Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T17048 Target Info
Target Name DNA topoisomerase II alpha (TOP2A)
Synonyms DNA topoisomerase II, alpha isozyme; DNA topoisomerase 2alpha; DNA topoisomerase 2-alpha
Target Type Clinical trial Target
Gene Name TOP2A
Biochemical Class Topoisomerase
UniProt ID
TOP2A_HUMAN 
Target Interacting Proteins  Top
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Isomerases [+] 1 Isomerases +
Interacting Target Name DNA topoisomerase II beta (TOP2B) Successful Target Interacting Protein Info
UniProt ID
TOP2B_HUMAN 
Synonyms Topo IIbeta; TOP2beta; TOP2B
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [3]
2 Reconstituted Complex [4]
Kinases [+] 1 Kinases +
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Co-fractionation [6]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Yeast two hybrid [8]
Other proteins [+] 1 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [9]
References  Top
REF 1 Histone deacetylase interacts directly with DNA topoisomerase II. Nat Genet. 2000 Nov;26(3):349-53.
REF 2 Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. J Biol Chem. 2001 Feb 16;276(7):4539-42.
REF 3 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 4 Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8288-93.
REF 5 A bead-based approach for large-scale identification of in vitro kinase substrates. Proteomics. 2011 Dec;11(24):4632-7.
REF 6 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 7 Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase II degradation in hepatocellular carcinoma cells. Hepatology. 2011 Jan;53(1):148-59.
REF 8 Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5. J Biol Chem. 2004 Jul 23;279(30):31296-303.
REF 9 Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. Gastroenterology. 2005 Oct;129(4):1225-36.

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