Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T32262 Target Info
Target Name Calcitonin gene-related peptide receptor (CGRPR)
Synonyms Calcitonin receptor-like receptor; Calcitonin gene-related peptide type 1 receptor; CGRPR; CGRP type 1 receptor
Target Type Successful Target
Gene Name CALCRL
Biochemical Class GPCR secretin
UniProt ID
CALRL_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 1 Other proteins +
Interacting Protein Name Receptor activity-modifying protein 1 (RAMP1) Interacting Protein Interacting Protein Info
UniProt ID
RAMP1_HUMAN 
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Co-localization [4]
5 Reconstituted Complex [5]
6 Reconstituted Complex [4]
References  Top
REF 1 The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function. J Biol Chem. 2003 Apr 18;278(16):14313-20.
REF 2 Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin. J Biol Chem. 2001 Nov 9;276(45):42182-90.
REF 3 The transmembrane domain of receptor-activity-modifying protein 1 is essential for the functional expression of a calcitonin gene-related peptide receptor. Biochemistry. 2002 Sep 24;41(38):11398-404.
REF 4 RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9.
REF 5 Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins. Mol Pharmacol. 2004 Jan;65(1):207-13.

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