Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20302 | Target Info | |||
| Target Name | Autophagy-related protein 7 (ATG7) | ||||
| Synonyms | hAGP7; Ubiquitin-like modifier-activating enzyme ATG7; Ubiquitin-activating enzyme E1-like protein; ATG12-activating enzyme E1 ATG7; APG7L; APG7-like | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ATG7 | ||||
| Biochemical Class | Autophagy phagophore-formation transporter | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Alpha-type channels | [+] 1 Alpha-type channels | + | |||
| Interacting Protein Name | Gamma-aminobutyric acid receptor-associated protein (GABARAP) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ATG8A; GABARAP.a; MM46 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Biochemical Activity | [2] | |||
| 3 | Reconstituted Complex | [2] | |||
| Ubiquitin related proteins | [+] 3 Ubiquitin related proteins | + | |||
| Interacting Protein Name | Ubiquitin-like-conjugating enzyme ATG3 (ATG3) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | APG3; APG3.LIKE; APG3L; PC3.96 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-MS | [1] | |||
| 3 | Affinity Capture-Western | [4] | |||
| Interacting Protein Name | Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ATG8; ATG8C; GATE.16; GATE16; GEF.2; GEF2 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Biochemical Activity | [2] | |||
| 3 | Reconstituted Complex | [2] | |||
| Interacting Protein Name | Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | APG8.LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Network organization of the human autophagy system. Nature. 2010 Jul 1;466(7302):68-76. | ||||
| REF 2 | Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem. 2006 Feb 10;281(6):3017-24. | ||||
| REF 3 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 4 | Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J Biol Chem. 2002 Apr 19;277(16):13739-44. | ||||
| REF 5 | Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3. FEBS J. 2006 Jun;273(11):2553-62. | ||||
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