B7.1; CD28LG1; CD28LG; BB1; B7; Activation B7-1 antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [5]
2 Reconstituted Complex [4]
References  Top
REF 1 Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J Immunol. 1997 Jul 1;159(1):144-51.
REF 2 A structural explanation for the recognition of tyrosine-based endocytotic signals. Science. 1998 Nov 13;282(5392):1327-32.
REF 3 Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature. 2001 Mar 29;410(6828):604-8.
REF 4 A secreted protein microarray platform for extracellular protein interaction discovery. Anal Biochem. 2012 Jan 15;420(2):127-38.
REF 5 Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28. J Biol Chem. 1995 Sep 8;270(36):21181-7.

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