Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T44916 | Target Info | |||
Target Name | Embryonic ectoderm development protein (EED) | ||||
Synonyms | hEED; WD protein associating with integrin cytoplasmic tails 1; WAIT-1 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | EED | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Carbon-nitrogen hydrolases | [+] 1 Carbon-nitrogen hydrolases | + | |||
Interacting Target Name | Histone deacetylase 1 (HDAC1) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RPD3L1; HD1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
One-carbon transferases | [+] 2 One-carbon transferases | + | |||
Interacting Target Name | Enhancer of zeste homolog 2 (EZH2) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Lysine N-methyltransferase 6; Lysine Nmethyltransferase 6; KMT6; Histone-lysine N-methyltransferase EZH2; Histonelysine Nmethyltransferase EZH2; EZH2 Y641N mutations; EZH2 Y641F mutations; ENX-1; ENX1 | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [3] | |||
3 | Biochemical Activity | [4] | |||
4 | Co-localization | [5] | |||
5 | Reconstituted Complex | [4] | |||
6 | Yeast two hybrid | [6] | |||
Interacting Target Name | Enhancer of zeste homolog 1 (EZH1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | KIAA0388; Histone-lysine N-methyltransferase EZH1; ENX-2 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [7] | |||
2 | Affinity Capture-Western | [8] | |||
3 | Reconstituted Complex | [9] | |||
4 | Yeast two hybrid | [6] |
References | Top | ||||
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REF 1 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23. | ||||
REF 2 | Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet. 1999 Dec;23(4):474-8. | ||||
REF 3 | JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature. 2010 Mar 11;464(7286):306-10. | ||||
REF 4 | Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev. 2010 Dec 1;24(23):2615-20. | ||||
REF 5 | The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127. | ||||
REF 6 | Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol. 1998 Jun;18(6):3572-9. | ||||
REF 7 | A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. | ||||
REF 8 | Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 2008 Nov 21;32(4):503-18. | ||||
REF 9 | The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression. Mol Cell Biol. 1998 May;18(5):2825-34. |
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