Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T16739 Target Info
Target Name Lysine-specific histone demethylase 1 (LSD)
Synonyms Lysine-specific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; BRAF35-HDAC complex protein BHC110; AOF2
Target Type Clinical trial Target
Gene Name KDM1A
Biochemical Class CH-NH(2) donor oxidoreductase
UniProt ID
KDM1A_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RNF168 (RNF168) Interacting Protein Interacting Protein Info
UniProt ID
RN168_HUMAN 
Synonyms hRNF168
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [2]
Carbon-nitrogen hydrolases [+] 3 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-MS [6]
5 Affinity Capture-Western [7]
6 Affinity Capture-Western [8]
7 Affinity Capture-Western [9]
8 Affinity Capture-Western [10]
9 Affinity Capture-Western [11]
10 Affinity Capture-Western [12]
11 Affinity Capture-Western [13]
12 Affinity Capture-Western [14]
13 Affinity Capture-Western [15]
14 Co-fractionation [16]
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [6]
4 Affinity Capture-Western [3]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [12]
8 Affinity Capture-Western [13]
9 Affinity Capture-Western [15]
10 Affinity Capture-Western [17]
11 Co-fractionation [16]
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Histones [+] 2 Histones +
Interacting Protein Name Histone H3.1 (H31) Interacting Protein Interacting Protein Info
UniProt ID
H31_HUMAN 
Synonyms H3/A; H3FA
Evidence Score (E-score) 6 Experimental Evidences +
1 Biochemical Activity [18]
2 Biochemical Activity [5]
3 Biochemical Activity [6]
4 Biochemical Activity [19]
5 Biochemical Activity [20]
6 Protein-peptide [21]
Interacting Protein Name Histone H3.2 (H32) Interacting Protein Interacting Protein Info
UniProt ID
H32_HUMAN 
Synonyms H3; H3.2; H3/M; H3F2; H3FM; H3FN
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [22]
2 Co-crystal Structure [23]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Proximity Label-MS [25]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Affinity Capture-Western [27]
3 Biochemical Activity [27]
4 Reconstituted Complex [26]
5 Reconstituted Complex [27]
Transcription regulators [+] 6 Transcription regulators +
Interacting Protein Name REST corepressor 1 (RCOR1) Interacting Protein Interacting Protein Info
UniProt ID
RCOR1_HUMAN 
Synonyms COREST; RCOR
Evidence Score (E-score) 17 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [28]
3 Affinity Capture-MS [4]
4 Affinity Capture-MS [6]
5 Affinity Capture-Western [17]
6 Affinity Capture-Western [8]
7 Affinity Capture-Western [9]
8 Affinity Capture-Western [10]
9 Affinity Capture-Western [14]
10 Affinity Capture-Western [15]
11 Affinity Capture-Western [20]
12 Affinity Capture-Western [29]
13 Affinity Capture-Western [1]
14 Co-crystal Structure [30]
15 Co-fractionation [16]
16 Reconstituted Complex [5]
17 Reconstituted Complex [31]
Interacting Protein Name SMARCE1-related protein (HMG20B) Interacting Protein Interacting Protein Info
UniProt ID
HM20B_HUMAN 
Synonyms BRAF25; BRAF35; HMGX2; HMGXB2; PP7706; SMARCE1r; SOXL; pp8857
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-MS [6]
5 Affinity Capture-Western [32]
Interacting Protein Name PHD finger protein 21A (PHF21A) Interacting Protein Interacting Protein Info
UniProt ID
PF21A_HUMAN 
Synonyms BHC80
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [28]
3 Affinity Capture-MS [5]
4 Affinity Capture-MS [6]
5 Reconstituted Complex [33]
Interacting Target Name Metastasis associated gene-1 (MTA1) Literature-reported Target Interacting Protein Info
UniProt ID
MTA1_HUMAN 
Synonyms Metastasis-associated protein MTA1; Metastasisassociated protein MTA1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [8]
3 Reconstituted Complex [13]
Interacting Protein Name REST corepressor 3 (RCOR3) Interacting Protein Interacting Protein Info
UniProt ID
RCOR3_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [16]
Interacting Protein Name Zinc finger protein 217 (ZNF217) Interacting Protein Interacting Protein Info
UniProt ID
ZN217_HUMAN 
Synonyms Zinc finger protein 217; ZABC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [34]
2 Affinity Capture-Western [35]
Other proteins [+] 3 Other proteins +
Interacting Protein Name Metastasis-associated protein MTA2 (MTA2) Interacting Protein Interacting Protein Info
UniProt ID
MTA2_HUMAN 
Synonyms MTA1L1; PID
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [12]
4 Reconstituted Complex [13]
Interacting Protein Name Metastasis-associated protein MTA3 (MTA3) Interacting Protein Interacting Protein Info
UniProt ID
MTA3_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [13]
Interacting Protein Name YEATS domain-containing protein 4 (YEATS4) Interacting Protein Interacting Protein Info
UniProt ID
YETS4_HUMAN 
Synonyms 4930573H17Rik; B230215M10Rik; GAS41; NUBI.1; YAF9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [28]
2 Yeast two hybrid [36]
References  Top
REF 1 The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol. 2013 Nov 11;203(3):457-70.
