Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T51734 Target Info
Target Name CCAAT/enhancer binding protein beta (CEBPB)
Synonyms Transcription factor CCAAT/enhancer-binding protein beta; Transcription factor 5; TCF5; TCF-5; PP9092; Nuclear factor NF-IL6; Liver-enriched inhibitory protein; Liver activator protein; LIP; LAP; CCAAT/enhancer-binding protein beta; C/EBP beta
Target Type Literature-reported Target
Gene Name CEBPB
Biochemical Class Basic leucine zipper bZIP
UniProt ID
CEBPB_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Probable global transcription activator SNF2L2 (SMARCA2) Interacting Protein Interacting Protein Info
UniProt ID
SMCA2_HUMAN 
Synonyms BAF190; BRM; NCBRS; SNF2; SNF2L2; SNF2LA; SWI2; Sth1p; hBRM; hSNF2a
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [3]
3 Yeast two hybrid [2]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Far Western [4]
3 Reconstituted Complex [5]
Nuclear hormone receptors [+] 2 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-localization [7]
3 Reconstituted Complex [8]
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Early growth response protein 1 (EGR-1) Clinical trial Target Interacting Protein Info
UniProt ID
EGR1_HUMAN 
Synonyms ZNF225; Zinc finger protein Krox-24; Zinc finger protein Krox24; Zinc finger protein 225; Transcription factor Zif268; Transcription factor ETR103; NGFI-A; NGFIA; Nerve growth factor-induced protein A; Nerve growth factorinduced protein A; KROX24; AT225
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [12]
3 Yeast two hybrid [12]
References  Top
REF 1 A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. Mol Cell. 1999 Nov;4(5):735-43.
REF 2 Interaction and functional collaboration of p300 and C/EBPbeta. Mol Cell Biol. 1997 Nov;17(11):6609-17.
REF 3 Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators. Blood. 2004 Mar 15;103(6):2135-42.
REF 4 Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):465-9.
REF 5 Retinoblastoma protein complexes with C/EBP proteins and activates C/EBP-mediated transcription. J Cell Biochem. 2001 Aug 21-Sep 5;83(3):414-25.
REF 6 A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor. J Biol Chem. 2006 Jul 7;281(27):18825-36.
REF 7 Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2. J Biol Chem. 2009 Oct 16;284(42):28607-15.
REF 8 AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor. Mol Endocrinol. 1998 Nov;12(11):1749-63.
REF 9 Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP. Blood. 2007 Dec 15;110(13):4373-84.
REF 10 The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-gamma (PPARgamma) and thiazolidinedione-PPARgamma agonists. Endocr Relat Cancer. 2008 Mar;15(1):325-35.
REF 11 Regulation of human microsomal prostaglandin E synthase-1 by IL-1 requires a distal enhancer element with a unique role for C/EBP. Biochem J. 2012 Apr 15;443(2):561-71.
REF 12 Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene. J Biol Chem. 2003 Nov 7;278(45):44246-54.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.