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| Target General Information |
Top |
| Target ID |
T23348 |
Target Info
|
| Target Name |
von Willebrand factor (VWF) |
| Synonyms |
vWF; F8VWF |
| Target Type |
Successful Target |
| Gene Name |
VWF |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Other proteins |
[+] 1 Other proteins |
+ |
| Interacting Target Name |
Platelet glycoprotein Ib alpha (CD42b) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Platelet glycoprotein Ib alpha chain; GPIb-alpha; GPIbalpha; GPIbA; GP-Ib alpha; GPIb alpha; Glycoprotein Ibalpha; Glycocalicin; Antigen CD42b-alpha; Antigen CD42balpha |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Co-crystal Structure |
[1] |
| 2 |
Far Western |
[2] |
| 3 |
Reconstituted Complex |
[3] |
| References |
Top |
| REF 1 |
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science. 2002 Aug 16;297(5584):1176-9.
|
| REF 2 |
Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome. J Clin Invest. 1993 Sep;92(3):1213-20.
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| REF 3 |
Cross-linking of a monomeric 39/34-kDa dispase fragment of von Willebrand factor (Leu-480/Val-481-Gly-718) to the N-terminal region of the alpha-chain of membrane glycoprotein Ib on intact platelets with bis(sulfosuccinimidyl) suberate. Biochemistry. 1989 Oct 17;28(21):8326-36.
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