Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T26774 Target Info
Target Name Nuclear receptor coactivator 3 (NCOA3)
Synonyms bHLHe42; Thyroid hormone receptor activator molecule 1; TRAM1; TRAM-1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC3; RAC-3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB1; AIB-1; ACTR
Target Type Literature-reported Target
Gene Name NCOA3
Biochemical Class Acyltransferase
UniProt ID
NCOA3_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Co-crystal Structure [3]
4 Co-localization [4]
5 Reconstituted Complex [3]
6 Reconstituted Complex [5]
7 Reconstituted Complex [6]
8 Yeast two hybrid [7]
Kinases [+] 2 Kinases +
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [9]
4 Co-fractionation [9]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [9]
Nuclear hormone receptors [+] 10 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [12]
5 Reconstituted Complex [13]
6 Reconstituted Complex [14]
7 Yeast two hybrid [15]
8 Yeast two hybrid [11]
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Protein-peptide [17]
3 Proximity Label-MS [18]
4 Reconstituted Complex [19]
Interacting Target Name Vitamin D3 receptor (VDR) Successful Target Interacting Protein Info
UniProt ID
VDR_HUMAN 
Synonyms Vitamin D(3) receptor; Nuclear vitamin D receptor; Nuclear receptor subfamily 1 group I member 1; NR1I1; 1,25-dihydroxyvitamin D3 receptor
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Co-localization [21]
3 Reconstituted Complex [22]
4 Yeast two hybrid [23]
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Reconstituted Complex [25]
3 Yeast two hybrid [25]
Interacting Target Name Estrogen receptor beta (ESR2) Successful Target Interacting Protein Info
UniProt ID
ESR2_HUMAN 
Synonyms Oestrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; NR3A2; ESTRB; ER-beta; Erbeta; Beta-1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [13]
3 Reconstituted Complex [26]
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 3 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [27]
2 Protein-peptide [28]
3 Reconstituted Complex [29]
Interacting Target Name Thyroid hormone receptor beta (THRB) Successful Target Interacting Protein Info
UniProt ID
THB_HUMAN 
Synonyms Thyroid hormone receptor beta; THR1; Nuclear receptor subfamily 1 group A member 2; NR1A2; ERBA2; c-erbA-beta; c-erbA-2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Reconstituted Complex [31]
3 Yeast two hybrid [32]
Interacting Target Name Retinoic acid receptor alpha (RARA) Clinical trial Target Interacting Protein Info
UniProt ID
RARA_HUMAN 
Synonyms RAR-alpha; RAR alpha; Nuclear receptor subfamily 1 group B member 1; NR1B1
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [33]
2 Yeast two hybrid [33]
3 Yeast two hybrid [32]
Interacting Target Name Estrogen-related receptor-alpha (ESRRA) Successful Target Interacting Protein Info
UniProt ID
ERR1_HUMAN 
Synonyms Nuclear receptor subfamily 3 group B member 1; NR3B1; Estrogen-relatedreceptor, alpha; Estrogen-relatedreceptor alpha; Estrogen-related receptor alpha; Estrogen receptor-like 1; ESRL1; ERR-alpha; ERRalpha; ERR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [34]
2 Yeast two hybrid [32]
Interacting Target Name Retinoic acid receptor RXR-alpha (RXRA) Successful Target Interacting Protein Info
UniProt ID
RXRA_HUMAN 
Synonyms RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [35]
2 Reconstituted Complex [36]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name Histone-arginine methyltransferase CARM1 (CARM1) Literature-reported Target Interacting Protein Info
UniProt ID
CARM1_HUMAN 
Synonyms Protein arginine N-methyltransferase 4; PRMT4; Histonearginine methyltransferase CARM1; Coactivator-associated arginine methyltransferase 1; Coactivatorassociated arginine methyltransferase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Co-fractionation [37]
3 Co-purification [37]
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [38]
3 Affinity Capture-Western [39]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [40]
6 Co-fractionation [37]
7 Co-fractionation [9]
8 Co-purification [37]
9 Reconstituted Complex [31]
10 Yeast two hybrid [41]
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Co-localization [43]
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [44]
Other proteins [+] 3 Other proteins +
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [9]
4 Co-fractionation [9]
Interacting Protein Name Speckle-type POZ protein (SPOP) Interacting Protein Interacting Protein Info
UniProt ID
SPOP_HUMAN 
Synonyms BTBD32; TEF2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Affinity Capture-Western [46]
3 Reconstituted Complex [45]
4 Yeast two hybrid [45]
Interacting Protein Name Proteasome activator complex subunit 3 (PSME3) Interacting Protein Interacting Protein Info
UniProt ID
PSME3_HUMAN 
Synonyms HEL.S.283; Ki; PA28.gamma; PA28G; PA28gamma; REG.GAMMA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [47]
3 Affinity Capture-Western [47]
References  Top
REF 1 CBP/p300 interact with and function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1020-5.
