Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T38983 Target Info
Target Name Protein C-ets-1 (ETS1)
Synonyms P54; EWSR2
Target Type Literature-reported Target
Gene Name ETS1
Biochemical Class E26 transformation-specific ETS
UniProt ID
ETS1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [1]
2 Reconstituted Complex [2]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Protein-peptide [1]
3 Reconstituted Complex [1]
4 Reconstituted Complex [4]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Small integral membrane protein 40 (SMIM40) Interacting Protein Interacting Protein Info
UniProt ID
SIM40_HUMAN 
Synonyms BING2; DAP6; EAP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
3 Yeast two hybrid [6]
References  Top
REF 1 Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. Mol Cell Biol. 2004 Dec;24(24):10954-64.
REF 2 p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter. J Biol Chem. 1999 Jun 11;274(24):17342-52.
REF 3 A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol Cell Biol. 1998 Apr;18(4):2218-29.
REF 4 Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev. 1995 Apr 15;9(8):995-1008.
REF 5 Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx. J Biol Chem. 2006 Sep 22;281(38):28113-21.
REF 6 EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. Oncogene. 2000 Feb 10;19(6):745-53.

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