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| Target General Information |
Top |
| Target ID |
T50914 |
Target Info
|
| Target Name |
Protein phosphatase 1D (PPM1D) |
| Synonyms |
p53-induced protein phosphatase 1; WIP1; Protein phosphatase magnesium-dependent 1 delta; Protein phosphatase 2C isoform delta; PP2C-delta |
| Target Type |
Literature-reported Target |
| Gene Name |
PPM1D |
| Biochemical Class |
Phosphoric monoester hydrolase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Histones |
[+] 1 Histones |
+ |
| Interacting Target Name |
Gamma-Histone H2AX (H2AFX) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2AX; H2a/x |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Biochemical Activity |
[2] |
| 3 |
Biochemical Activity |
[1] |
| 4 |
Biochemical Activity |
[3] |
| References |
Top |
| REF 1 |
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair. J Biol Chem. 2010 Apr 23;285(17):12935-47.
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| REF 2 |
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition. Oncogene. 2010 Apr 15;29(15):2281-91.
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| REF 3 |
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res. 2010 May 15;70(10):4112-22.
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