Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T46084 Target Info
Target Name TNF related apoptosis inducing ligand (TNFSF10)
Synonyms Tumor necrosis factor ligand superfamily member 10; TRAIL; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD253; Apo-2L; Apo-2 ligand; APO2L
Target Type Clinical trial Target
Gene Name TNFSF10
Biochemical Class Cytokine: tumor necrosis factor
UniProt ID
TNF10_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 1 Other proteins +
Interacting Target Name TRAIL receptor 2 (TRAIL-R2) Clinical trial Target Interacting Protein Info
UniProt ID
TR10B_HUMAN 
Synonyms ZTNFR9; UNQ160/PRO186; Tumor necrosis factor receptor superfamily member 10B; TRICK2; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; KILLER; DR5; Death receptor 5; CD262
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-crystal Structure [5]
6 Reconstituted Complex [6]
7 Reconstituted Complex [5]
References  Top
REF 1 TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 1997 Sep 1;16(17):5386-97.
REF 2 Identification of a novel pro-apoptotic role of NF-B in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. Oncogene. 2012 Mar 15;31(11):1468-74.
REF 3 A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma. Cancer Discov. 2012 Feb;2(2):140-55.
REF 4 The role of Cullin3-mediated ubiquitination of the catalytic subunit of PP2A in TRAIL signaling. Cell Cycle. 2014;13(23):3750-8.
REF 5 Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol Cell. 1999 Oct;4(4):563-71.
REF 6 Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). FEBS Lett. 2000 Nov 24;485(2-3):135-41.

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