Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T33425 | Target Info | |||
| Target Name | Epidermal growth factor (EGF) | ||||
| Synonyms | Proepidermal growth factor; Pro-epidermal growth factor | ||||
| Target Type | Successful Target | ||||
| Gene Name | EGF | ||||
| Biochemical Class | Growth factor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III | ||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Affinity Capture-Luminescence | [1] | |||
| 2 | Affinity Capture-MS | [2] | |||
| 3 | Co-crystal Structure | [3] | |||
| 4 | Co-localization | [4] | |||
| 5 | Reconstituted Complex | [5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity. Hum Mol Genet. 2014 Dec 20;23(25):6779-96. | ||||
| REF 2 | Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics. 2009 Sep;8(9):2131-44. | ||||
| REF 3 | Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell. 2002 Sep 20;110(6):775-87. | ||||
| REF 4 | Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter. Int J Cancer. 2013 Feb 1;132(3):509-20. | ||||
| REF 5 | A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling. J Biol Chem. 1999 Mar 26;274(13):8900-9. | ||||
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