Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T20178 Target Info
Target Name Tumor necrosis factor (TNF)
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; TNFalpha; TNFSF2; TNFA; TNF-alpha; TNF-a; TNF alpha; Cachectin
Target Type Successful Target
Gene Name TNF
Biochemical Class Cytokine: tumor necrosis factor
UniProt ID
TNFA_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 5 Acyltransferases +
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
Interacting Target Name Linear ubiquitin chain assembly complex (RBCK1) Literature-reported Target Interacting Protein Info
UniProt ID
HOIL1_HUMAN 
Synonyms XAP4; XAP3; Ubiquitin-conjugating enzyme 7-interacting protein 3; UBCE7IP3; RNF54; RING-type E3 ubiquitin transferase HOIL-1; RING finger protein 54; RanBP-type and C3HC4-type zinc finger-containing protein 1; HOIL-1; Hepatitis B virus X-associated protein 4; Heme-oxidized IRP2 ubiquitin ligase 1; HBV-associated factor 4; C20orf18
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [6]
Interacting Protein Name E3 ubiquitin-protein ligase RNF31 (RNF31) Interacting Protein Interacting Protein Info
UniProt ID
RNF31_HUMAN 
Synonyms HOIP; ZIBRA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [2]
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [7]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) Interacting Protein Interacting Protein Info
UniProt ID
TAB2_HUMAN 
Synonyms CHTD2; MAP3K7IP2; TAB.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [8]
Kinases [+] 5 Kinases +
Interacting Target Name Receptor-interacting protein 1 (RIPK1) Clinical trial Target Interacting Protein Info
UniProt ID
RIPK1_HUMAN 
Synonyms RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [10]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [8]
Interacting Target Name NF-kappa-B-activating kinase (TBK1) Patented-recorded Target Interacting Protein Info
UniProt ID
TBK1_HUMAN 
Synonyms TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [1]
Interacting Target Name TGF-beta-activated kinase 1 (MAP3K7) Literature-reported Target Interacting Protein Info
UniProt ID
M3K7_HUMAN 
Synonyms Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [8]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Peptidases [+] 2 Peptidases +
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) Interacting Protein Interacting Protein Info
UniProt ID
CYLD_HUMAN 
Synonyms BRSS; CDMT; CYLD1; CYLDI; EAC; MFT; MFT1; SBS; TEM; USPL2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [11]
Interacting Protein Name Ubiquitin thioesterase otulin (OTULIN) Interacting Protein Interacting Protein Info
UniProt ID
OTUL_HUMAN 
Synonyms FAM105B; GUM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [12]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [13]
Other proteins [+] 9 Other proteins +
Interacting Target Name Tumor necrosis factor receptor type I (TNF-R1) Clinical trial Target Interacting Protein Info
UniProt ID
TNR1A_HUMAN 
Synonyms Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-RI; TNFR-I; TNFR1; TNFAR; TBPI; p60; p55; CD120a
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [3]
Interacting Protein Name TNFRSF1A-associated via death domain (TRADD) Interacting Protein Interacting Protein Info
UniProt ID
TRADD_HUMAN 
Synonyms Hs.89862
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [3]
Interacting Target Name Tumor necrosis factor receptor type II (TNF-R2) Literature-reported Target Interacting Protein Info
UniProt ID
TNR1B_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor II; Tumor necrosis factor receptor 2; TNF-RII; TNFR-II; TNFR2; TNFBR; p80 TNF-alpha receptor; P75; Etanercept; Cytokine response modifying protein B; CD120b
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Reconstituted Complex [14]
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [8]
Interacting Protein Name Optineurin (OPTN) Interacting Protein Interacting Protein Info
UniProt ID
OPTN_HUMAN 
Synonyms ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA.INTP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [15]
Interacting Protein Name Sharpin (SHARPIN) Interacting Protein Interacting Protein Info
UniProt ID
SHRPN_HUMAN 
Synonyms SIPL1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Interacting Protein Name Spermatogenesis-associated protein 2 (SPATA2) Interacting Protein Interacting Protein Info
UniProt ID
SPAT2_HUMAN 
Synonyms PD1; PPP1R145; tamo
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [16]
Interacting Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) Interacting Protein Interacting Protein Info
UniProt ID
TAB1_HUMAN 
Synonyms 3.Tab1; MAP3K7IP1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Interacting Protein Name TNFAIP3-interacting protein 1 (TNIP1) Interacting Protein Interacting Protein Info
UniProt ID
TNIP1_HUMAN 
Synonyms ABIN.1; NAF1; VAN; nip40.1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
References  Top
REF 1 SPATA2 links CYLD to the TNF- receptor signaling complex and modulates the receptor signaling outcomes. EMBO J. 2016 Sep 1;35(17):1868-84.
REF 2 Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-B regulation. EMBO J. 2012 Oct 3;31(19):3856-70.
REF 3 Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell. 2011 Nov 18;44(4):559-71.
REF 4 Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.
REF 5 The seventh zinc finger motif of A20 is required for the suppression of TNF--induced apoptosis. FEBS Lett. 2015 May 22;589(12):1369-75.
REF 6 A20 inhibits LUBAC-mediated NF-B activation by binding linear polyubiquitin chains via its zinc finger 7. EMBO J. 2012 Oct 3;31(19):3845-55.
REF 7 NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-inter... J Biol Chem. 2004 Dec 17;279(51):53266-71.
REF 8 Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell. 2006 Apr 21;22(2):245-57.
REF 9 Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity. 2003 May;18(5):655-64.
REF 10 Sam68 is required for both NF-B activation and apoptosis signaling by the TNF receptor. Mol Cell. 2011 Jul 22;43(2):167-79.
REF 11 LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes. Cell Rep. 2015 Dec 15;13(10):2258-72.
REF 12 Binding of OTULIN to the PUB domain of HOIP controls NF-B signaling. Mol Cell. 2014 May 8;54(3):349-61.
REF 13 Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1. Mol Cell Biol. 2014 Sep;34(17):3214-28.
REF 14 Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor. Diabetes. 1998 Apr;47(4):515-22.
REF 15 E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurin. PLoS One. 2012;7(6):e38348.
REF 16 SPATA2 promotes CYLD activity and regulates TNF-induced NF-B signaling and cell death. EMBO Rep. 2016 Oct;17(10):1485-1497.

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