Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T15441 Target Info
Target Name Ubiquitin C-terminal hydrolase UCH37 (UCHL5)
Synonyms Ubiquitin thioesterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; UCH37; UCH-L5; CGI-70; AD-019
Target Type Patented-recorded Target
Gene Name UCHL5
Biochemical Class Peptidase
UniProt ID
UCHL5_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 9 Acid anhydride hydrolases +
Interacting Protein Name Proteasome 26S subunit ATPase 6 (PSMC6) Interacting Protein Interacting Protein Info
UniProt ID
PRS10_HUMAN 
Synonyms CADP44; HEL.S.73; P44; SUG2; p42
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
Interacting Protein Name Proteasome 26S subunit ATPase 1 (PSMC1) Interacting Protein Interacting Protein Info
UniProt ID
PRS4_HUMAN 
Synonyms P26S4; S4; p56
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
Interacting Protein Name Proteasome 26S subunit ATPase 4 (PSMC4) Interacting Protein Interacting Protein Info
UniProt ID
PRS6B_HUMAN 
Synonyms MIP224; RPT3; S6; TBP.7; TBP7
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
Interacting Protein Name Proteasome 26S subunit ATPase 2 (PSMC2) Interacting Protein Interacting Protein Info
UniProt ID
PRS7_HUMAN 
Synonyms MSS1; Nbla10058; S7
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
Interacting Protein Name Proteasome 26S subunit ATPase 5 (PSMC5) Interacting Protein Interacting Protein Info
UniProt ID
PRS8_HUMAN 
Synonyms S8; SUG.1; SUG1; TBP10; TRIP1; p45; p45/SUG
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
Interacting Protein Name Chromatin-remodeling ATPase INO80 (INO80) Interacting Protein Interacting Protein Info
UniProt ID
INO80_HUMAN 
Synonyms INO80A; INOC1; hINO80
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Co-fractionation [6]
Interacting Protein Name Proteasome 26S subunit ATPase 3 (PSMC3) Interacting Protein Interacting Protein Info
UniProt ID
PRS6A_HUMAN 
Synonyms TBP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
Interacting Protein Name RuvB-like 1 (RUVBL1) Interacting Protein Interacting Protein Info
UniProt ID
RUVB1_HUMAN 
Synonyms ECP54; INO80H; NMP238; PONTIN; Pontin52; RVB1; TIH1; TIP49; TIP49A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
Interacting Protein Name RuvB-like 2 (RUVBL2) Interacting Protein Interacting Protein Info
UniProt ID
RUVB2_HUMAN 
Synonyms ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
Actins [+] 2 Actins +
Interacting Protein Name Actin-related protein 5 (ACTR5) Interacting Protein Interacting Protein Info
UniProt ID
ARP5_HUMAN 
Synonyms Arp5; INO80M
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Actin-related protein 8 (ACTR8) Interacting Protein Interacting Protein Info
UniProt ID
ARP8_HUMAN 
Synonyms ARP8; INO80N; hArp8
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Renal carcinoma antigen NY-REN-54 (UBE3A) Literature-reported Target Interacting Protein Info
UniProt ID
UBE3A_HUMAN 
Synonyms Ubiquitin-protein ligase E3A; Oncogenic protein-associated protein E6-AP; Human papillomavirus E6-associated protein; HPVE6A; HECT-type ubiquitin transferase E3A; EPVE6AP; E6AP ubiquitin-protein ligase; E6AP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Biochemical Activity [8]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name Nitric-oxide synthase inducible (NOS2) Clinical trial Target Interacting Protein Info
UniProt ID
NOS2_HUMAN 
Synonyms Peptidyl-cysteine S-nitrosylase NOS2; NOS2A; NOS, type II; NOS type II; Nitric oxide synthase, inducible; INOS; Inducible NOS; Inducible NO synthase; Inducible nitric oxide synthase; HEP-NOS; Hepatocyte NOS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
Peptidases [+] 14 Peptidases +
Interacting Protein Name Proteasome 26S subunit non-ATPase 14 (PSMD14) Interacting Protein Interacting Protein Info
UniProt ID
PSDE_HUMAN 
Synonyms PAD1; POH1; RPN11
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
Interacting Target Name Proteasome beta-5 (PS beta-5) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB5_HUMAN 
Synonyms Proteasome subunit X; Proteasome subunit MB1; Proteasome subunit beta type-5; Proteasome epsilon chain; Proteasome chain 6; Multicatalytic endopeptidase complex epsilon chain; MB1; Macropain epsilon chain; LMPX
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Co-fractionation [11]
Interacting Target Name Proteasome beta-1 (PS beta-1) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB6_HUMAN 
Synonyms Proteasome subunit Y; Proteasome subunit beta type-6; Proteasome delta chain; Multicatalytic endopeptidase complex delta chain; Macropain delta chain; LMPY
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Co-fractionation [11]
Interacting Protein Name Proteasome subunit beta type-3 (PSMB3) Interacting Protein Interacting Protein Info
