Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T52189 Target Info
Target Name ATP-citrate synthase (ACLY)
Synonyms Citrate cleavage enzyme; ATP-citrate (pro-S-)-lyase; ACL
Target Type Successful Target
Gene Name ACLY
Biochemical Class Acyltransferase
UniProt ID
ACLY_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase UBR4 (UBR4) Interacting Protein Interacting Protein Info
UniProt ID
UBR4_HUMAN 
Synonyms RBAF600; ZUBR1; p600
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Cullins [+] 1 Cullins +
Interacting Target Name Cullin-3 (CUL-3) Literature-reported Target Interacting Protein Info
UniProt ID
CUL3_HUMAN 
Synonyms KIAA0617; Cullin3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [1]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [5]
References  Top
REF 1 Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016 Sep 1;30(17):1956-70.
REF 2 Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013 Aug 22;51(4):506-518.
REF 3 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
REF 4 Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain. J Biol Chem. 2007 Aug 10;282(32):23184-93.
REF 5 Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes EMBO J. 2013 Feb 20;32(4):552-65.

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