REF 2 Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol Cell Biol. 2006 Nov;26(21):7846-57.
REF 3 Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature. 2002 Jan 31;415(6871):549-53.
REF 4 Roles of coactivators in hypoxic induction of the erythropoietin gene. PLoS One. 2010 Apr 2;5(4):e10002.
REF 5 Structure of a biologically active estrogen receptor-coactivator complex on DNA. Mol Cell. 2015 Mar 19;57(6):1047-1058.
REF 6 AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol Cell Biol. 2000 Jul;20(14):5041-7.
REF 7 Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). Mol Cell Biol. 2005 Nov;25(21):9687-99.
REF 8 Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol. 2005 Oct;19(10):2451-65.
REF 9 Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol. 2002 May;22(10):3549-61.
REF 10 Global characterization of transcriptional impact of the SRC-3 coregulator. Mol Endocrinol. 2010 Apr;24(4):859-72.
REF 11 Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma. Cancer Res. 2009 Jun 15;69(12):5186-93.
REF 12 Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence. Endocr Relat Cancer. 2006 Dec;13(4):1135-45.
REF 13 Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands. Biochemistry. 2001 Jun 12;40(23):6756-65.
REF 14 Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell. 1999 Sep 3;98(5):675-86.
REF 15 Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment. J Mol Endocrinol. 2004 Feb;32(1):307-23.
REF 16 BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. Mol Cell Biol. 2003 Sep;23(17):6210-20.
REF 17 Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol. Mol Cell Biol. 2008 Mar;28(6):1915-23.
REF 18 Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Mol Cell Proteomics. 2017 Aug;16(8):1462-1474.
REF 19 Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140. Mol Endocrinol. 2001 Apr;15(4):501-11.
REF 20 Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor. Mol Cell Biol. 2010 Oct;30(20):4890-900.
REF 21 Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3. J Mol Biol. 2005 Jul 1;350(1):65-77.
REF 22 Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. J Biol Chem. 2005 Jul 15;280(28):26543-56.
REF 23 Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol. 2003 Nov;17(11):2320-8.
REF 24 Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. Br J Cancer. 2001 Dec 14;85(12):1928-36.
REF 25 Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator. Endocrinology. 2000 Sep;141(9):3440-50.
REF 26 Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3. J Biol Chem. 2000 Feb 25;275(8):5976-82.
REF 27 Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres. Cytometry. 2001 Aug 1;44(4):326-37.
REF 28 Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Mol Cell Proteomics. 2009 Oct;8(10):2212-26.
REF 29 Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators. Mol Cell Biol. 2000 Nov;20(21):8008-17.
REF 30 Thyroid hormone receptor 1 domains responsible for the antagonism with the ras oncogene: role of corepressors. Oncogene. 2011 Feb 17;30(7):854-64.
REF 31 TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem. 1997 Oct 31;272(44):27629-34.
REF 32 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13.
REF 33 Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression. J Biol Chem. 2007 Jun 22;282(25):18584-96.
REF 34 Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. Mol Endocrinol. 1999 Dec;13(12):2151-62.
REF 35 Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter. Nucleic Acids Res. 2005 Apr 29;33(8):2440-51.
REF 36 Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain. Biochemistry. 2002 Feb 26;41(8):2500-8.
REF 37 The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007 Jan;27(1):120-34.
REF 38 Regulation of the BRCA1 gene by an SRC3/53BP1 complex. BMC Biochem. 2011 Sep 13;12:50.
REF 39 The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 1997 Jun 12;387(6634):677-84.
REF 40 Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin. Genes Dev. 2011 Jun 1;25(11):1132-46.
REF 41 Temporal/spatial expression of nuclear receptor coactivators in the mouse lung. Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1066-74.
REF 42 ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance. Mol Cell Biol. 2004 Jun;24(12):5157-71.
REF 43 Direct control of cell cycle gene expression by proto-oncogene product ACTR, and its autoregulation underlies its transforming activity. Mol Cell Biol. 2006 May;26(10):3810-23.
REF 44 P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain. Nucleic Acids Res. 2008 Apr;36(6):1847-60.
REF 45 Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene. 2011 Oct 20;30(42):4350-64.
REF 46 Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6997-7002.
REF 47 The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell. 2006 Jan 27;124(2):381-92.

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