UniProt ID
PSB3_HUMAN 
Synonyms HC10.II
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Co-fractionation [11]
Interacting Protein Name Proteasome 26S subunit non-ATPase 7 (PSMD7) Interacting Protein Interacting Protein Info
UniProt ID
PSMD7_HUMAN 
Synonyms MOV34; P40; Rpn8; S12
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Co-fractionation [5]
Interacting Target Name Proteasome beta-2 (PS beta-2) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB7_HUMAN 
Synonyms Proteasome subunit Z; Proteasome subunit beta type-7; Multicatalytic endopeptidase complex chain Z; Macropain chain Z
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [11]
Interacting Protein Name Proteasome subunit alpha type-1 (PSMA1) Interacting Protein Interacting Protein Info
UniProt ID
PSA1_HUMAN 
Synonyms HC2; HEL.S.275; NU; PROS30
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [11]
Interacting Protein Name Proteasome subunit alpha type-2 (PSMA2) Interacting Protein Interacting Protein Info
UniProt ID
PSA2_HUMAN 
Synonyms HC3; MU; PMSA2; PSC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [11]
Interacting Protein Name Proteasome subunit alpha type-3 (PSMA3) Interacting Protein Interacting Protein Info
UniProt ID
PSA3_HUMAN 
Synonyms HC8; PSC3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [11]
Interacting Protein Name Proteasome subunit alpha type-4 (PSMA4) Interacting Protein Interacting Protein Info
UniProt ID
PSA4_HUMAN 
Synonyms HC9; HsT17706; PSC9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [11]
Interacting Protein Name Proteasome subunit alpha type-5 (PSMA5) Interacting Protein Interacting Protein Info
UniProt ID
PSA5_HUMAN 
Synonyms PSC5; ZETA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [11]
Interacting Protein Name Proteasome subunit alpha type-7 (PSMA7) Interacting Protein Interacting Protein Info
UniProt ID
PSA7_HUMAN 
Synonyms C6; HSPC; RC6.1; XAPC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [11]
Interacting Protein Name Proteasome subunit beta type-2 (PSMB2) Interacting Protein Interacting Protein Info
UniProt ID
PSB2_HUMAN 
Synonyms HC7.I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [11]
Interacting Protein Name Proteasome subunit beta type-4 (PSMB4) Interacting Protein Interacting Protein Info
UniProt ID
PSB4_HUMAN 
Synonyms HN3; HsN3; PROS.26; PROS26
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [11]
Proteasome components [+] 10 Proteasome components +
Interacting Protein Name Proteasomal ubiquitin receptor ADRM1 (ADRM1) Interacting Protein Interacting Protein Info
UniProt ID
ADRM1_HUMAN 
Synonyms ARM.1; ARM1; GP110
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Affinity Capture-Western [12]
6 Affinity Capture-Western [13]
7 Co-crystal Structure [14]
8 Co-crystal Structure [15]
9 Co-fractionation [12]
10 Co-fractionation [11]
11 Co-fractionation [5]
12 Co-purification [15]
13 Reconstituted Complex [12]
14 Reconstituted Complex [4]
15 Reconstituted Complex [13]
16 Reconstituted Complex [14]
17 Reconstituted Complex [16]
18 Reconstituted Complex [6]
19 Yeast two hybrid [17]
20 Yeast two hybrid [18]
Interacting Protein Name Proteasome 26S subunit non-ATPase 1 (PSMD1) Interacting Protein Interacting Protein Info
UniProt ID
PSMD1_HUMAN 
Synonyms P112; Rpn2; S1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
6 Co-fractionation [11]
Interacting Protein Name Tumor necrosis factor type 1 receptor-associated protein 2 (PSMD2) Interacting Protein Interacting Protein Info
UniProt ID
PSMD2_HUMAN 
Synonyms P97; RPN1; S2; TRAP2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Affinity Capture-Western [12]
6 Co-fractionation [5]
Interacting Protein Name Proteasome 26S subunit non-ATPase 4 (PSMD4) Interacting Protein Interacting Protein Info
UniProt ID
PSMD4_HUMAN 
Synonyms AF; AF.1; ASF; MCB1; Rpn10; S5A; pUB.R5
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
6 Reconstituted Complex [16]
Interacting Protein Name Proteasome 26S subunit non-ATPase 11 (PSMD11) Interacting Protein Interacting Protein Info
UniProt ID
PSD11_HUMAN 
Synonyms Rpn6; S9; p44.5
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
Interacting Protein Name Proteasome 26S subunit non-ATPase 3 (PSMD3) Interacting Protein Interacting Protein Info
UniProt ID
PSMD3_HUMAN 
Synonyms P58; RPN3; S3; TSTA2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
Interacting Protein Name Proteasome 26S subunit non-ATPase 8 (PSMD8) Interacting Protein Interacting Protein Info
UniProt ID
PSMD8_HUMAN 
Synonyms HEL.S.91n; HIP6; HYPF; Nin1p; Rpn12; S14; p31
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Co-fractionation [5]
4 Reconstituted Complex [19]
5 Yeast two hybrid [19]
Interacting Protein Name Proteasome 26S subunit non-ATPase 12 (PSMD12) Interacting Protein Interacting Protein Info
