Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T28713 Target Info
Target Name Serine/threonine-protein kinase Chk2 (RAD53)
Synonyms hCds1; Hucds1; Checkpoint kinase 2; Cds1 homolog; Cds1; CHK2 checkpoint homolog; CHK2
Target Type Clinical trial Target
Gene Name CHEK2
Biochemical Class Kinase
UniProt ID
CHK2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Biochemical Activity [3]
4 Biochemical Activity [4]
5 Reconstituted Complex [1]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name M-phase inducer phosphatase 1 (MPIP1) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP1_HUMAN 
Synonyms Dual specificity phosphatase Cdc25A; Cdc25A phosphatase
Evidence Score (E-score) 5 Experimental Evidences +
1 Biochemical Activity [5]
2 Biochemical Activity [6]
3 Biochemical Activity [7]
4 Biochemical Activity [8]
5 Reconstituted Complex [8]
Kinases [+] 2 Kinases +
Interacting Target Name Polo-like kinase 1 (PLK1) Clinical trial Target Interacting Protein Info
UniProt ID
PLK1_HUMAN 
Synonyms STPK13; Serine-threonine protein kinase 13; Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; PLK-1; Plk1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [9]
Interacting Target Name ATM serine/threonine kinase (ATM) Clinical trial Target Interacting Protein Info
UniProt ID
ATM_HUMAN 
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [10]
2 Reconstituted Complex [10]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [12]
3 Biochemical Activity [13]
4 Biochemical Activity [14]
5 Biochemical Activity [15]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Biochemical Activity [17]
3 Biochemical Activity [13]
4 Reconstituted Complex [13]
Other proteins [+] 2 Other proteins +
Interacting Target Name Breast cancer type 2 susceptibility protein (BRCA2) Literature-reported Target Interacting Protein Info
UniProt ID
BRCA2_HUMAN 
Synonyms Fanconi anemia group D1 protein; FANCD1; FACD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Protein-peptide [19]
Interacting Protein Name Proteasome activator complex subunit 3 (PSME3) Interacting Protein Interacting Protein Info
UniProt ID
PSME3_HUMAN 
Synonyms HEL.S.283; Ki; PA28.gamma; PA28G; PA28gamma; REG.GAMMA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Biochemical Activity [21]
References  Top
REF 1 hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature. 2000 Mar 9;404(6774):201-4.
REF 2 BRCA1 is regulated by Chk2 in response to spindle damage. Biochim Biophys Acta. 2008 Dec;1783(12):2223-33.
REF 3 Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007 Apr 18;26(8):2083-93.
REF 4 Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer Res. 2002 Nov 15;62(22):6357-61.
REF 5 Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase. J Biol Chem. 2008 Jul 11;283(28):19322-8.
REF 6 Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell. 2003 Mar;3(3):247-58.
REF 7 Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. J Biol Chem. 2003 Aug 8;278(32):29824-9.
REF 8 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. 2001 Apr 12;410(6830):842-7.
REF 9 Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem. 2003 Mar 7;278(10):8468-75.
REF 10 Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science. 2004 Apr 2;304(5667):93-6.
REF 11 The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. J Biol Chem. 2003 Aug 29;278(35):33134-41.
REF 12 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 2000 Feb 1;14(3):289-300.
REF 13 HDM2 negatively affects the Chk2-mediated phosphorylation of p53. FEBS Lett. 2005 May 9;579(12):2604-8.
REF 14 DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science. 2000 Mar 10;287(5459):1824-7.
REF 15 ATM and Chk2 kinase target the p53 cofactor Strap. EMBO Rep. 2008 Dec;9(12):1222-9.
REF 16 Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities. Cell Cycle. 2009 Feb 1;8(3):430-7.
REF 17 Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol Cell Biol. 2006 Sep;26(18):6819-31.
REF 18 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6.
REF 19 Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies. Biochem Biophys Res Commun. 2003 Nov 28;311(4):803-8.
REF 20 REGgamma/PA28gamma proteasome activator interacts with PML and Chk2 and affects PML nuclear bodies number. Cell Cycle. 2009 Aug;8(15):2399-407.
REF 21 Chk2 and REG-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic Acids Res. 2014 Dec 1;42(21):13150-60.

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