REF 2 Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage. Nucleic Acids Res. 2015 Jul 13;43(12):5936-47.
REF 3 A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem. 2003 Feb 28;278(9):7234-9.
REF 4 Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011 Mar;29(3):255-65.
REF 5 Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell. 2005 Sep 16;19(6):857-64.
REF 6 An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature. 2005 Sep 15;437(7057):432-5.
REF 7 Dynamic regulation of histone H3 methylation at lysine 4 in mammalian spermatogenesis. Biol Reprod. 2007 Nov;77(5):754-64.
REF 8 Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic -type globin promoters in differentiated adult erythroid cells. Mol Cell Biol. 2011 Aug;31(16):3298-311.
REF 9 Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J Biol Chem. 2001 Mar 2;276(9):6817-24.
REF 10 CoREST is an integral component of the CoREST- human histone deacetylase complex. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1454-8.
REF 11 Epigenetic mechanisms regulate stem cell expressed genes Pou5f1 and Gfra1 in a male germ cell line. PLoS One. 2010 Sep 14;5(9):e12727.
REF 12 Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. Cancer Res. 2011 Nov 1;71(21):6899-908.
REF 13 LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell. 2009 Aug 21;138(4):660-72.
REF 14 Defective heart development in hypomorphic LSD1 mice. Cell Res. 2011 Dec 6. doi: 10.1038/cr.2011.194.
REF 15 LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B. Cancer Res. 2017 Sep 1;77(17):4652-4662.
REF 16 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 17 Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system. J Neurosci. 2010 Feb 17;30(7):2521-32.
REF 18 Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61.
REF 19 Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature. 2010 Apr 1;464(7289):792-6.
REF 20 The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J. 2010 Jun 2;29(11):1803-16.
REF 21 Human histone demethylase LSD1 reads the histone code. J Biol Chem. 2005 Dec 16;280(50):41360-5.
REF 22 Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004 Dec 29;119(7):941-53.
REF 23 Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature. 2007 Aug 9;448(7154):718-22.
REF 24 CACUL1 functions as a negative regulator of androgen receptor in prostate cancer cells. Cancer Lett. 2016 Jul 1;376(2):360-6.
REF 25 Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Mol Cell Proteomics. 2017 Aug;16(8):1462-1474.
REF 26 p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol. 2008 Sep;28(17):5139-46.
REF 27 p53 is regulated by the lysine demethylase LSD1. Nature. 2007 Sep 6;449(7158):105-8.
REF 28 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491.
REF 29 LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Nat Cell Biol. 2011 Jun;13(6):652-9.
REF 30 Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell. 2006 Aug 4;23(3):377-87.
REF 31 Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST. Biochemistry. 2011 Feb 1;50(4):546-57.
REF 32 A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7420-5.
REF 33 Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression. Biochem Biophys Res Commun. 2004 Sep 17;322(2):601-8.
REF 34 The ZNF217 oncogene is a candidate organizer of repressive histone modifiers. Epigenetics. 2009 Feb 16;4(2):100-6.
REF 35 Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. Mol Cell Biol. 2008 Oct;28(19):6066-77.
REF 36 Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours. Acta Biochim Pol. 2011;58(4):529-34.

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