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| Target General Information |
Top |
| Target ID |
T27418 |
Target Info
|
| Target Name |
Adenomatous polyposis coli 2 (APC2) |
| Synonyms |
Adenomatous polyposis coli proteinlike; Adenomatous polyposis coli protein-like; Adenomatous polyposis coli protein 2; APClike; APCL; APC-like |
| Target Type |
Literature-reported Target |
| Gene Name |
APC2 |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Other proteins |
[+] 1 Other proteins |
+ |
| Interacting Target Name |
Beta-catenin (CTNNB1) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| 3 |
Yeast two hybrid |
[3] |
| References |
Top |
| REF 1 |
Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation. PLoS One. 2013 Jul 1;8(7):e68072.
|
| REF 2 |
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev. 2006 Mar 1;20(5):601-12.
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| REF 3 |
The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol. 1999 Feb 25;9(4):207-10.
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