Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T22547 Target Info
Target Name Proto-oncogene c-Rel (REL)
Synonyms C-Rel
Target Type Literature-reported Target
Gene Name REL
UniProt ID
REL_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [1]
4 Reconstituted Complex [2]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Syntenin-1 (SDCBP) Interacting Protein Interacting Protein Info
UniProt ID
SDCB1_HUMAN 
Synonyms MDA.9; MDA9; ST1; SYCL; TACIP18
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [4]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [7]
4 Affinity Capture-MS [3]
5 Reconstituted Complex [8]
6 Reconstituted Complex [9]
7 Yeast two hybrid [9]
8 Yeast two hybrid [4]
Interacting Target Name Nuclear factor NF-kappa-B (NFKB) Successful Target Interacting Protein Info
UniProt ID
NFKB2_HUMAN 
Synonyms Oncogene Lyt-10; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Nuclear factor NF-kappa-Bp52 subunit; Nuclear factor NF-kappa-B p100 subunit; Lyt10; Lymphocyte translocation chromosome 10 protein; Lymphocyte translocation chromosome 10; H2TF1; DNA-binding factor KBF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [10]
Other proteins [+] 3 Other proteins +
Interacting Protein Name NF-kappa-B inhibitor epsilon (NFKBIE) Interacting Protein Interacting Protein Info
UniProt ID
IKBE_HUMAN 
Synonyms IKBE
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [11]
5 Reconstituted Complex [12]
Interacting Protein Name NF-kappa-B inhibitor alpha (NFKBIA) Interacting Protein Interacting Protein Info
UniProt ID
IKBA_HUMAN 
Synonyms IKBA; MAD.3; NFKBI
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [11]
3 Affinity Capture-Western [13]
Interacting Protein Name NF-kappa-B inhibitor beta (NFKBIB) Interacting Protein Interacting Protein Info
UniProt ID
IKBB_HUMAN 
Synonyms IKBB; TRIP9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [11]
3 Affinity Capture-Western [13]
References  Top
REF 1 Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8. Cancer Lett. 2010 May 28;291(2):237-45.
REF 2 Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth. Mol Cancer. 2014 Feb 15;13:29.
REF 3 TNIP2 is a Hub Protein in the NF-B Network with Both Protein and RNA Mediated Interactions. Mol Cell Proteomics. 2016 Nov;15(11):3435-3449.
REF 4 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 7 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 2004 Feb;6(2):97-105.
REF 8 Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription. Mol Cell Biol. 1994 Apr;14(4):2593-603.
REF 9 Mutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformation. J Virol. 2002 May;76(10):4928-39.
REF 10 NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule. Mol Cell Biol. 1993 Oct;13(10):6089-101.
REF 11 A functional role of I kappa B-epsilon in endothelial cell activation. J Immunol. 2000 Mar 15;164(6):3316-22.
REF 12 I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8962-6.
REF 13 Basal phosphorylation of the PEST domain in the I(kappa)B(beta) regulates its functional interaction with the c-rel proto-oncogene product. Mol Cell Biol. 1996 Nov;16(11):5974-84.

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