Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T21580 Target Info
Target Name GTPase activating protein (RASA1)
Synonyms p120GAP; RasGAP; Ras p21 protein activator; Ras GTPase-activating protein 1; RASA; GTPase-activating protein; GAP
Target Type Literature-reported Target
Gene Name RASA1
UniProt ID
RASA1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name GTPase HRas (HRAS) Literature-reported Target Interacting Protein Info
UniProt ID
RASH_HUMAN 
Synonyms Transforming protein p21; p21ras; H-Ras-1; Ha-Ras; HaRas; GTPase HRas, Nterminally processed; GTPase HRas; c-H-ras; cHras
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Co-crystal Structure [3]
4 Reconstituted Complex [4]
5 Reconstituted Complex [1]
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name NCK adaptor protein 1 (NCK1) Clinical trial Target Interacting Protein Info
UniProt ID
NCK1_HUMAN 
Synonyms SH2/SH3 adaptor protein NCK-alpha; SH2/SH3 adaptor protein NCKalpha; Nck-1; Nck1; NCK; Cytoplasmic protein NCK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Far Western [6]
Kinases [+] 2 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [7]
2 Reconstituted Complex [8]
Interacting Target Name Focal adhesion kinase 2 (PTK2B) Literature-reported Target Interacting Protein Info
UniProt ID
FAK2_HUMAN 
Synonyms Related adhesion focal tyrosine kinase; RAFTK; PYK2; Protein-tyrosine kinase 2-beta; Proline-rich tyrosine kinase 2; FAK2; FADK 2; Cell adhesion kinase beta; Calcium-regulated non-receptor proline-rich tyrosine kinase; Calcium-dependent tyrosine kinase; CAK-beta; CAKB; CADTK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [9]
Other proteins [+] 1 Other proteins +
Interacting Target Name GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) Literature-reported Target Interacting Protein Info
UniProt ID
KHDR1_HUMAN 
Synonyms Src-associated in mitosis 68 kDa protein; Srcassociated in mitosis 68 kDa protein; Sam68; p68; p21 Ras GTPase-activating protein-associated p62; p21 Ras GTPaseactivating proteinassociated p62; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; GAPassociated tyrosine phosphoprotein p62
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [11]
3 Affinity Capture-Western [12]
4 Affinity Capture-Western [13]
5 Reconstituted Complex [14]
References  Top
REF 1 EGFR phosphorylates FAM129B to promote Ras activation. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):644-9.
REF 2 Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm. Eur J Biochem. 2001 Jun;268(11):3275-83.
REF 3 The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science. 1997 Jul 18;277(5324):333-8.
REF 4 Ras binding to a C-terminal region of GAP. FEBS Lett. 1995 Jul 17;368(2):297-303.
REF 5 Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J. 1997 Jul 1;16(13):3877-88.
REF 6 Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity. Cell Signal. 2011 Oct;23(10):1651-8.
REF 7 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
REF 8 Cloning and characterization of GRB14, a novel member of the GRB7 gene family. J Biol Chem. 1996 May 24;271(21):12502-10.
REF 9 Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. FEBS Lett. 2000 Mar 3;469(1):88-92.
REF 10 Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling. Mol Cell Endocrinol. 2001 Oct 25;183(1-2):113-21.
REF 11 Sam68 association with p120GAP in CD4+ T cells is dependent on CD4 molecule expression. J Immunol. 1998 Sep 15;161(6):2798-803.
REF 12 Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins. J Immunol. 1993 Jan 15;150(2):377-86.
REF 13 Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein. J Immunol. 1994 Jun 1;152(11):5429-37.
REF 14 Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor recept... J Biol Chem. 1992 Nov 15;267(32):22779-86.

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