Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T49989 Target Info
Target Name TGF-beta receptor type II (TGFBR2)
Synonyms Transforminggrowth factor-beta receptor type II; Transforming growth factor-beta receptor type II; TbetaR-II; TGFR-2; TGF-beta type II receptor; TGF-beta receptor type-2
Target Type Clinical trial Target
Gene Name TGFBR2
Biochemical Class Kinase
UniProt ID
TGFR2_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Neuropilin-1 (NRP1) Successful Target Interacting Protein Info
UniProt ID
NRP1_HUMAN 
Synonyms VEGF165R; Vascular endothelial cell growth factor 165 receptor; Platelet-derived endothelial cell growth factor receptor; NRP; Membrane-bound; CD304
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Growth factors [+] 2 Growth factors +
Interacting Target Name Transforming growth factor beta 1 (TGFB1) Successful Target Interacting Protein Info
UniProt ID
TGFB1_HUMAN 
Synonyms Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1; TGF-beta1; TGF-beta 1; TGFB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [5]
Interacting Target Name Transforming growth factor beta 3 (TGFB3) Clinical trial Target Interacting Protein Info
UniProt ID
TGFB3_HUMAN 
Synonyms Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3; TGF-beta-3; Latency-associated peptide
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [3]
3 Co-crystal Structure [7]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [8]
Kinases [+] 3 Kinases +
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [11]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) Interacting Protein Interacting Protein Info
UniProt ID
P85B_HUMAN 
Synonyms MPPH; MPPH1; P85B; p85; p85.BETA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [11]
Interacting Target Name TGF-beta receptor type I (TGFBR1) Clinical trial Target Interacting Protein Info
UniProt ID
TGFR1_HUMAN 
Synonyms Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; TbetaR-I; TbetaRI; SKR4; Serine/threonine-protein kinase receptor R4; ALK-5; ALK5; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Yeast two hybrid [13]
Other proteins [+] 1 Other proteins +
Interacting Target Name Endoglin CD105 (ENG) Clinical trial Target Interacting Protein Info
UniProt ID
EGLN_HUMAN 
Synonyms END; CD105 antigen; CD105
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Affinity Capture-Western [6]
3 Biochemical Activity [14]
References  Top
REF 1 Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype. J Biol Chem. 2010 Oct 8;285(41):31840-8.
REF 2 Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta. Carcinogenesis. 2011 Apr;32(4):613-21.
REF 3 Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. EMBO J. 2001 Feb 1;20(3):480-90.
REF 4 Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell. 1993 Nov 19;75(4):671-80.
REF 5 A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic ... J Biol Chem. 1993 Jun 15;268(17):12719-23.
REF 6 Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem. 1999 Jan 8;274(2):584-94.
REF 7 Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex. Nat Struct Biol. 2002 Mar;9(3):203-8.
REF 8 Critical regulation of TGFbeta signaling by Hsp90. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9244-9.
REF 9 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 10 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 11 TGF-beta 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells. Am J Physiol. 1997 Dec;273(6 Pt 1):L1220-7.
REF 12 Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. J Biol Chem. 2009 Aug 14;284(33):22285-96.
REF 13 TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol. 2001 Aug;3(8):708-14.
REF 14 Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. J Biol Chem. 2002 Aug 9;277(32):29197-209.

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