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| Target General Information |
Top |
| Target ID |
T17758 |
Target Info
|
| Target Name |
Urokinase-type plasminogen activator (PLAU) |
| Synonyms |
UPA; U-plasminogen activator |
| Target Type |
Successful Target |
| Gene Name |
PLAU |
| Biochemical Class |
Peptidase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Other proteins |
[+] 2 Other proteins |
+ |
| Interacting Protein Name |
Glia-derived nexin (SERPINE2) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
GDN; GDNPF; PI.7; PI7; PN.1; PN1; PNI |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-MS |
[2] |
| 3 |
Reconstituted Complex |
[3] |
| Interacting Target Name |
Urokinase plasminogen activator surface receptor (PLAUR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Urokinase-type plasminogen activator receptor; Urokinase plasminogen activator receptor; U-PAR; UPAR; Monocyte activation antigenMo3; Monocyte activation antigen Mo3; MO3; CD87 antigen; CD87 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[4] |
| 2 |
Reconstituted Complex |
[5] |
| References |
Top |
| REF 1 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
|
| REF 2 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
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| REF 3 |
Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J. 1997 May 15;16(10):2610-20.
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| REF 4 |
A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis. J Cell Mol Med. 2009 Sep;13(9B):4034-41.
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| REF 5 |
Ligand binding regions in the receptor for urokinase-type plasminogen activator. J Biol Chem. 2001 Aug 3;276(31):28946-53.
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