UniProt ID
PSD12_HUMAN 
Synonyms Rpn5; p55
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
Interacting Protein Name Proteasome 26S subunit non-ATPase 13 (PSMD13) Interacting Protein Interacting Protein Info
UniProt ID
PSD13_HUMAN 
Synonyms HSPC027; Rpn9; S11; p40.5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
Interacting Protein Name Proteasome 26S subunit non-ATPase 6 (PSMD6) Interacting Protein Interacting Protein Info
UniProt ID
PSMD6_HUMAN 
Synonyms Rpn7; S10; SGA.113M; p42A; p44S10
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Microspherule protein 1 (MCRS1) Interacting Protein Interacting Protein Info
UniProt ID
MCRS1_HUMAN 
Synonyms ICP22BP; INO80Q; MCRS2; MSP58; P78
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Transcriptional repressor protein YY1 (YY1) Interacting Protein Interacting Protein Info
UniProt ID
TYY1_HUMAN 
Synonyms DELTA; INO80S; NF.E1; UCRBP; YIN.YANG.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Reconstituted Complex [21]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 6 Experimental Evidences +
1 Biochemical Activity [22]
2 Biochemical Activity [23]
3 Biochemical Activity [24]
4 Co-crystal Structure [24]
5 Reconstituted Complex [15]
6 Reconstituted Complex [24]
Other proteins [+] 5 Other proteins +
Interacting Protein Name Nuclear factor related to kappa-B-binding protein (NFRKB) Interacting Protein Interacting Protein Info
UniProt ID
NFRKB_HUMAN 
Synonyms INO80G
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-crystal Structure [15]
6 Co-crystal Structure [25]
7 Co-purification [15]
8 Reconstituted Complex [4]
9 Yeast two hybrid [4]
Interacting Protein Name INO80 complex subunit B (INO80B) Interacting Protein Interacting Protein Info
UniProt ID
IN80B_HUMAN 
Synonyms HMGA1L4; HMGIYL4; IES2; PAP.1BP; PAPA.1; ZNHIT4; hIes2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [4]
Interacting Protein Name INO80 complex subunit E (INO80E) Interacting Protein Interacting Protein Info
UniProt ID
IN80E_HUMAN 
Synonyms CCDC95
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
Interacting Protein Name TCF3 fusion partner (TFPT) Interacting Protein Interacting Protein Info
UniProt ID
TFPT_HUMAN 
Synonyms FB1; INO80F; amida
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
Interacting Protein Name INO80 complex subunit C (INO80C) Interacting Protein Interacting Protein Info
UniProt ID
IN80C_HUMAN 
Synonyms C18orf37; IES6; hIes6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
References  Top
REF 1 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 4 Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Mol Cell. 2008 Sep 26;31(6):909-17.
REF 5 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 6 Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets. Nat Commun. 2017 Jun 9;8:15540.
REF 7 Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Mol Cell Biol. 2012 Aug;32(15):3095-106.
REF 8 Autoregulation of the 26S proteasome by in situ ubiquitination. Mol Biol Cell. 2014 Jun 15;25(12):1824-35.
REF 9 Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Nitric Oxide. 2013 Nov 1;34:37-46.
REF 10 Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13). Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13854-9.
REF 11 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 12 A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. EMBO J. 2006 Oct 4;25(19):4524-36.
REF 13 Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol. 2006 Sep;8(9):994-1002.
REF 14 Mechanism of the Rpn13-induced activation of Uch37. Protein Cell. 2014;5(8):616-30.
REF 15 Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G. Mol Cell. 2015 Mar 5;57(5):887-900.
REF 16 hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J. 2006 Dec 13;25(24):5742-53.
REF 17 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.
REF 18 rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Nat Commun. 2018 Sep 14;9(1):3747.
REF 19 Identification of two proteins, S14 and UIP1, that interact with UCH37. FEBS Lett. 2001 Jan 19;488(3):201-5.
REF 20 Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGF-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis. Sci Rep. 2016 Sep 8;6:33116.
REF 21 The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling. Oncogene. 2005 Dec 1;24(54):8080-4.
REF 22 Contribution of active site glutamine to rate enhancement in ubiquitin C-terminal hydrolases. FEBS J. 2012 Mar;279(6):1106-18.
REF 23 Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem Biol. 2016 Apr 21;23(4):472-82.
REF 24 Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome. Sci Rep. 2017 Mar 24;7:45174.
REF 25 Structural basis for the activation and inhibition of the UCH37 deubiquitylase. Mol Cell. 2015 Mar 5;57(5):901-911.

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